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Biology and Biochemistry

D-Index
55
Citations
8885
World Ranking
15245
National Ranking
6369

Overview

William F. Goins is affiliated with the University of Pittsburgh in the United States. Their research focuses primarily on the intersection of biochemistry, genetics, molecular biology, and medicine. They have contributed extensively to the fields of genetics, molecular biology, epidemiology, oncology, and biotechnology.

Their work covers several main topics, including:

  • Virus-based gene therapy research
  • Herpesvirus infections and treatments
  • Viral infectious diseases and gene expression in insects
  • CAR-T cell therapy research
  • Cancer research and treatments
  • Healthcare and venom research
  • Pain mechanisms and treatments

William F. Goins has published numerous papers across a range of specialized journals, often contributing to research on virotherapy and cancer biology. Their recent publications include:

  • "Agent-based computational modeling of glioblastoma predicts that stromal density is central to oncolytic virus efficacy," 2022, published in iScience
  • "Glioblastoma infiltration of both tumor- and virus-antigen specific cytotoxic T cells correlates with experimental virotherapy responses," 2020, published in Scientific Reports
  • "Oncolytic HSV Vectors and Anti-Tumor Immunity," 2020, published in Current Issues in Molecular Biology
  • "A Guide to Preclinical Models of Zoster-Associated Pain and Postherpetic Neuralgia," 2021, published in Current Topics in Microbiology and Immunology
  • "Generation of an Oncolytic Herpes Simplex Viral Vector Completely Retargeted to the GDNF Receptor GFRα1 for Specific Infection of Breast Cancer Cells," 2020, published in International Journal of Molecular Sciences

Their contributions have appeared frequently in the following publication venues:

  • Neuro-Oncology
  • Molecular Therapy - Methods & Clinical Development
  • Cancer Research
  • Molecular Therapy Oncology
  • Molecular Therapy

William F. Goins has collaborated extensively with other researchers, including:

  • E. Antonio Chiocca
  • Joseph C. Glorioso
  • Hiroshi Nakashima
  • Justus B. Cohen
  • Bonnie L. Hall

Best Publications

  • A new transgene reporter for in vivo magnetic resonance imaging.

    Guillem Genove;Ulrike DeMarco;Hongyan Xu;William F Goins

  • Promoter-regulatory region of the major immediate early gene of human cytomegalovirus

    Darrell R. Thomsen;Richard M. Stenberg;William F. Goins;Mark F. Stinski

  • Deletion of multiple immediate-early genes from herpes simplex virus reduces cytotoxicity and permits long-term gene expression in neurons.

    D. M. Krisky;D. Wolfe;W. F. Goins;P. C. Marconi

  • Antihyperalgesic effects of infection with a preproenkephalin-encoding herpes virus

    Steven P. Wilson;David C. Yeomans;Mary Ann Bender;Ying Lu

  • Progress in gene therapy for neurological disorders

    Michele Simonato;Jean Bennett;Nicholas M. Boulis;Maria G. Castro

  • Gene transfer to neurons using herpes simplex virus-based vectors.

    D J Fink;N A DeLuca;W F Goins;J C Glorioso

  • In vivo expression of β-galactosidase in hippocampal neurons by HSV-mediated gene transfer

    David J. Fink;Lawrence R. Sternberg;Lawrence R. Sternberg;Peter C. Weber;Peter C. Weber;Marina Mata

  • Replication-defective herpes simplex virus vectors for gene transfer in vivo.

    Peggy Marconi;David Krisky;Thomas Oligino;Pietro L. Poliani

  • A novel latency-active promoter is contained within the herpes simplex virus type 1 UL flanking repeats.

    W F Goins;L R Sternberg;K D Croen;P R Krause

  • Antinociceptive effect of a genomic herpes simplex virus-based vector expressing human proenkephalin in rat dorsal root ganglion.

    J R Goss;M Mata;M Mata;W F Goins;H H Wu

  • Transgene-mediated enkephalin release enhances the effect of morphine and evades tolerance to produce a sustained antiallodynic effect in neuropathic pain.

    Shuanglin Hao;Marina Mata;William Goins;Joseph C. Glorioso

  • Herpes Simplex-Mediated Gene Transfer of Nerve Growth Factor Protects Against Peripheral Neuropathy in Streptozotocin-Induced Diabetes in the Mouse

    James R. Goss;William F. Goins;David Lacomis;Marina Mata

  • Herpes vector-mediated expression of proenkephalin reduces bone cancer pain.

    James R. Goss;Cara F. Harley;Marina Mata;Marina Mata;Mark E. O'Malley

  • Two herpes simplex virus type 1 latency-active promoters differ in their contributions to latency-associated transcript expression during lytic and latent infections.

    X Chen;M C Schmidt;W F Goins;J C Glorioso

  • Herpes simplex virus RNAi and neprilysin gene transfer vectors reduce accumulation of Alzheimer's disease-related amyloid-β peptide in vivo

    C.-S. Hong;W. F. Goins;J. R. Goss;E. A. Burton

  • HERPES SIMPLEX VIRUS MEDIATED NERVE GROWTH FACTOR EXPRESSION IN BLADDER AND AFFERENT NEURONS: POTENTIAL TREATMENT FOR DIABETIC BLADDER DYSFUNCTION

    William F. Goins;Naoki Yoshimura;Michael W. Phelan;Teruhiko Yokoyama

  • HSV trafficking and development of gene therapy vectors with applications in the nervous system.

    A. R. Frampton;W. F. Goins;kenji nakano;E. A. Burton

  • Gene therapy using replication-defective herpes simplex virus vectors expressing nerve growth factor in a rat model of diabetic cystopathy.

    Katsumi Sasaki;Michael B. Chancellor;William F. Goins;Michael W. Phelan

  • Herpes Simplex Virus Type 1 Vector-Mediated Expression of Nerve Growth Factor Protects Dorsal Root Ganglion Neurons from Peroxide Toxicity

    William F. Goins;Kevin A. Lee;James D. Cavalcoli;Mark E. O’Malley

  • Connexin 43-Enhanced Suicide Gene Therapy Using Herpesviral Vectors

    Peggy Marconi;Masakazu Tamura;Shusuke Moriuchi;David M. Krisky

Frequent Co-Authors

Joseph C. Glorioso
Joseph C. Glorioso University of Pittsburgh
Naoki Yoshimura
Naoki Yoshimura University of Pittsburgh
Michael B. Chancellor
Michael B. Chancellor University of Pittsburgh
William C. de Groat
William C. de Groat University of Pittsburgh
Balveen Kaur
Balveen Kaur Augusta University
E. Antonio Chiocca
E. Antonio Chiocca Brigham and Women's Hospital
Paul R. Kinchington
Paul R. Kinchington University of Pittsburgh
David Fink
David Fink Australian Nuclear Science and Technology Organisation
Michele Simonato
Michele Simonato University of Ferrara
Neal A. DeLuca
Neal A. DeLuca University of Pittsburgh

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