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Microbiology

D-Index
54
Citations
8640
World Ranking
4013
National Ranking
1559

Overview

Paul R. Kinchington is affiliated with the University of Pittsburgh in the United States. Their research expertise lies predominantly in the field of Medicine, with a specialized focus on Epidemiology, Immunology, Physiology, Pharmacology, and Molecular Biology. Kinchington's work spans multiple topics related to viral infections and immune responses.

The scientist has contributed extensively to the following research topics:

  • Herpesvirus Infections and Treatments
  • Cytomegalovirus and herpesvirus research
  • Healthcare and Venom Research
  • Pain Mechanisms and Treatments
  • Virus-based gene therapy research
  • Interferon and immune responses
  • RNA regulation and disease

Kinchington has published papers in several well-regarded scientific journals, frequently contributing to:

  • Journal of Virology
  • Viruses
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Current topics in microbiology and immunology
  • Autophagy

Some of the recent papers authored or co-authored by Kinchington include:

  • BNIP3L-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes, 2021, Autophagy
  • Virus-Mediated Suppression of the Antigen Presentation Molecule MR1, 2020, Cell Reports
  • Production of the Cytokine VEGF-A by CD4+ T and Myeloid Cells Disrupts the Corneal Nerve Landscape and Promotes Herpes Stromal Keratitis, 2020, Immunity
  • Varicella-Zoster virus ORF9 is an antagonist of the DNA sensor cGAS, 2022, The EMBO Journal
  • Stem cell transplantation rescued a primary open-angle glaucoma mouse model, 2021, eLife

Among frequent collaborators, Kinchington has worked significantly with:

  • Phillip R. Kramer
  • Leonardo D'Aiuto
  • Vishwajit L. Nimgaonkar
  • David C. Bloom
  • Rebecca Hornung

Their research contributions emphasize the intersections of viral pathogenesis, immune system dynamics, and therapeutic interventions related to herpesvirus infections. The diversity in the scientist's coauthorship and publication venues reflects active engagement with multidisciplinary approaches within biomedical research.

Best Publications

  • Herpes Simplex Virus-Specific Memory CD8+ T Cells Are Selectively Activated and Retained in Latently Infected Sensory Ganglia

    Kamal M. Khanna;Robert H. Bonneau;Paul R. Kinchington;Robert L. Hendricks

  • Noncytotoxic lytic granule-mediated CD8+ T cell inhibition of HSV-1 reactivation from neuronal latency.

    Jared E. Knickelbein;Kamal M. Khanna;Michael B. Yee;Catherine J. Baty

  • Attenuation of the Vaccine Oka Strain of Varicella-Zoster Virus and Role of Glycoprotein C in Alphaherpesvirus Virulence Demonstrated in the SCID-hu Mouse

    Jennifer F. Moffat;Leigh Zerboni;Paul R. Kinchington;Charles Grose

  • Selective retention of herpes simplex virus-specific T cells in latently infected human trigeminal ganglia.

    Georges M. G. M. Verjans;Rogier Q. Hintzen;Jessica M. van Dun;Angelique Poot

  • The varicella-zoster virus immediate-early protein IE62 is a major component of virus particles.

    P R Kinchington;J K Hougland;A M Arvin;W T Ruyechan

  • Further characterization of a rat model of varicella zoster virus-associated pain: Relationship between mechanical hypersensitivity and anxiety-related behavior, and the influence of analgesic drugs.

    F.S. Hasnie;J. Breuer;S. Parker;V. Wallace

  • Equivalent recognition of a varicella-zoster virus immediate early protein (IE62) and glycoprotein I by cytotoxic T lymphocytes of either CD4+ or CD8+ phenotype.

    A M Arvin;M Sharp;S Smith;C M Koropchak

  • Gamma Interferon Can Block Herpes Simplex Virus Type 1 Reactivation from Latency, Even in the Presence of Late Gene Expression

    Vilma Decman;Paul R. Kinchington;Stephen A. K. Harvey;Robert L. Hendricks

  • Varicella zoster virus induces neuropathic changes in rat dorsal root ganglia and behavioral reflex sensitisation that is attenuated by gabapentin or sodium channel blocking drugs.

    Emer M Garry;Ada Delaney;Heather A Anderson;Eva C Sirinathsinghji

  • Varicella-Zoster Virus Gene 66 Transcription and Translation in Latently Infected Human Ganglia

    Randall J. Cohrs;Donald H. Gilden;Paul R. Kinchington;Esther Grinfeld

  • Involvement of IL-6 in the paracrine production of VEGF in ocular HSV-1 infection.

    Partha Sarathi Biswas;Kaustuv Banerjee;Paul R. Kinchington;Barry T. Rouse

  • The transcriptional regulatory proteins encoded by varicella-zoster virus open reading frames (ORFs) 4 and 63, but not ORF 61, are associated with purified virus particles.

    P R Kinchington;D Bookey;S E Turse

  • Downregulation of Class I Major Histocompatibility Complex Surface Expression by Varicella-Zoster Virus Involves Open Reading Frame 66 Protein Kinase-Dependent and -Independent Mechanisms

    Amie J. Eisfeld;Michael B. Yee;Angela Erazo;Allison Abendroth;Allison Abendroth

  • Phosphorylation of varicella-zoster virus open reading frame (ORF) 62 regulatory product by viral ORF 47-associated protein kinase.

    T I Ng;L Keenan;P R Kinchington;C Grose

  • Large-scale generation of human iPSC-derived neural stem cells/early neural progenitor cells and their neuronal differentiation

    Leonardo D’Aiuto;Yun Zhi;Yun Zhi;Dhanjit Kumar Das;Dhanjit Kumar Das;Madeleine R. Wilcox

  • A5-Positive Primary Sensory Neurons Are Nonpermissive for Productive Infection with Herpes Simplex Virus 1 In Vitro

    Andrea S. Bertke;Sophia M. Swanson;Jenny Chen;Yumi Imai

  • Herpes simplex virus and varicella zoster virus, the house guests who never leave

    Paul R Kinchington;Anthony J St Leger;Jean-Marc G Guedon;Robert L Hendricks

  • Human trophoblasts confer resistance to viruses implicated in perinatal infection

    Avraham Bayer;Elizabeth Delorme-Axford;Christie Sleigher;Teryl K. Frey

  • Nuclear Accumulation of IE62, the Varicella-Zoster Virus (VZV) Major Transcriptional Regulatory Protein, Is Inhibited by Phosphorylation Mediated by the VZV Open Reading Frame 66 Protein Kinase

    Paul R. Kinchington;Karen Fite;Stephanie E. Turse

  • Deep Sequencing of Viral Genomes Provides Insight into the Evolution and Pathogenesis of Varicella Zoster Virus and Its Vaccine in Humans

    Daniel P. Depledge;Samit Kundu;Nancy J. Jensen;Eleanor R. Gray

  • Immune control of HSV-1 latency.

    Vilma Decman;Michael L Freeman;Paul R Kinchington;Robert L Hendricks

  • Prospects for adenovirus antivirals

    Paul R. Kinchington;Eric G. Romanowski;Y. Jerold Gordon

Frequent Co-Authors

Robert L. Hendricks
Robert L. Hendricks University of Pittsburgh
Vishwajit L. Nimgaonkar
Vishwajit L. Nimgaonkar University of Pittsburgh
William F. Goins
William F. Goins University of Pittsburgh
Ann M. Arvin
Ann M. Arvin Stanford University
Robert H. Yolken
Robert H. Yolken Johns Hopkins University
Larry L. Bellinger
Larry L. Bellinger Texas A&M University
Barry Slobedman
Barry Slobedman University of Sydney
James McNulty
James McNulty McMaster University
Jamie Rossjohn
Jamie Rossjohn Monash University
Joseph C. Glorioso
Joseph C. Glorioso University of Pittsburgh

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