World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
10883
World Ranking
13914
National Ranking
5880

Overview

John H. Wolfe is affiliated with the University of Pennsylvania in the United States. Their research spans several interconnected fields including Biochemistry, Genetics and Molecular Biology, Medicine, and Neuroscience. Within these broader areas, they have contributed extensively to Molecular Biology, Genetics, Cellular and Molecular Neuroscience, Epidemiology, and Physiology.

The scientist's work focuses on several main topics, notably virus-based gene therapy research, retinal development and disorders, herpesvirus infections and treatments, and lysosomal storage disorders research. Additional research interests include neuroscience and neural engineering, photoreceptor and optogenetics research, and cytomegalovirus and herpesvirus research.

Recent publications from John H. Wolfe illustrate a focus on gene therapy and neural research. These include:

  • Intracisternal vs intraventricular injection of AAV1 result in comparable, widespread transduction of the dog brain (2024, Gene Therapy)
  • Systemic immunosuppression promotes survival and integration of subretinally implanted human ESC-derived photoreceptor precursors in dogs (2022, Stem Cell Reports)
  • Transduction characteristics of alternative adeno-associated virus serotypes in the cat brain by intracisternal delivery (2022, Molecular Therapy - Methods & Clinical Development)
  • Islet1 Precursors Contribute to Mature Interneuron Subtypes in Mouse Neocortex (2021, Cerebral Cortex)
  • Global CNS correction in a large brain model of human alpha-mannosidosis by intravascular gene therapy (2020, Brain)

John H. Wolfe frequently publishes in several scientific venues, among which Molecular Therapy - Methods & Clinical Development features prominently with three publications. Other venues include Stem Cell Reports, Brain, Cerebral Cortex, and Gene Therapy.

Collaboration is a significant aspect of their research approach. Frequent coauthors include Jacqueline E. Hunter, Caitlyn Molony, Charles H. Vite, Sanjeev Chawla, and Patricia A. O'Donnell, with the highest coauthor count being five shared papers each with Jacqueline E. Hunter and Caitlyn Molony.

Best Publications

  • Engraftable human neural stem cells respond to development cues, replaceneurons, and express foreign genes

    Jonathan D. Flax;Sanjay Aurora;Chunhua Yang;Clemence Simonin

  • Neural progenitor cell engraftment corrects lysosomal storage throughout the MPS VII mouse brain.

    Evan Y. Snyder;Rosanne M. Taylor;Rosanne M. Taylor;John H. Wolfe

  • Transduction characteristics of adeno-associated virus vectors expressing cap serotypes 7, 8, 9, and Rh10 in the mouse brain.

    Cassia N. Cearley;John H. Wolfe

  • Intraventricular Brain Injection of Adeno-Associated Virus Type 1 (AAV1) in Neonatal Mice Results in Complementary Patterns of Neuronal Transduction to AAV2 and Total Long-Term Correction of Storage Lesions in the Brains of β-Glucuronidase-Deficient Mice

    Marco A. Passini;Deborah J. Watson;Charles H. Vite;Daniel J. Landsburg

  • Targeted Transduction Patterns in the Mouse Brain by Lentivirus Vectors Pseudotyped with VSV, Ebola, Mokola, LCMV, or MuLV Envelope Proteins

    Deborah J. Watson;Deborah J. Watson;Gary P. Kobinger;Marco A. Passini;Marco A. Passini;James M. Wilson

  • A single injection of an adeno-associated virus vector into nuclei with divergent connections results in widespread vector distribution in the brain and global correction of a neurogenetic disease.

    Cassia N Cearley;John H Wolfe

  • Progress in gene therapy for neurological disorders

    Michele Simonato;Jean Bennett;Nicholas M. Boulis;Maria G. Castro

  • Dosage Thresholds for AAV2 and AAV8 Photoreceptor Gene Therapy in Monkey

    Luk H. Vandenberghe;Peter Bell;Albert M. Maguire;Albert M. Maguire;Cassia N. Cearley;Cassia N. Cearley

  • Reversal of pathology in murine mucopolysaccharidosis type VII by somatic cell gene transfer.

    John H. Wolfe;Mark S. Sands;Jane E. Barker;Babette Gwynn

  • Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration.

    Danielle Emille Mor;Elpida Tsika;Joseph R Mazzulli;Neal S Gould

  • Herpesvirus vector gene transfer and expression of β–glucuronidase in the central nervous system of MRS VII mice

    John H. Wolfe;Satish L. Deshmane;Nigel W. Fraser

  • Widespread Gene Delivery and Structure-Specific Patterns of Expression in the Brain after Intraventricular Injections of Neonatal Mice with an Adeno-Associated Virus Vector

    Marco A. Passini;John H. Wolfe

  • Therapeutic neonatal hepatic gene therapy in mucopolysaccharidosis VII dogs

    Katherine Parker Ponder;John R Melniczek;Lingfei Xu;Margaret A Weil

  • Sustained Production of β-Glucuronidase from Localized Sites after AAV Vector Gene Transfer Results in Widespread Distribution of Enzyme and Reversal of Lysosomal Storage Lesions in a Large Volume of Brain in Mucopolysaccharidosis VII Mice

    Annette F. Skorupa;Krisna J. Fisher;James M. Wilson;Michael K. Parente

  • Expanded repertoire of AAV vector serotypes mediate unique patterns of transduction in mouse brain.

    Cassia N Cearley;Luk H Vandenberghe;Michael K Parente;Michael K Parente;Erin R Carnish;Erin R Carnish

  • Decreased lysosomal storage in the adult MPS VII mouse brain in the vicinity of grafts of retroviral vector-corrected fibroblasts secreting high levels of beta-glucuronidase.

    Rosanne M Taylor;John H Wolfe

  • Enhancing GABA(A) receptor alpha 1 subunit levels in hippocampal dentate gyrus inhibits epilepsy development in an animal model of temporal lobe epilepsy.

    YogendraSinh H Raol;Ingrid V Lund;Sabita Bandyopadhyay;Guojun Zhang

  • Adeno-associated virus serotypes 1, 8, and 9 share conserved mechanisms for anterograde and retrograde axonal transport.

    Michael J. Castle;Zachary T. Gershenson;April R. Giles;Erika L.F. Holzbaur

  • Distribution of a Lysosomal Enzyme in the Adult Brain by Axonal Transport and by Cells of the Rostral Migratory Stream

    Marco A. Passini;Edward B. Lee;Gregory G. Heuer;John H. Wolfe

  • Controlling AAV Tropism in the Nervous System with Natural and Engineered Capsids

    Michael J. Castle;Michael J. Castle;Heikki T. Turunen;Luk H. Vandenberghe;John H. Wolfe;John H. Wolfe

Frequent Co-Authors

Nigel W. Fraser
Nigel W. Fraser University of Pennsylvania
Luk H. Vandenberghe
Luk H. Vandenberghe Massachusetts Eye and Ear Infirmary
Gustavo D. Aguirre
Gustavo D. Aguirre University of Pennsylvania
James M. Wilson
James M. Wilson University of Pennsylvania
L. A. Frank
L. A. Frank University of Iowa
Rita J. Valentino
Rita J. Valentino National Institute on Drug Abuse
Jean Bennett
Jean Bennett University of Pennsylvania
John Q. Trojanowski
John Q. Trojanowski University of Pennsylvania
Virginia M.-Y. Lee
Virginia M.-Y. Lee University of Pennsylvania
Joseph C. Glorioso
Joseph C. Glorioso University of Pittsburgh

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Studying Biology and Biochemistry opens doors to a variety of healthcare and science careers. Today, numerous accelerated bachelor's degree in biology online programs make it quicker and easier for students to earn a degree without pausing their current commitments. These fast-track courses are ideal for those eager to enter the workforce or advance to graduate study.

Many students also consider healthcare roles that offer stable demand and rewarding work. Exploring specialized pathways such as cma to lpn transition programs helps certified medical assistants quickly upskill to become Licensed Practical Nurses, streamlining clinical career progression.

Nursing remains one of the most popular fields for biology and biochemistry graduates. With options like online asn programs, students can earn foundational qualifications to begin nursing careers in just two years–often with flexible study options for working adults.

For those passionate about health, diet, and wellness, an online bachelor's in nutrition can lead to careers in clinical nutrition, public health, and research. Whichever path you choose, online programs provide accessible opportunities for career advancement in biology, biochemistry, and related fields.

Best Scientists Citing John H. Wolfe

Trending Scientists

Recently Published Articles