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Biology and Biochemistry

D-Index
69
Citations
12521
World Ranking
7583
National Ranking
3446

Overview

Mark S. Sands is affiliated with Washington University in St. Louis in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a particular focus on subfields such as Physiology, Molecular Biology, Cell Biology, Epidemiology, and Surgery.

The main topics of Mark S. Sands's research include:

  • Lysosomal Storage Disorders Research
  • Cellular transport and secretion
  • Trypanosoma species research and implications
  • RNA regulation and disease
  • Glycogen Storage Diseases and Myoclonus
  • Adenosine and Purinergic Signaling
  • Carbohydrate Chemistry and Synthesis

Mark S. Sands has published numerous papers in several scientific venues. Frequent publication venues include:

  • Molecular Genetics and Metabolism
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Clinical Investigation
  • Molecular Therapy
  • Scientific Reports

Recent papers authored or co-authored by Mark S. Sands cover a range of topics, especially related to Krabbe disease and gene therapy. Notable publications include:

  • "Krabbe disease: New hope for an old disease," 2021, Neuroscience Letters
  • "Krabbe disease successfully treated via monotherapy of intrathecal gene therapy," 2020, Journal of Clinical Investigation
  • "Macrophage secretion of miR-106b-5p causes renin-dependent hypertension," 2020, Nature Communications
  • "Enhanced Efficacy and Increased Long-Term Toxicity of CNS-Directed, AAV-Based Combination Therapy for Krabbe Disease," 2020, Molecular Therapy
  • "Waning efficacy in a long-term AAV-mediated gene therapy study in the murine model of Krabbe disease," 2021, Molecular Therapy

Their frequent collaborators include:

  • Jonathan D. Cooper
  • Hemanth R. Nelvagal
  • Elizabeth M. Eultgen
  • Joshua T. Dearborn
  • Keigo Takahashi

Over the course of their career, Mark S. Sands has contributed extensively to the understanding of lysosomal storage disorders, particularly in relation to gene therapy approaches. This work is situated within a broader context of molecular genetics and metabolic research that informs the diagnosis and treatment of inherited metabolic diseases.

Best Publications

  • AAV Vector Integration Sites in Mouse Hepatocellular Carcinoma

    Anthony Donsante;Daniel G. Miller;Yi Li;Carole Vogler

  • Gene therapy for lysosomal storage diseases.

    Mark S. Sands;Beverly L. Davidson

  • CMV-β-Actin Promoter Directs Higher Expression from an Adeno-Associated Viral Vector in the Liver than the Cytomegalovirus or Elongation Factor 1α Promoter and Results in Therapeutic Levels of Human Factor X in Mice

    Lingfei Xu;Thomas Daly;Cuihua Gao;Terence R. Flotte

  • Background mutations in parental cells account for most of the genetic heterogeneity of induced pluripotent stem cells.

    Margaret A. Young;David E. Larson;Chiao Wang Sun;Daniel R. George

  • Reversal of pathology in murine mucopolysaccharidosis type VII by somatic cell gene transfer.

    John H. Wolfe;Mark S. Sands;Jane E. Barker;Babette Gwynn

  • Neonatal gene transfer leads to widespread correction of pathology in a murine model of lysosomal storage disease

    Thomas M. Daly;Carole Vogler;Beth Levy;Mark E. Haskins

  • In vivo distribution of human adipose-derived mesenchymal stem cells in novel xenotransplantation models.

    Todd E. Meyerrose;Daniel A. De Ugarte;A. Alex Hofling;Phillip E. Herrbrich

  • ENZYME REPLACEMENT THERAPY FOR MURINE MUCOPOLYSACCHARIDOSIS TYPE VII

    M S Sands;C Vogler;J W Kyle;J H Grubb

  • Marrow Stromal Cells and Osteoclast Precursors Differentially Contribute to TNF-α-Induced Osteoclastogenesis In Vivo

    Hideki Kitaura;Mark S. Sands;Kunihiko Aya;Ping Zhou

  • Recombinant Adeno-Associated Viral Integration and Genotoxicity: Insights from Animal Models

    Randy J Chandler;Mark S Sands;Charles P Venditti

  • Successive neuron loss in the thalamus and cortex in a mouse model of infantile neuronal ceroid lipofuscinosis

    Catherine Kielar;Lucy Maddox;Ellen Bible;Charlie C Pontikis

  • Neonatal intramuscular injection with recombinant adeno-associated virus results in prolonged beta-glucuronidase expression in situ and correction of liver pathology in mucopolysaccharidosis type VII mice.

    Thomas M. Daly;Torayuki Okuyama;Carole Vogler;Mark E. Haskins

  • A single-base-pair deletion in the beta-glucuronidase gene accounts for the phenotype of murine mucopolysaccharidosis type VII.

    Mark S. Sands;Edward H. Birkenmeier

  • Treatment of murine mucopolysaccharidosis type VII by syngeneic bone marrow transplantation in neonates.

    M S Sands;J E Barker;C Vogler;B Levy

  • Clinical course of sly syndrome (mucopolysaccharidosis type VII)

    Adriana M Montaño;Ngu Lock-Hock;Robert D Steiner;Brett H Graham

  • Enzyme replacement therapy for murine mucopolysaccharidosis type VII leads to improvements in behavior and auditory function.

    L H O'Connor;L C Erway;C A Vogler;W S Sly

  • Central amygdala glucocorticoid receptor action promotes fear-associated CRH activation and conditioning

    Benedict J. Kolber;Marie S. Roberts;Maureen P. Howell;David F. Wozniak

  • CNS-directed AAV2-mediated gene therapy ameliorates functional deficits in a murine model of infantile neuronal ceroid lipofuscinosis.

    Megan A. Griffey;David Wozniak;Michael Wong;Ellen Bible

  • Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking.

    Jessie R. Zhang;Trey Coleman;S. Joshua Langmade;David E. Scherrer

  • VEGF increases engraftment of bone marrow-derived endothelial progenitor cells (EPCs) into vasculature of newborn murine recipients.

    Pampee P. Young;A. Alex Hofling;Mark S. Sands

Frequent Co-Authors

Jonathan D. Cooper
Jonathan D. Cooper Washington University in St. Louis
William S. Sly
William S. Sly Saint Louis University
Kevin K. Ohlemiller
Kevin K. Ohlemiller Washington University in St. Louis
Daniel S. Ory
Daniel S. Ory Washington University in St. Louis
Jan A. Nolta
Jan A. Nolta University of California, Davis
Jin-Moo Lee
Jin-Moo Lee Washington University in St. Louis
Thomas H. Gillingwater
Thomas H. Gillingwater University of Edinburgh
John H. Wolfe
John H. Wolfe University of Pennsylvania
Erik D. Herzog
Erik D. Herzog Washington University in St. Louis
Alexei V. Demchenko
Alexei V. Demchenko Saint Louis University

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