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Ciriaco A. Piccirillo

Ciriaco A. Piccirillo

D-Index & Metrics

Immunology

D-Index
64
Citations
21465
World Ranking
2894
National Ranking
67

Overview

Ciriaco A. Piccirillo is affiliated with the McGill University Health Centre in Canada. Their research spans multiple fields within medicine, with specific emphasis on immunology and microbiology. Throughout their career, they have contributed extensively to the study of immune system function, infectious diseases, molecular biology, oncology, and surgery.

The primary research topics covered in their work include:

  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Immunotherapy and Immune Responses
  • Cancer Immunotherapy and Biomarkers
  • SARS-CoV-2 and COVID-19 Research
  • Renal Diseases and Glomerulopathies
  • COVID-19 Clinical Research Studies

Ciriaco A. Piccirillo has published in numerous scientific venues, with a concentration of work appearing in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Immunology
  • iScience
  • Nature Communications
  • Journal of Allergy and Clinical Immunology

Frequent collaborators in their publications include:

  • Fernando Alvarez
  • Tho-Alfakar Al-Aubodah
  • Mikhaël Attias
  • Bruce Mazer
  • Roman Istomine

Selected recent papers illustrate the scope and focus of their research:

  • Rare Genetic Variants of Large Effect Influence Risk of Type 1 Diabetes, 2020, Diabetes
  • Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome: A systematic review, 2020, Autoimmunity Reviews
  • Inhibiting the MNK1/2-eIF4E axis impairs melanoma phenotype switching and potentiates antitumor immune responses, 2021, Journal of Clinical Investigation
  • Salt Sensing by Serum/Glucocorticoid-Regulated Kinase 1 Promotes Th17-like Inflammatory Adaptation of Foxp3+ Regulatory T Cells, 2020, Cell Reports
  • Unbiased immune profiling reveals a natural killer cell-peripheral nerve axis in fibromyalgia, 2021, Pain

Overall, Ciriaco A. Piccirillo's work intersects immunology and clinical applications, addressing both fundamental immune cell mechanisms and disease-specific pathways across a spectrum that includes autoimmune disorders, cancer, and infectious diseases.

Best Publications

  • CD4 + CD25 + regulatory T cells control Leishmania major persistence and immunity

    Yasmine Belkaid;Yasmine Belkaid;Ciriaco A. Piccirillo;Susana Mendez;Ethan M. Shevach

  • CD4+CD25+ Immunoregulatory T Cells: Gene Expression Analysis Reveals a Functional Role for the Glucocorticoid-Induced TNF Receptor

    Rebecca S McHugh;Matthew J Whitters;Ciriaco A Piccirillo;Deborah A Young

  • Cutting edge: control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells.

    Ciriaco A. Piccirillo;Ethan M. Shevach

  • CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4 T helper cells and hindered by naturally occurring T regulatory cells.

    Paul A. Antony;Ciriaco A. Piccirillo;Akgül Akpinarli;Steven E. Finkelstein

  • Control of T-cell activation by CD4+ CD25+ suppressor T cells.

    Ethan M. Shevach;Rebecca S. McHugh;Ciriaco A. Piccirillo;Angela M. Thornton

  • Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction.

    Qizhi Tang;Jason Yeates Adams;Cristina Penaranda;Kristin Melli

  • CD4+CD25+ Regulatory T Cells Can Mediate Suppressor Function in the Absence of Transforming Growth Factor β1 Production and Responsiveness

    Ciriaco A. Piccirillo;John J. Letterio;Angela M. Thornton;Rebecca S. McHugh

  • Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function.

    Angela M. Thornton;Erin E. Donovan;Ciriaco A. Piccirillo;Ethan M. Shevach

  • The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo

    Julianna Blagih;François Coulombe;Emma E. Vincent;Fanny Dupuy

  • Naturally-occurring CD4+CD25+ immunoregulatory T cells: central players in the arena of peripheral tolerance.

    Ciriaco A Piccirillo;Ethan M Shevach

  • The pathogenesis of schistosomiasis is controlled by cooperating IL-10-producing innate effector and regulatory T cells.

    Matthias Hesse;Ciriaco A. Piccirillo;Yasmine Belkaid;Jeannette Prufer

  • Indoleamine 2,3-Dioxygenase Expression in Human Cancers: Clinical and Immunologic Perspectives

    Jessica Godin-Ethier;Laïla-Aïcha Hanafi;Ciriaco A. Piccirillo;Réjean Lapointe

  • The Inhibitory Effects of Transforming Growth Factor-Beta-1 (TGF-β1) in Autoimmune Diseases

    Gérald J Prud'homme;Ciriaco A Piccirillo

  • Activation requirements for the induction of CD4+CD25+ T cell suppressor function.

    Angela M Thornton;Ciriaco A Piccirillo;Ethan M Shevach

  • Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigens

    Isabelle J. Suffia;Stacie K. Reckling;Ciriaco A. Piccirillo;Romina S. Goldszmid

  • Translational control of immune responses: from transcripts to translatomes

    Ciriaco A Piccirillo;Eva Bjur;Ivan Topisirovic;Nahum Sonenberg

  • CCR5-dependent homing of naturally occurring CD4+ regulatory T cells to sites of Leishmania major infection favors pathogen persistence

    Ekaterina Yurchenko;Michael Tritt;Valerie Hay;Ethan M. Shevach

  • Cornerstone of peripheral tolerance: naturally occurring CD4+CD25+ regulatory T cells.

    Ciriaco A Piccirillo;Angela M Thornton

  • Impairment of dendritic cell function by excretory‐secretory products: A potential mechanism for nematode‐induced immunosuppression

    Mariela Segura;Zhong Su;Ciriaco Piccirillo;Mary M. Stevenson

  • TGF-beta1 somatic gene therapy prevents autoimmune disease in nonobese diabetic mice.

    Ciriaco A. Piccirillo;Yigang Chang;Gérald J. Prud’homme

Frequent Co-Authors

Ethan M. Shevach
Ethan M. Shevach National Institute of Allergy and Infectious Diseases
Megan K. Levings
Megan K. Levings University of British Columbia
Constantin Polychronakos
Constantin Polychronakos McGill University Health Centre
Gerald J. Prud'homme
Gerald J. Prud'homme University of Toronto
Nahum Sonenberg
Nahum Sonenberg McGill University
Yasmine Belkaid
Yasmine Belkaid National Institute of Allergy and Infectious Diseases
Wilson H. Miller
Wilson H. Miller McGill University
Ivan Topisirovic
Ivan Topisirovic McGill University
Mark I. Greene
Mark I. Greene University of Pennsylvania
Wassim Kassouf
Wassim Kassouf McGill University

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