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Gerald J. Prud'homme

Gerald J. Prud'homme

D-Index & Metrics

Biology and Biochemistry

D-Index
49
Citations
8628
World Ranking
18029
National Ranking
628

Overview

Gerald J. Prud'homme is affiliated with the University of Toronto in Canada and focuses their research primarily within the fields of Medicine, and Biochemistry, Genetics and Molecular Biology. Their work spans various subfields, including Surgery, Genetics, Endocrinology, Diabetes and Metabolism, Nephrology, and Physiology.

Their research extensively covers topics related to pancreatic function and diabetes, parathyroid disorders and treatments, genetic syndromes and imprinting, biomedical research and pathophysiology, diet, metabolism and disease, liver disease diagnosis and treatment, as well as pancreatitis pathology and treatment.

Recent publications authored by Gerald J. Prud'homme include:

  • Pathobiology of the Klotho Antiaging Protein and Therapeutic Considerations, 2022, Frontiers in Aging
  • Anti-Inflammatory Role of the Klotho Protein and Relevance to Aging, 2024, Cells
  • Systemic Klotho Therapy Protects Against Insulitis and Enhances Beta-Cell Mass in NOD Mice, 2020, Biochemical and Biophysical Research Communications

These publications contribute to understanding mechanisms of aging, inflammation, and pancreatic function, particularly focusing on the Klotho protein and its therapeutic potential.

Gerald J. Prud'homme has collaborated regularly with several coauthors, including:

  • Qinghua Wang
  • Yunzhi Ni
  • Zhihong Wang
  • Qiaoli Cui

Their work frequently appears in scientific journals such as Frontiers in Aging, Journal of Endocrinology, Preprints.org, Diabetes Obesity and Metabolism, and Cells.

This profile reflects Gerald J. Prud'homme's ongoing contributions to biomedical research, particularly in the intersecting areas of endocrine function, aging, and metabolic disease. Their research output shows a sustained focus on diseases related to pancreatic function and metabolic regulation, with an emphasis on molecular and physiological mechanisms as well as potential therapeutic strategies.

Best Publications

  • Pathobiology of transforming growth factor beta in cancer, fibrosis and immunologic disease, and therapeutic considerations.

    Gérald J Prud'homme

  • GABA exerts protective and regenerative effects on islet beta cells and reverses diabetes

    Nepton Soltani;Hongmin Qiu;Mila Aleksic;Yelena Glinka

  • The Inhibitory Effects of Transforming Growth Factor-Beta-1 (TGF-β1) in Autoimmune Diseases

    Gérald J Prud'homme;Ciriaco A Piccirillo

  • Neuropilins are multifunctional coreceptors involved in tumor initiation, growth, metastasis and immunity

    Gerald J Prud'homme;Yelena Glinka

  • Neuropilin‐1 is a receptor for transforming growth factor β‐1, activates its latent form, and promotes regulatory T cell activity

    Yelena Glinka;Gérald J. Prud'homme

  • Electroporation-enhanced nonviral gene transfer for the prevention or treatment of immunological, endocrine and neoplastic diseases.

    Gerald J. Prud'homme;Yelena Glinka;Amir S. Khan;Ruxandra Draghia-Akli

  • Identification of a B cell differentiation factor(s) spontaneously produced by proliferating T cells in murine lupus strains of the lpr/lpr genotype.

    G J Prud'Homme;C L Park;T M Fieser;R Kofler

  • Neuropilin-1 exerts co-receptor function for TGF-beta-1 on the membrane of cancer cells and enhances responses to both latent and active TGF-beta.

    Yelena Glinka;Snejana Stoilova;Nada Mohammed;Gérald J. Prud'homme

  • TGF-beta1 somatic gene therapy prevents autoimmune disease in nonobese diabetic mice.

    Ciriaco A. Piccirillo;Yigang Chang;Gérald J. Prud’homme

  • Treatment of murine lupus with cDNA encoding IFN-γR/Fc

    Brian R. Lawson;Gerald J. Prud’homme;Yigang Chang;Humphrey A. Gardner

  • Breast cancer stem-like cells are inhibited by a non-toxic aryl hydrocarbon receptor agonist.

    Gérald J. Prud'homme;Gérald J. Prud'homme;Yelena Glinka;Yelena Glinka;Anna Toulina;Anna Toulina;Olga Ace;Olga Ace

  • GABA promotes human β-cell proliferation and modulates glucose homeostasis

    Indri Purwana;Juan Zheng;Xiaoming Li;Marielle Deurloo

  • Cancer Stem Cells and Novel Targets for Antitumor Strategies

    Gérald J Prud'homme

  • Quantitative polymerase chain reaction analysis reveals marked overexpression of interleukin-1β, interleukin-10 and interferon-γ mRNA in the lymph nodes of lupus-prone mice

    Gerald J. Prud'homme;Dwight H. Kono;Argyrios N. Theofilopoulos

  • DNA vaccination against tumors

    Gérald J. Prud'homme

  • Immunological GABAergic interactions and therapeutic applications in autoimmune diseases.

    Gérald J. Prud'homme;Gérald J. Prud'homme;Yelena Glinka;Qinghua Wang

  • B cell dependence on and response to accessory signals in murine lupus strains.

    G J Prud'homme;R S Balderas;F J Dixon;A N Theofilopoulos

  • Gene therapy of autoimmune diseases with vectors encoding regulatory cytokines or inflammatory cytokine inhibitors.

    Gérald J. Prud'homme

  • Gene therapy of diabetes using a novel GLP-1/IgG1-Fc fusion construct normalizes glucose levels in db/db mice

    M Kumar;M Kumar;Y Hunag;Y Hunag;Y Glinka;G J Prud'Homme

  • Prevention of autoimmune diabetes by intramuscular gene therapy with a nonviral vector encoding an interferon-gamma receptor/IgG1 fusion protein.

    G J Prud'homme;Y Chang

Frequent Co-Authors

Argyrios N. Theofilopoulos
Argyrios N. Theofilopoulos Scripps Research Institute
Ciriaco A. Piccirillo
Ciriaco A. Piccirillo McGill University Health Centre
David W. Hedley
David W. Hedley Princess Margaret Cancer Centre
Frank J. Dixon
Frank J. Dixon Scripps Health
Dwight H. Kono
Dwight H. Kono Scripps Research Institute
George M. Yousef
George M. Yousef University of Toronto
Mark A. Atkinson
Mark A. Atkinson University of Florida
Heyu Ni
Heyu Ni University of Toronto
Dale L. Greiner
Dale L. Greiner University of Massachusetts Chan Medical School
Laura D. Baker
Laura D. Baker Wake Forest University

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