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D-Index & Metrics

Biology and Biochemistry

D-Index
72
Citations
17375
World Ranking
6349
National Ranking
487

Overview

Ian Zachary is affiliated with University College London in the United Kingdom. Their research spans multiple fields with a primary focus on Medicine and Biochemistry, Genetics, and Molecular Biology. Within these disciplines, the scientist has explored various subfields including Molecular Biology, Pediatrics, Perinatology and Child Health, Obstetrics and Gynecology, Cancer Research, and Cardiology and Cardiovascular Medicine.

Their research topics cover a range of biomedical and clinical themes, most notably:

  • Angiogenesis and VEGF in Cancer
  • Pregnancy and preeclampsia studies
  • Prenatal Screening and Diagnostics
  • Birth, Development, and Health
  • Cancer, Hypoxia, and Metabolism
  • Retinal Diseases and Treatments
  • Retinal Imaging and Analysis

Ian Zachary has contributed to several scholarly publications, with recent papers including:

  • "Mechanisms of Acquired Resistance to Anti-VEGF Therapy for Neovascular Eye Diseases," 2023, Investigative Ophthalmology & Visual Science
  • "Maternal PlGF and umbilical Dopplers predict pregnancy outcomes at diagnosis of early-onset fetal growth restriction," 2023, Journal of Clinical Investigation
  • "Comparison of Efficiency and Function of Vascular Endothelial Growth Factor Adenovirus Vectors in Endothelial Cells for Gene Therapy of Placental Insufficiency," 2020, Human Gene Therapy
  • "Bcar1/p130Cas is essential for ventricular development and neural crest cell remodelling of the cardiac outflow tract," 2021, Cardiovascular Research
  • "Peptides Derived from Vascular Endothelial Growth Factor B Show Potent Binding to Neuropilin-1," 2021, ChemBioChem

The scientist frequently publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), Investigative Ophthalmology & Visual Science, Journal of Clinical Investigation, Human Gene Therapy, and Journal of Cell Science.

Collaborations have featured multiple co-authors who have worked with Ian Zachary on at least three occasions. These include Rebecca Spencer, Donald Peebles, Anna L. David, John F. Martin, and Paul Frankel.

Best Publications

  • Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family.

    Ian Zachary;Georgia Gliki

  • The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease

    David I R Holmes;Ian Zachary

  • Vascular Endothelial Growth Factor Stimulates Tyrosine Phosphorylation and Recruitment to New Focal Adhesions of Focal Adhesion Kinase and Paxillin in Endothelial Cells

    Husna Abedi;Ian Zachary

  • Focal adhesion kinase (p125FAK): A point of convergence in the action of neuropeptides, integrins, and oncogenes

    Ian Zachary;Enrique Rozengurt

  • Role of Angiogenesis in Cardiovascular Disease A Critical Appraisal

    Rohit Khurana;Michael Simons;John F. Martin;Ian C. Zachary

  • VEGF signalling: integration and multi-tasking in endothelial cell biology

    Zachary I

  • Neuropilins: structure, function and role in disease

    Caroline Pellet-Many;Paul Frankel;Haiyan Jia;Ian Zachary

  • Signaling mechanisms mediating vascular protective actions of vascular endothelial growth factor

    Ian Zachary

  • Bombesin, vasopressin, and endothelin stimulation of tyrosine phosphorylation in Swiss 3T3 cells. Identification of a novel tyrosine kinase as a major substrate.

    I Zachary;J Sinnett-Smith;E Rozengurt

  • Bombesin stimulation of p125 focal adhesion kinase tyrosine phosphorylation. Role of protein kinase C, Ca2+ mobilization, and the actin cytoskeleton.

    J Sinnett-Smith;I Zachary;A M Valverde;E Rozengurt

  • Vascular endothelial growth factor stimulates prostacyclin production and activation of cytosolic phospholipase A2 in endothelial cells via p42/p44 mitogen-activated protein kinase

    Caroline Wheeler-Jones;Robin Abu-Ghazaleh;Rosario Cospedal;Rebecca A Houliston

  • Neuroprotective Role of Vascular Endothelial Growth Factor: Signalling Mechanisms, Biological Function, and Therapeutic Potential

    Ian Zachary

  • VEGF gene transfer reduces intimal thickening via increased production of nitric oxide in carotid arteries.

    Marja Laitinen;Ian Zachary;Georg Breier;Timo Pakkanen

  • Correlation of increased vascular endothelial growth factor with neovascularization and permeability in ischemic central vein occlusion.

    Shelley R. Boyd;Ian Zachary;Usha Chakravarthy;George J. Allen

  • Bombesin, vasopressin, and endothelin rapidly stimulate tyrosine phosphorylation of the focal adhesion-associated protein paxillin in Swiss 3T3 cells

    I Zachary;J Sinnett-Smith;C E Turner;E Rozengurt

  • Vascular Protection A Novel Nonangiogenic Cardiovascular Role for Vascular Endothelial Growth Factor

    Ian Zachary;Anthony Mathur;Seppo Yla-Herttuala;John Martin

  • High-affinity receptors for peptides of the bombesin family in Swiss 3T3 cells.

    Ian Zachary;Enrique Rozengurt

  • Src mediates stimulation by vascular endothelial growth factor of the phosphorylation of focal adhesion kinase at tyrosine 861, and migration and anti-apoptosis in endothelial cells.

    Robin Abu-Ghazaleh;Jahangir Kabir;Haiyan Jia;Mel Lobo

  • Vascular Endothelial Growth Factor–Regulated Gene Expression in Endothelial Cells: KDR-Mediated Induction of Egr3 and the Related Nuclear Receptors Nur77, Nurr1, and Nor1

    Dan Liu;Haiyan Jia;David Ian Roderick Holmes;Anita Stannard

  • Angiogenesis-Dependent and Independent Phases of Intimal Hyperplasia

    Rohit Khurana;Zhenwu Zhuang;Shalini Bhardwaj;Masahiro Murakami

Frequent Co-Authors

Enrique Rozengurt
Enrique Rozengurt University of California, Los Angeles
Sreenivasan Ponnambalam
Sreenivasan Ponnambalam University of Leeds
Seppo Ylä-Herttuala
Seppo Ylä-Herttuala University of Eastern Finland
James Sinnett-Smith
James Sinnett-Smith University of California, Los Angeles
Michael Simons
Michael Simons Yale University
Andrew Steptoe
Andrew Steptoe University College London
Lieve Moons
Lieve Moons KU Leuven
Alex Bobik
Alex Bobik Baker IDI Heart and Diabetes Institute
Werner Risau
Werner Risau Max Planck Society

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