His primary scientific interests are in Protein kinase C, Bombesin, Molecular biology, Signal transduction and Protein kinase A. In his articles, James Sinnett-Smith combines various disciplines, including Protein kinase C and Protein kinase D1. His Bombesin research incorporates elements of Growth factor and Platelet-derived growth factor receptor.
His work carried out in the field of Molecular biology brings together such families of science as Gustducin, Tyrosine phosphorylation, Receptor, Taste receptor and Phosphorylation. His Protein kinase A study combines topics from a wide range of disciplines, such as Phorbol and Diacylglycerol kinase. James Sinnett-Smith interconnects Endocrinology and Internal medicine in the investigation of issues within Cancer research.
His scientific interests lie mostly in Cell biology, Cancer research, Protein kinase C, Phosphorylation and Internal medicine. His work on Mitogen-activated protein kinase kinase, Signal transduction and Crosstalk as part of general Cell biology study is frequently connected to Protein kinase D1, therefore bridging the gap between diverse disciplines of science and establishing a new relationship between them. His research integrates issues of mTORC1, Protein kinase B, PI3K/AKT/mTOR pathway, Pancreatic cancer and MAPK/ERK pathway in his study of Cancer research.
His Protein kinase C study incorporates themes from Molecular biology, Bombesin and Protein kinase A. The Phosphorylation study combines topics in areas such as Angiotensin II and G protein-coupled receptor. His Internal medicine research focuses on Endocrinology and how it relates to Growth factor.
His primary areas of investigation include Cancer research, Cell biology, Pancreatic ductal adenocarcinoma, Internal medicine and Pancreatic cancer. His studies deal with areas such as Receptor, Nuclear localization sequence, CYR61, CTGF and Cyclin-dependent kinase 6 as well as Cancer research. His work on PROTEIN KINASE D, Cyclin-dependent kinase 9 and Phosphorylation as part of general Cell biology study is frequently linked to Protein kinase D1 and Growth promoting, bridging the gap between disciplines.
His Phosphorylation research is multidisciplinary, incorporating perspectives in Molecular biology, Distribution and Intracellular. His biological study spans a wide range of topics, including Endocrinology and Oncology. His PI3K/AKT/mTOR pathway research is under the purview of Signal transduction.
James Sinnett-Smith mainly focuses on Pancreatic cancer, Cancer research, Pancreas, Internal medicine and Endocrinology. His studies in Pancreatic cancer integrate themes in fields like Diacylglycerol kinase, ANLN, Hormone-sensitive lipase, Surgical oncology and Cachexia. His Cancer research research also works with subjects such as
His Pancreas research includes elements of Inflammation, Obesity and Fibrosis. His research in Internal medicine intersects with topics in Diabetes mellitus and Histopathology. His Endocrinology study frequently intersects with other fields, such as mTORC1.
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Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells
S. Vincent Wu;Nora Rozengurt;Moon Yang;Steven H. Young.
Proceedings of the National Academy of Sciences of the United States of America (2002)
Bombesin stimulation of DNA synthesis and cell division in cultures of Swiss 3T3 cells.
Enrique Rozengurt;James Sinnett-Smith.
Proceedings of the National Academy of Sciences of the United States of America (1983)
Molecular cloning and characterization of protein kinase D: a target for diacylglycerol and phorbol esters with a distinctive catalytic domain
A M Valverde;J Sinnett-Smith;J Van Lint;E Rozengurt.
Proceedings of the National Academy of Sciences of the United States of America (1994)
Bombesin, vasopressin, and endothelin stimulation of tyrosine phosphorylation in Swiss 3T3 cells. Identification of a novel tyrosine kinase as a major substrate.
I Zachary;J Sinnett-Smith;E Rozengurt.
Journal of Biological Chemistry (1992)
Bombesin stimulation of p125 focal adhesion kinase tyrosine phosphorylation. Role of protein kinase C, Ca2+ mobilization, and the actin cytoskeleton.
J Sinnett-Smith;I Zachary;A M Valverde;E Rozengurt.
Journal of Biological Chemistry (1993)
Metformin disrupts crosstalk between G protein-coupled receptor and insulin receptor signaling systems and inhibits pancreatic cancer growth.
Krisztina Kisfalvi;Guido Eibl;James Sinnett-Smith;Enrique Rozengurt.
Cancer Research (2009)
Diacylglycerol stimulates DNA synthesis and cell division in mouse 3T3 cells: role of Ca2+-sensitive phospholipid-dependent protein kinase
Enrique Rozengurt;Angeles Rodriguez-Pena;Maurice Coombs;James Sinnett-Smith.
Proceedings of the National Academy of Sciences of the United States of America (1984)
Crosstalk between Insulin/Insulin-like Growth Factor-1 Receptors and G Protein-Coupled Receptor Signaling Systems: A Novel Target for the Antidiabetic Drug Metformin in Pancreatic Cancer
Enrique Rozengurt;James Sinnett-Smith;Krisztina Kisfalvi.
Clinical Cancer Research (2010)
Early events elicited by bombesin and structurally related peptides in quiescent Swiss 3T3 cells. I. Activation of protein kinase C and inhibition of epidermal growth factor binding.
I Zachary;J W Sinnett-Smith;E Rozengurt.
Journal of Cell Biology (1986)
Protein kinase D (PKD) activation in intact cells through a protein kinase C-dependent signal transduction pathway.
J. L. Zugaza;J. Sinnett-Smith;J. Van Lint;E. Rozengurt.
The EMBO Journal (1996)
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