What is he best known for?
The fields of study he is best known for:
- Enzyme
- Signal transduction
- Phosphorylation
His primary scientific interests are in Protein kinase C, Bombesin, Molecular biology, Signal transduction and Protein kinase A.
In his articles, James Sinnett-Smith combines various disciplines, including Protein kinase C and Protein kinase D1.
His Bombesin research incorporates elements of Growth factor and Platelet-derived growth factor receptor.
His work carried out in the field of Molecular biology brings together such families of science as Gustducin, Tyrosine phosphorylation, Receptor, Taste receptor and Phosphorylation.
His Protein kinase A study combines topics from a wide range of disciplines, such as Phorbol and Diacylglycerol kinase.
James Sinnett-Smith interconnects Endocrinology and Internal medicine in the investigation of issues within Cancer research.
His most cited work include:
- Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells (408 citations)
- Bombesin stimulation of DNA synthesis and cell division in cultures of Swiss 3T3 cells. (396 citations)
- Molecular cloning and characterization of protein kinase D: a target for diacylglycerol and phorbol esters with a distinctive catalytic domain (356 citations)
What are the main themes of his work throughout his whole career to date?
His scientific interests lie mostly in Cell biology, Cancer research, Protein kinase C, Phosphorylation and Internal medicine.
His work on Mitogen-activated protein kinase kinase, Signal transduction and Crosstalk as part of general Cell biology study is frequently connected to Protein kinase D1, therefore bridging the gap between diverse disciplines of science and establishing a new relationship between them.
His research integrates issues of mTORC1, Protein kinase B, PI3K/AKT/mTOR pathway, Pancreatic cancer and MAPK/ERK pathway in his study of Cancer research.
His Protein kinase C study incorporates themes from Molecular biology, Bombesin and Protein kinase A.
The Phosphorylation study combines topics in areas such as Angiotensin II and G protein-coupled receptor.
His Internal medicine research focuses on Endocrinology and how it relates to Growth factor.
He most often published in these fields:
- Cell biology (34.25%)
- Cancer research (30.94%)
- Protein kinase C (28.18%)
What were the highlights of his more recent work (between 2016-2020)?
- Cancer research (30.94%)
- Cell biology (34.25%)
- Pancreatic ductal adenocarcinoma (5.52%)
In recent papers he was focusing on the following fields of study:
His primary areas of investigation include Cancer research, Cell biology, Pancreatic ductal adenocarcinoma, Internal medicine and Pancreatic cancer.
His studies deal with areas such as Receptor, Nuclear localization sequence, CYR61, CTGF and Cyclin-dependent kinase 6 as well as Cancer research.
His work on PROTEIN KINASE D, Cyclin-dependent kinase 9 and Phosphorylation as part of general Cell biology study is frequently linked to Protein kinase D1 and Growth promoting, bridging the gap between disciplines.
His Phosphorylation research is multidisciplinary, incorporating perspectives in Molecular biology, Distribution and Intracellular.
His biological study spans a wide range of topics, including Endocrinology and Oncology.
His PI3K/AKT/mTOR pathway research is under the purview of Signal transduction.
Between 2016 and 2020, his most popular works were:
- Yes-associated protein (YAP) in pancreatic cancer: at the epicenter of a targetable signaling network associated with patient survival (61 citations)
- Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice. (60 citations)
- Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice. (60 citations)
In his most recent research, the most cited papers focused on:
- Enzyme
- Signal transduction
- Phosphorylation
James Sinnett-Smith mainly focuses on Pancreatic cancer, Cancer research, Pancreas, Internal medicine and Endocrinology.
His studies in Pancreatic cancer integrate themes in fields like Diacylglycerol kinase, ANLN, Hormone-sensitive lipase, Surgical oncology and Cachexia.
His Cancer research research also works with subjects such as
- CYR61 which intersects with area such as Neurotensin, PI3K/AKT/mTOR pathway, Signal transduction and Insulin,
- CTGF which intersects with area such as Cell growth and Statin.
His Pancreas research includes elements of Inflammation, Obesity and Fibrosis.
His research in Internal medicine intersects with topics in Diabetes mellitus and Histopathology.
His Endocrinology study frequently intersects with other fields, such as mTORC1.
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