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Biology and Biochemistry

D-Index
53
Citations
10311
World Ranking
16147
National Ranking
6690

Overview

James Sinnett-Smith is affiliated with the University of California, Los Angeles in the United States. Their research spans multiple areas within biochemistry, genetics, molecular biology, and medicine, with a focus on molecular pathways related to cancer and cell biology.

Their work addresses specific topics such as Hippo pathway signaling and YAP/TAZ, cancer-related molecular pathways, lipid metabolism and biosynthesis, cancer, lipids, and metabolism, cell adhesion molecules research, platelet disorders and treatments, and PI3K/AKT/mTOR signaling in cancer.

Frequent publication venues for Sinnett-Smith include The Journal of Immunology, Gastroenterology, the American Journal of Physiology-Cell Physiology, Molecular Cancer Therapeutics, and the American Journal of Physiology-Gastrointestinal and Liver Physiology.

Coauthors who have regularly collaborated with Sinnett-Smith include Enrique Rozengurt, Elaine F. Reed, Tarique Anwar, Yaroslav Teper, and Guido Eibl.

Selected recent papers authored or coauthored by Sinnett-Smith are listed below:

  • Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells: Implications for Targeted Therapy, 2022, Molecular Cancer Therapeutics
  • Lipophilic statins inhibit YAP coactivator transcriptional activity in HCC cells through Rho-mediated modulation of actin cytoskeleton, 2023, American Journal of Physiology-Gastrointestinal and Liver Physiology
  • Low dosage combination treatment with metformin and simvastatin inhibits obesity-promoted pancreatic cancer development in male KrasG12D mice, 2023, Scientific Reports
  • Ligation of HLA Class I Molecules Induces YAP Activation through Src in Human Endothelial Cells, 2020, The Journal of Immunology
  • Lipophilic Statins Inhibit YAP Nuclear Localization, Coactivator Activity, and Migration in Response to Ligation of HLA Class I Molecules in Endothelial Cells: Role of YAP Multisite Phosphorylation, 2023, The Journal of Immunology

Sinnett-Smith's research contributions are concentrated in several subfields, including cell biology, molecular biology, oncology, biochemistry, and cancer research. Their publications reflect a consistent interest in investigating molecular mechanisms involving the Hippo pathway, cancer signaling, and metabolism, with an emphasis on both basic and translational biomedical science.

Best Publications

  • Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells

    S. Vincent Wu;Nora Rozengurt;Moon Yang;Steven H. Young

  • Bombesin stimulation of DNA synthesis and cell division in cultures of Swiss 3T3 cells.

    Enrique Rozengurt;James Sinnett-Smith

  • Molecular cloning and characterization of protein kinase D: a target for diacylglycerol and phorbol esters with a distinctive catalytic domain

    A M Valverde;J Sinnett-Smith;J Van Lint;E Rozengurt

  • Bombesin, vasopressin, and endothelin stimulation of tyrosine phosphorylation in Swiss 3T3 cells. Identification of a novel tyrosine kinase as a major substrate.

    I Zachary;J Sinnett-Smith;E Rozengurt

  • Metformin disrupts crosstalk between G protein-coupled receptor and insulin receptor signaling systems and inhibits pancreatic cancer growth.

    Krisztina Kisfalvi;Guido Eibl;James Sinnett-Smith;Enrique Rozengurt

  • Bombesin stimulation of p125 focal adhesion kinase tyrosine phosphorylation. Role of protein kinase C, Ca2+ mobilization, and the actin cytoskeleton.

    J Sinnett-Smith;I Zachary;A M Valverde;E Rozengurt

  • Crosstalk between Insulin/Insulin-like Growth Factor-1 Receptors and G Protein-Coupled Receptor Signaling Systems: A Novel Target for the Antidiabetic Drug Metformin in Pancreatic Cancer

    Enrique Rozengurt;James Sinnett-Smith;Krisztina Kisfalvi

  • Diacylglycerol stimulates DNA synthesis and cell division in mouse 3T3 cells: role of Ca2+-sensitive phospholipid-dependent protein kinase

    Enrique Rozengurt;Angeles Rodriguez-Pena;Maurice Coombs;James Sinnett-Smith

  • Early events elicited by bombesin and structurally related peptides in quiescent Swiss 3T3 cells. I. Activation of protein kinase C and inhibition of epidermal growth factor binding.

    I Zachary;J W Sinnett-Smith;E Rozengurt

  • Protein kinase D (PKD) activation in intact cells through a protein kinase C-dependent signal transduction pathway.

    J. L. Zugaza;J. Sinnett-Smith;J. Van Lint;E. Rozengurt

  • Bombesin, vasopressin, and endothelin rapidly stimulate tyrosine phosphorylation of the focal adhesion-associated protein paxillin in Swiss 3T3 cells

    I Zachary;J Sinnett-Smith;C E Turner;E Rozengurt

  • Expression and Characterization of PKD, a Phorbol Ester and Diacylglycerol-stimulated Serine Protein Kinase

    Johan Van Lint;James Sinnett-Smith;Enrique Rozengurt

  • Bombesin, Vasopressin, Endothelin, Bradykinin, and Platelet-derived Growth Factor Rapidly Activate Protein Kinase D through a Protein Kinase C-dependent Signal Transduction Pathway

    José L. Zugaza;Richard T. Waldron;James Sinnett-Smith;Enrique Rozengurt

  • A novel small molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo

    Kuzhuvelil B. Harikumar;Ajaikumar B. Kunnumakkara;Nobuo Ochi;Zhimin Tong

  • Bombesin, vasopressin, and endothelin rapidly stimulate tyrosine phosphorylation in intact Swiss 3T3 cells

    Ian Zachary;Joan Gil;Wolfram Lehmann;James Sinnett-Smith

  • Early events elicited by bombesin and structurally related peptides in quiescent Swiss 3T3 cells. II. Changes in Na+ and Ca2+ fluxes, Na+/K+ pump activity, and intracellular pH.

    Stanley A. Mendoza;Jerry A. Schneider;Abelardo Lopez-Rivas;James W. Sinnett-Smith

  • Different Patterns of Akt and ERK Feedback Activation in Response to Rapamycin, Active-Site mTOR Inhibitors and Metformin in Pancreatic Cancer Cells

    Heloisa P. Soares;Yang Ni;Yang Ni;Krisztina Kisfalvi;James Sinnett-Smith

  • Platelet-derived growth factor treatment decreases the affinity of the epidermal growth factor receptors of Swiss 3T3 cells.

    M K Collins;J W Sinnett-Smith;E Rozengurt

  • Ca2+-mobilizing actions of platelet-derived growth factor differ from those of bombesin and vasopressin in Swiss 3T3 mouse cells

    Abelardo Lopez-Rivas;Stanley A. Mendoza;Eewa Nanberg;James Sinnett-Smith

  • Production of PDGF-like growth factor by breast cancer cell lines

    Enrique Rozengurt;James Sinnett-Smith;Joyce Taylor-Papadimitriou

Frequent Co-Authors

Enrique Rozengurt
Enrique Rozengurt University of California, Los Angeles
James J. Yoo
James J. Yoo Wake Forest University
Ian Zachary
Ian Zachary University College London
Samuel W. French
Samuel W. French UCLA Medical Center
Stephen J. Pandol
Stephen J. Pandol Cedars-Sinai Medical Center
Catia Sternini
Catia Sternini University of California, Los Angeles
Isabel Fabregat
Isabel Fabregat University of Barcelona
Bokyung Sung
Bokyung Sung The University of Texas Health Science Center at Houston
Ajaikumar B. Kunnumakkara
Ajaikumar B. Kunnumakkara Indian Institute of Technology Guwahati
Charalabos Pothoulakis
Charalabos Pothoulakis University of California, Los Angeles

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