World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
97
Citations
29954
World Ranking
1770
National Ranking
978

Medicine

D-Index
97
Citations
29955
World Ranking
9399
National Ranking
4848

Overview

Charalabos Pothoulakis is affiliated with the University of California, Los Angeles in the United States. Their research spans multiple areas within medicine and biochemistry, genetics, and molecular biology.

The primary fields of study include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

The scientist's work extends to several subfields of study:

  • Molecular Biology
  • Immunology
  • Neurology
  • Infectious Diseases
  • Cancer Research

The main research topics covered by Charalabos Pothoulakis are:

  • Clostridium difficile and Clostridium perfringens research
  • Gastrointestinal motility and disorders
  • Extracellular vesicles in disease
  • MicroRNA in disease regulation
  • Barrier Structure and Function Studies
  • Circular RNAs in diseases
  • Phagocytosis and Immune Regulation

Frequent co-authors of Charalabos Pothoulakis include:

  • Carl R. Rankin
  • Ivy Ka Man Law
  • Elizabeth J. Videlock
  • Artin Soroosh
  • Jill M. Hoffman

They have published extensively in several scientific venues, with a notable presence in:

  • Gastroenterology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • American Journal of Physiology-Gastrointestinal and Liver Physiology
  • Cell Death and Disease
  • Proceedings of the National Academy of Sciences

Some recent papers authored include:

  • The Colonic Mucosal MicroRNAs, MicroRNA-219a-5p, and MicroRNA-338-3p Are Downregulated in Irritable Bowel Syndrome and Are Associated With Barrier Function and MAPK Signaling (2021, Gastroenterology)
  • Mice expressing fluorescent PAR 2 reveal that endocytosis mediates colonic inflammation and pain (2022, Proceedings of the National Academy of Sciences)
  • Role and mechanisms of exosomal miRNAs in IBD pathophysiology (2020, American Journal of Physiology-Gastrointestinal and Liver Physiology)
  • Blockage of protease-activated receptor 2 exacerbates inflammation in high-fat environment partly through autophagy inhibition (2020, American Journal of Physiology-Gastrointestinal and Liver Physiology)
  • Posttranslational modifications as therapeutic targets for intestinal disorders (2021, Pharmacological Research)

Best Publications

  • Principles and clinical implications of the brain-gut-enteric microbiota axis.

    Sang H. Rhee;Charalabos Pothoulakis;Emeran A. Mayer

  • Lin28A and Lin28B Inhibit let-7 MicroRNA Biogenesis by Distinct Mechanisms

    Elena Piskounova;Christos Polytarchou;James E. Thornton;James E. Thornton;Robert J. LaPierre;Robert J. LaPierre

  • Mechanisms and Metabolic Implications of Regional Differences among Fat Depots

    Tamara Tchkonia;Thomas Thomou;Yi Zhu;Iordanes Karagiannides

  • Tachykinins and Their Receptors: Contributions to Physiological Control and the Mechanisms of Disease

    Martin S Steinhoff;Bengt von Mentzer;Pierangelo Geppetti;Charalabos Pothoulakis

  • Saccharomyces boulardii protease inhibits the effects of Clostridium difficile toxins A and B in human colonic mucosa.

    I Castagliuolo;M F Riegler;L Valenick;J T LaMont

  • Enteric Glia Regulate Intestinal Barrier Function and Inflammation Via Release of S-Nitrosoglutathione

    Tor C. Savidge;Tor C. Savidge;Paul Newman;Charalabos Pothoulakis;Anne Ruhl

  • Trefoil Peptide Protection of Intestinal Epithelial Barrier Function: Cooperative Interaction With Mucin Glycoprotein

    Heather Kindon;Charalabos Pothoulakis;Lars Thim;Kathryn Lynch-Devaney

  • Clostridium difficile toxin A perturbs cytoskeletal structure and tight junction permeability of cultured human intestinal epithelial monolayers.

    G Hecht;C Pothoulakis;J T LaMont;J L Madara

  • Clostridium difficile toxin B is more potent than toxin A in damaging human colonic epithelium in vitro.

    M Riegler;R Sedivy;C Pothoulakis;G Hamilton

  • Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns.

    Tamara Tchkonia;Marc Lenburg;Thomas Thomou;Nino Giorgadze

  • Neuropeptide substance P and the immune response

    Alireza Mashaghi;Anna Marmalidou;Mohsen Tehrani;Peter M. Grace

  • Saccharomyces boulardii inhibits Clostridium difficile toxin A binding and enterotoxicity in rat ileum.

    Charalabos Pothoulakis;Ciaran P. Kelly;Manher A. Joshi;Ning Gao

  • Efficacy and safety of the probiotic Saccharomyces boulardii for the prevention and therapy of gastrointestinal disorders

    Theodoros Kelesidis;Charalabos Pothoulakis

  • Role of substance P and the neurokinin 1 receptor in acute pancreatitis and pancreatitis-associated lung injury

    Madhav Bhatia;Ashok K. Saluja;Bernd Hofbauer;Jean Louis Frossard

  • Repeated exposure to water avoidance stress in rats: a new model for sustained visceral hyperalgesia

    Sylvie Bradesi;Ines Schwetz;Helena S. Ennes;Christophe M. R. Lamy

  • Treatment with intravenously administered gamma globulin of chronic relapsing colitis induced by Clostridium difficile toxin

    Donald Y.M. Leung;Ciaran P. Kelly;Mark Boguniewicz;Charalabos Pothoulakis

  • Acute stress causes mucin release from rat colon: role of corticotropin releasing factor and mast cells

    I. Castagliuolo;J. T. Lamont;B. Qiu;S. M. Fleming

  • Saccharomyces boulardii protease inhibits Clostridium difficile toxin A effects in the rat ileum.

    I Castagliuolo;J T LaMont;S T Nikulasson;C Pothoulakis

  • Saccharomyces boulardii stimulates intestinal immunoglobulin A immune response to Clostridium difficile toxin A in mice.

    Amir Qamar;Samer Aboudola;Michel Warny;Pierre Michetti

  • Clostridium difficile toxoid vaccine in recurrent C. difficile-associated diarrhea

    Stavros Sougioultzis;Lorraine Kyne;Denise Drudy;Sarah Keates

Frequent Co-Authors

Dimitrios Iliopoulos
Dimitrios Iliopoulos University of California, Los Angeles
Ignazio Castagliuolo
Ignazio Castagliuolo University of Padua
Ciaran P. Kelly
Ciaran P. Kelly Beth Israel Deaconess Medical Center
Emeran A. Mayer
Emeran A. Mayer University of California, Los Angeles
Mary Pat Moyer
Mary Pat Moyer Incell Corporation (United States)
Stephan R. Targan
Stephan R. Targan Cedars-Sinai Medical Center
Lin Chang
Lin Chang University of California, Los Angeles
Michael J. O'Brien
Michael J. O'Brien Tulane University
Tor C. Savidge
Tor C. Savidge Baylor College of Medicine
Jeremy J.W. Chen
Jeremy J.W. Chen National Chung Hsing University

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