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Isabel Fabregat

Isabel Fabregat

D-Index & Metrics

Biology and Biochemistry

D-Index
66
Citations
13374
World Ranking
8810
National Ranking
158

Overview

Isabel Fabregat is affiliated with the University of Barcelona in Spain and has an extensive publication record primarily focused on medicine and molecular biology. Their research intersects critical fields such as hepatology, oncology, immunology, and cancer research, contributing significant findings related to liver physiology, pathology, and disease mechanisms.

The scientist's work covers a broad spectrum of topics, including:

  • Liver physiology and pathology
  • Liver Disease Diagnosis and Treatment
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • TGF-β signaling in diseases
  • Nitric Oxide and Endothelin Effects
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Cancer, Hypoxia, and Metabolism

Fabregat has authored numerous papers, some of the recent noteworthy publications are:

  • The TGF-β Pathway: A Pharmacological Target in Hepatocellular Carcinoma? (2021), published in Cancers
  • Epithelial-Mesenchymal Transition (EMT) Induced by TGF-β in Hepatocellular Carcinoma Cells Reprograms Lipid Metabolism (2021), published in International Journal of Molecular Sciences
  • Mitochondrial bioenergetics boost macrophage activation, promoting liver regeneration in metabolically compromised animals (2021), published in Hepatology
  • The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression (2022), published in Hepatology
  • Proteoglycans in Cancer: Friends or Enemies? A Special Focus on Hepatocellular Carcinoma (2022), published in Cancers

Their work is frequently published in prominent venues with multiple contributions to the Journal of Hepatology, Free Radical Biology and Medicine, International Journal of Molecular Sciences, Cancers, and Cells.

Fabregat collaborates with several frequent coauthors, who contribute to the depth and scope of research. Key collaborators include:

  • Esther Bertrán
  • Ester Gonzalez-Sanchez
  • Javier Vaquero
  • Aranzazu Sánchez
  • Irene Peñuelas-Haro

The primary fields of study for Fabregat are Medicine and Biochemistry, Genetics and Molecular Biology. Their subfields concentrate on molecular biology processes, hepatology, oncology, immunology, and cancer research, reflecting a focused approach on liver diseases and associated molecular mechanisms.

Best Publications

  • Snail blocks the cell cycle and confers resistance to cell death

    Sonia Vega;Aixa V. Morales;Oscar H. Ocaña;Francisco Valdés

  • TGF-β signalling and liver disease.

    Isabel Fabregat;Joaquim Moreno‐Càceres;Aránzazu Sánchez;Steven Dooley

  • Reactive oxygen species (ROS) mediates the mitochondrial-dependent apoptosis induced by transforming growth factor (beta) in fetal hepatocytes.

    Blanca Herrera;Alberto. M. Álvarez;Aránzazu Sánchez;Margarita Fernández

  • Apoptosis induced by transforming growth factor-beta in fetal hepatocyte primary cultures: involvement of reactive oxygen intermediates.

    Aránzazu Sánchez;Alberto M. Álvarez;Manuel Benito;Isabel Fabregat

  • Dysregulation of apoptosis in hepatocellular carcinoma cells.

    Isabel Fabregat

  • European contribution to the study of ROS : a summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

    Javier Egea;Isabel Fabregat;Yves M Frapart;Pietro Ghezzi

  • Transforming Growth Factor-β-Induced Cell Plasticity in Liver Fibrosis and Hepatocarcinogenesis.

    Isabel Fabregat;Daniel Caballero-Díaz

  • The epithelial mesenchymal transition confers resistance to the apoptotic effects of transforming growth factor Beta in fetal rat hepatocytes.

    Francisco Valdés;Alberto M. Álvarez;Annamaria Locascio;Sonia Vega

  • Survival and apoptosis: a dysregulated balance in liver cancer.

    Isabel Fabregat;César Roncero;Margarita Fernández

  • TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer.

    Laia Caja;Francesco Dituri;Serena Mancarella;Daniel Caballero-Diaz

  • Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity.

    Irene Carmona-Cuenca;César Roncero;Patricia Sancho;Laia Caja

  • TGF-beta Signaling in Cancer Treatment

    Isabel Fabregat;Joan Fernando;Jessica Mainez;Patricia Sancho

  • Snail1 suppresses TGF-beta-induced apoptosis and is sufficient to trigger EMT in hepatocytes.

    D. Lorena Franco;Jèssica Mainez;Sonia Vega;Patricia Sancho

  • Molecular Mechanisms of Insulin Resistance in IRS-2-Deficient Hepatocytes

    Angela M Valverde;Deborah J Burks;Isabel Fabregat;Tracey L Fisher

  • NADPH Oxidase NOX4 Mediates Stellate Cell Activation and Hepatocyte Cell Death during Liver Fibrosis Development

    Patricia Sancho;Jèssica Mainez;Eva Crosas-Molist;César Roncero

  • Source of early reactive oxygen species in the apoptosis induced by transforming growth factor-β in fetal rat hepatocytes

    Blanca Herrera;Miguel M Murillo;Alberto Álvarez-Barrientos;Jesús Beltrán

  • Involvement of EGF receptor and c-Src in the survival signals induced by TGF-beta1 in hepatocytes.

    Miguel M Murillo;Gaelle del Castillo;Aránzazu Sánchez;Margarita Fernández

  • Role of NADPH oxidases in the redox biology of liver fibrosis

    Eva Crosas-Molist;Isabel Fabregat

  • New Insights into the Crossroads between EMT and Stemness in the Context of Cancer.

    Isabel Fabregat;Andrea Malfettone;Jitka Soukupova

  • TGF-β in Hepatic Stellate Cell Activation and Liver Fibrogenesis: Updated

    Bedair Dewidar;Bedair Dewidar;Jitka Soukupova;Isabel Fabregat;Steven Dooley

Frequent Co-Authors

Manuel Benito
Manuel Benito Complutense University of Madrid
Gianluigi Giannelli
Gianluigi Giannelli Gastroenterology Hospital "Saverio de Bellis"
Wolfgang Mikulits
Wolfgang Mikulits Medical University of Vienna
Ángela M. Valverde
Ángela M. Valverde Spanish National Research Council
Jorgina Satrústegui
Jorgina Satrústegui Spanish National Research Council
M. Angela Nieto
M. Angela Nieto Spanish National Research Council
Peter ten Dijke
Peter ten Dijke Leiden University Medical Center
Enrique Rozengurt
Enrique Rozengurt University of California, Los Angeles
Aristidis Moustakas
Aristidis Moustakas Uppsala University
Nelson Fausto
Nelson Fausto University of Washington

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