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D-Index & Metrics

Molecular Biology

D-Index
60
Citations
10775
World Ranking
1981
National Ranking
28

Overview

Manuel Benito is affiliated with Complutense University of Madrid in Spain. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on Molecular Biology, Epidemiology, Surgery, Geriatrics and Gerontology, and Cell Biology as subfields.

The main topics in Manuel Benito's research include pancreatic function and diabetes, autophagy in disease and therapy, sirtuins and resveratrol in medicine, endoplasmic reticulum stress and disease, extracellular vesicles in disease, bone metabolism and diseases, and bone tissue engineering materials.

Recent notable publications by Manuel Benito include:

  • Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease, 2021, Cells
  • Osteoporosis Remission and New Bone Formation with Mesoporous Silica Nanoparticles, 2021, Advanced Science
  • Dietary Polyphenols in Metabolic and Neurodegenerative Diseases: Molecular Targets in Autophagy and Biological Effects, 2021, Antioxidants
  • Human amylin aggregates release within exosomes as a protective mechanism in pancreatic β cells: Pancreatic β-hippocampal cell communication, 2021, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  • Biological Actions and Molecular Mechanisms of Sambucus nigra L. in Neurodegeneration: A Cell Culture Approach, 2021, Molecules

Frequent co-authors collaborating with Manuel Benito are:

  • Carlos González-Blanco
  • Patricia Marqués
  • Beatriz Jiménez
  • Carlos Guillén
  • Ana García-Aguilar

Manuel Benito has published regularly in several leading scientific journals. Frequent publication venues include:

  • Cells
  • Scientific Reports
  • Advanced Science
  • Antioxidants
  • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Their work contributes to multiple areas of medical and biological research, with particular attention to mechanisms of disease such as diabetes and neurodegeneration, as well as therapeutic approaches involving autophagy, extracellular vesicle communication, and bone tissue engineering materials.

Best Publications

  • Reactive oxygen species (ROS) mediates the mitochondrial-dependent apoptosis induced by transforming growth factor (beta) in fetal hepatocytes.

    Blanca Herrera;Alberto. M. Álvarez;Aránzazu Sánchez;Margarita Fernández

  • Apoptosis induced by transforming growth factor-beta in fetal hepatocyte primary cultures: involvement of reactive oxygen intermediates.

    Aránzazu Sánchez;Alberto M. Álvarez;Manuel Benito;Isabel Fabregat

  • p38α Mitogen-activated Protein Kinase Sensitizes Cells to Apoptosis Induced by Different Stimuli

    Almudena Porras;Susana Zuluaga;Emma Black;Amparo Valladares

  • The epithelial mesenchymal transition confers resistance to the apoptotic effects of transforming growth factor Beta in fetal rat hepatocytes.

    Francisco Valdés;Alberto M. Álvarez;Annamaria Locascio;Sonia Vega

  • β3-Adrenergic Stimulation Differentially Inhibits Insulin Signaling and Decreases Insulin-induced Glucose Uptake in Brown Adipocytes

    Johannes Klein;Mathias Fasshauer;Moriko Ito;Bradford B. Lowell

  • Essential Role of Insulin Receptor Substrate-2 in Insulin Stimulation of Glut4 Translocation and Glucose Uptake in Brown Adipocytes

    Mathias Fasshauer;Johannes Klein;Johannes Klein;Kohjiro Ueki;Kristina M. Kriauciunas

  • Essential Role of Insulin Receptor Substrate 1 in Differentiation of Brown Adipocytes

    Mathias Fasshauer;Mathias Fasshauer;Johannes Klein;Johannes Klein;Kristina M. Kriauciunas;Kohjiro Ueki

  • Differentiation of 3T3-L1 fibroblasts to adipocytes induced by transfection of ras oncogenes.

    Manuel Benito;Almudena Porras;Angel R. Nebreda;Eugenio Santos

  • Insulin produces myogenesis in C2C12 myoblasts by induction of NF-kappaB and downregulation of AP-1 activities.

    Ruben Conejo;Angela M. Valverde;Manuel Benito;Margarita Lorenzo

  • Molecular Mechanisms of Insulin Resistance in IRS-2-Deficient Hepatocytes

    Angela M Valverde;Deborah J Burks;Isabel Fabregat;Tracey L Fisher

  • IGF-I: A mitogen also involved in differentiation processes in mammalian cells

    Manuel Benito;Angela M. Valverde;Margarita Lorenzo

  • Cycloheximide prevents apoptosis, reactive oxygen species production, and glutathione depletion induced by transforming growth factor beta in fetal rat hepatocytes in primary culture.

    A Sanchez;A M Alvarez;M Benito;I Fabregat

  • Differential colorectal carcinogenesis: Molecular basis and clinical relevance

    Alberto Morán;Paloma Ortega;Carmen de Juan;Tamara Fernández-Marcelo

  • Rosiglitazone and retinoic acid induce uncoupling protein-1 (UCP-1) in a p38 mitogen-activated protein kinase-dependent manner in fetal primary brown adipocytes.

    Teresa Teruel;Rosario Hernandez;Manuel Benito;Margarita Lorenzo

  • Pancreatic β-Cell Failure Mediated by mTORC1 Hyperactivity and Autophagic Impairment

    Alberto Bartolomé;Maki Kimura-Koyanagi;Shun-Ichiro Asahara;Carlos Guillén

  • Autophagy Plays a Protective Role in Endoplasmic Reticulum Stress-Mediated Pancreatic β Cell Death

    Alberto Bartolome;Carlos Guillen;Manuel Benito

  • IGF-I is a mitogen involved in differentiation-related gene expression in fetal rat brown adipocytes.

    Margarita Lorenzo;Angela M. Valverde;Teresa Teruel;Manuel Benito

  • Telomere shortening is associated with poor prognosis and telomerase activity correlates with DNA repair impairment in non-small cell lung cancer

    Cristina Frías;Cristina García-Aranda;Carmen De Juan;Alberto Morán

  • Activation of caspases occurs downstream from radical oxygen species production, Bcl-xL down-regulation, and early cytochrome C release in apoptosis induced by transforming growth factor β in rat fetal hepatocytes

    Blanca Herrera;Margarita Fernández;Alberto M. Álvarez;César Roncero

  • Molecular biology in colorectal cancer.

    Manuel Benito;Eduardo Díaz-Rubio

Frequent Co-Authors

Ángela M. Valverde
Ángela M. Valverde Spanish National Research Council
Isabel Fabregat
Isabel Fabregat University of Barcelona
Antoni Torres
Antoni Torres University of Barcelona
C. Ronald Kahn
C. Ronald Kahn Harvard University
Loreto Daza
Loreto Daza Spanish National Research Council
Morris F. White
Morris F. White Boston Children's Hospital
Miguel de la Hoya
Miguel de la Hoya Hospital Clínico San Carlos
Eugenio Santos
Eugenio Santos University of Salamanca
Claes B. Wollheim
Claes B. Wollheim University of Geneva

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