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Biology and Biochemistry

D-Index
59
Citations
9130
World Ranking
12839
National Ranking
263

Overview

Jorgina Satrústegui is affiliated with the Spanish National Research Council in Spain. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with a significant focus on Neuroscience. Within these domains, their work covers subfields such as Molecular Biology, Cellular and Molecular Neuroscience, Clinical Biochemistry, Physiology, and Cell Biology.

The main topics addressed in their research include:

  • Mitochondrial Function and Pathology
  • Metabolism and Genetic Disorders
  • Neuroscience and Neuropharmacology Research
  • Hereditary Neurological Disorders
  • Genetic Neurodegenerative Diseases
  • Adipose Tissue and Metabolism
  • RNA modifications and cancer

Satrústegui has contributed to research published in a variety of scientific venues. The most frequent publication outlets include:

  • Journal of Neuroscience
  • IBJ Plus
  • IBRO Neuroscience Reports
  • Neurobiology of Disease
  • International Journal of Molecular Sciences

Notable recent papers authored or co-authored by Satrústegui are:

  • "A Ca2+-Dependent Mechanism Boosting Glycolysis and OXPHOS by Activating Aralar-Malate-Aspartate Shuttle, upon Neuronal Stimulation," 2022, Journal of Neuroscience
  • "Mitochondria and calcium defects correlate with axonal dysfunction in GDAP1-related Charcot-Marie-Tooth mouse model," 2021, Neurobiology of Disease
  • "βOHB Protective Pathways in Aralar-KO Neurons and Brain: An Alternative to Ketogenic Diet," 2020, Journal of Neuroscience
  • "AGC1 Deficiency: Pathology and Molecular and Cellular Mechanisms of the Disease," 2022, International Journal of Molecular Sciences
  • "Regulation of neuronal energy metabolism by calcium: Role of MCU and Aralar/malate-aspartate shuttle," 2023, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Frequent collaborators in their research include:

  • Beatriz Pardo
  • Araceli del Arco
  • Luis González-Moreno
  • Laura Contreras
  • Irene Pérez-Liébana

Best Publications

  • Citrin and aralar1 are Ca2+‐stimulated aspartate/glutamate transporters in mitochondria

    Luigi Palmieri;B. Pardo;F. M. Lasorsa;A. Del Arco;A. Del Arco

  • Lithium protects cultured neurons against β-amyloid-induced neurodegeneration

    Gema Alvarez;Juan Ramón Muñoz-Montaño;Jorgina Satrústegui;Jesús Avila

  • Mitochondrial transporters as novel targets for intracellular calcium signaling

    Jorgina Satrústegui;Beatriz Pardo;Araceli del Arco

  • Molecular Cloning of Aralar, a New Member of the Mitochondrial Carrier Superfamily That Binds Calcium and Is Present in Human Muscle and Brain

    Araceli del Arco;Jorgina Satrústegui

  • Whole-Exome Sequencing Identifies MDH2 as a New Familial Paraganglioma Gene

    Alberto Cascón;Iñaki Comino-Méndez;María Currás-Freixes;Aguirre A. de Cubas

  • Reduced N-acetylaspartate levels in mice lacking aralar, a brain- and muscle-type mitochondrial aspartate-glutamate carrier.

    Md. Abdul Jalil;Laila Begum;Laura Contreras;Beatriz Pardo

  • The regulation of neuronal mitochondrial metabolism by calcium

    I. Llorente-Folch;I. Llorente-Folch;C. B. Rueda;C. B. Rueda;B. Pardo;B. Pardo;G. Szabadkai;G. Szabadkai

  • Developmental changes in the Ca2+-regulated mitochondrial aspartate–glutamate carrier aralar1 in brain and prominent expression in the spinal cord

    Milagros Ramos;Araceli del Arco;Araceli del Arco;Beatriz Pardo;Alberto Martı́nez-Serrano

  • Identification of a novel human subfamily of mitochondrial carriers with calcium-binding domains.

    Araceli del Arco;Araceli del Arco;Jorgina Satrústegui

  • Regulation of tau phosphorylation and protection against β-amyloid-induced neurodegeneration by lithium. Possible implications for Alzheimer's disease

    Gema Alvarez;Juan Ramón Muñoz-Montaño;Jorgina Satrústegui;Jesús Avila

  • The Malate-Aspartate NADH Shuttle Member Aralar1 Determines Glucose Metabolic Fate, Mitochondrial Activity, and Insulin Secretion in Beta Cells *

    Blanca Rubi;Araceli del Arco;Clarissa Bartley;Jorgina Satrustegui

  • Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases

    Niamh M.C. Connolly;Pierre Theurey;Vera Adam-Vizi;Nicolas G. Bazan

  • Postnatal development of rat liver mitochondrial functions. The roles of protein synthesis and of adenine nucleotides.

    C Valcarce;R M Navarrete;P Encabo;E Loeches

  • Calcium binding to the cytosol and calcium extrusion mechanisms in intact synaptosomes and their alterations with aging.

    A Martinez-Serrano;P Blanco;J Satrústegui

  • Essential Role of Aralar in the Transduction of Small Ca+ Signals to Neuronal Mitochondria

    Beatriz Pardo;Laura Contreras;Antonio Serrano;Milagros Ramos

  • Calcium Signaling in Brain Mitochondria INTERPLAY OF MALATE ASPARTATE NADH SHUTTLE AND CALCIUM UNIPORTER/MITOCHONDRIAL DEHYDROGENASE PATHWAYS

    Laura Contreras;Jorgina Satrústegui

  • Identification and metabolic role of the mitochondrial aspartate-glutamate transporter in Saccharomyces cerevisiae.

    S. Cavero;A. Vozza;A. Del Arco;A. Del Arco;L. Palmieri

  • Ca2+ Activation Kinetics of the Two Aspartate-Glutamate Mitochondrial Carriers, Aralar and Citrin ROLE IN THE HEART MALATE-ASPARTATE NADH SHUTTLE

    Laura Contreras;Paulino Gomez-Puertas;Mikio Iijima;Keiko Kobayashi

  • New mitochondrial carriers: an overview.

    A. del Arco;J. Satrústegui

  • Calcium-Regulation of Mitochondrial Respiration Maintains ATP Homeostasis and Requires ARALAR/AGC1-Malate Aspartate Shuttle in Intact Cortical Neurons

    Irene Llorente-Folch;Carlos B. Rueda;Ignacio Amigo;Araceli del Arco

Frequent Co-Authors

Javier Vitorica
Javier Vitorica University of Seville
Paulino Gómez-Puertas
Paulino Gómez-Puertas Spanish National Research Council
Isabel Fabregat
Isabel Fabregat University of Barcelona
James B. Hurley
James B. Hurley University of Washington
Michael R. Duchen
Michael R. Duchen University College London
José M. Cuezva
José M. Cuezva Autonomous University of Madrid
Martin Sadilek
Martin Sadilek University of Washington
Gyorgy Szabadkai
Gyorgy Szabadkai University College London
Manel Esteller
Manel Esteller Josep Carreras Leukaemia Research Institute

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