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Biology and Biochemistry

D-Index
84
Citations
29888
World Ranking
3276
National Ranking
1661

Overview

James B. Hurley is affiliated with the University of Washington in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, Medicine, and Neuroscience. Within these broad disciplines, their subfields of study include Molecular Biology, Ophthalmology, Cellular and Molecular Neuroscience, Neurology, and Radiology, Nuclear Medicine and Imaging.

The scientist's main topics of work focus on areas related to the retina and neurobiology. These topics include Retinal Development and Disorders, Retinal Diseases and Treatments, Photoreceptor and Optogenetics Research, Neuroinflammation and Neurodegeneration Mechanisms, Mitochondrial Function and Pathology, 3D Printing in Biomedical Research, and Retinal Imaging and Analysis.

Hurley's publication record includes several recent papers that reflect focus on retinal and mitochondrial biology. Notable papers are:

  • Retina Metabolism and Metabolism in the Pigmented Epithelium: A Busy Intersection, 2021, Annual Review of Vision Science
  • Succinate Can Shuttle Reducing Power from the Hypoxic Retina to the O2-Rich Pigment Epithelium, 2020, Cell Reports
  • The Multi-Tissue Landscape of Somatic mtDNA Mutations Indicates Tissue-Specific Accumulation and Removal in Aging, 2023, eLife
  • Daily Mitochondrial Dynamics in Cone Photoreceptors, 2020, Proceedings of the National Academy of Sciences
  • Succinate Metabolism in the Retinal Pigment Epithelium Uncouples Respiration from ATP Synthesis, 2022, Cell Reports

Hurley often collaborates with several coauthors, including Daniel T. Hass, Brian M. Robbings, Ian R. Sweet, Celia M. Bisbach, and Jennifer R. Chao. These frequent collaborators indicate active engagement in multidisciplinary and collaborative research environments.

The scientist has published research in a range of venues, with the most frequent including bioRxiv (Cold Spring Harbor Laboratory), Investigative Ophthalmology & Visual Science, Journal of Biological Chemistry, SSRN Electronic Journal, and Cell Reports. Their contributions to these journals demonstrate involvement in both preprint and peer-reviewed literature, spanning molecular and vision science.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Flow of information in the light-triggered cyclic nucleotide cascade of vision.

    Bernard K. K. Fung;James B. Hurley;Lubert Stryer

  • Distribution and morphology of human cone photoreceptors stained with anti-blue opsin.

    Christine A. Curcio;Kimberly A. Allen;Kenneth R. Sloan;Connie L. Lerea

  • Recoverin: a calcium sensitive activator of retinal rod guanylate cyclase.

    Alexander M. Dizhoor;Sanghamitra Ray;Santosh Kumar;Greg Niemi

  • A thyroid hormone receptor that is required for the development of green cone photoreceptors.

    Lily Ng;James B. Hurley;Blair Dierks;Maya Srinivas

  • Homologies between signal transducing G proteins and ras gene products

    James B. Hurley;Melvin I. Simon;David B. Teplow;Janet D. Robishaw

  • Repetitive Segmental Structure of the Transducin β Subunit: Homology with the CDC4 Gene and Identification of Related mRNAs

    Henry K. W. Fong;James B. Hurley;Rosemary S. Hopkins;Ryn Miake-Lye

  • A behavioral screen for isolating zebrafish mutants with visual system defects

    Susan E. Brockerhoff;James B. Hurley;Ulrike Janssen-Bienhold;Stephan C. F. Neuhauss

  • The human photoreceptor membrane guanylyl cyclase, RetGC, is present in outer segments and is regulated by calcium and a soluble activator

    Alexander M. Dizhoor;David G. Lowe;Elena V. Olshevskaya;Richard P. Laura

  • Purification and characterization of the gamma regulatory subunit of the cyclic GMP phosphodiesterase from retinal rod outer segments.

    J B Hurley;L Stryer

  • Cloning, Sequencing, and Expression of a 24-kDa Ca2+-binding Protein Activating Photoreceptor Guanylyl Cyclase

    Alexander M. Dizhoor;Elena V. Olshevskaya;William J. Henzel;Susan C. Wong

  • Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase

    Ching Kang Chen;Marie E. Burns;Maribeth Spencer;Gregory A. Niemi

  • Transduction mechanisms of vertebrate and invertebrate photoreceptors.

    Stuart Yarfitz;James B. Hurley

  • Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye

    Mark A Kanow;Michelle M Giarmarco;Connor Sr Jankowski;Kristine Tsantilas

  • Ca2+-dependent Interaction of Recoverin with Rhodopsin Kinase *

    Ching Kang Chen;James Inglese;Robert J. Lefkowitz;James B. Hurley

  • Identification of Specific Transducin α Subunits in Retinal Rod and Cone Photoreceptors

    Connie L. Lerea;David E. Somers;James B. Hurley;Ingrid B. Klock

  • Cloning and expression of a second photoreceptor-specific membrane retina guanylyl cyclase (RetGC), RetGC-2

    David G. Lowe;Alexander M. Dizhoor;Kathleen Liu;Qimin Gu

  • Polyglutamine-expanded ataxin-7 antagonizes CRX function and induces cone-rod dystrophy in a mouse model of SCA7.

    Albert R. La Spada;Ying Hui Fu;Bryce L. Sopher;Randell T. Libby

  • Role of the Acylated Amino Terminus of Recoverin in Ca 2+ -Dependent Membrane Interaction

    Alexander M. Dizhoor;Ching Kang Chen;Elena Olshevskaya;Valeria V. Sinelnikova

  • Visual cycle impairment in cellular retinaldehyde binding protein (CRALBP) knockout mice results in delayed dark adaptation.

    John C. Saari;Maria Nawrot;Breandan N. Kennedy;Gregory G. Garwin

Frequent Co-Authors

Martin Sadilek
Martin Sadilek University of Washington
Alexander M. Dizhoor
Alexander M. Dizhoor Salus University
Lubert Stryer
Lubert Stryer Stanford University
Vsevolod V. Gurevich
Vsevolod V. Gurevich Vanderbilt University
Daniel Raftery
Daniel Raftery University of Washington
Melvin I. Simon
Melvin I. Simon California Institute of Technology
Jorgina Satrústegui
Jorgina Satrústegui Spanish National Research Council
Kenneth A. Walsh
Kenneth A. Walsh University of Washington
John E. Dowling
John E. Dowling Harvard University
Albert R. La Spada
Albert R. La Spada University of California, Irvine

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