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Microbiology

D-Index
49
Citations
8471
World Ranking
4577
National Ranking
1768

Overview

Niranjan Y. Sardesai is affiliated with the University of Pennsylvania in the United States and has contributed extensively to the fields of medicine, immunology, and molecular biology. Their research spans multiple subfields including oncology, immunology, molecular biology, biotechnology, and hepatology, reflecting a diversified interest in biomedical sciences.

Their work primarily focuses on areas such as immunotherapy and immune responses, cancer immunotherapy and biomarkers, CAR-T cell therapy research, vaccines and immunoinformatics approaches, hepatocellular carcinoma treatment and prognosis, transgenic plants and applications, as well as RNA interference and gene delivery.

Frequent coauthors collaborating with the scientist include:

  • Neil Cooch
  • Alfredo Perales-Puchalt
  • Mark Yarchoan
  • Sarah Rochestie
  • David B. Weiner

Their publications have appeared in several scientific venues, with notable repeated contributions to:

  • Regular and Young Investigator Award Abstracts
  • Cancer Research
  • Journal of Clinical Oncology
  • Vaccine Insights
  • Nature Medicine

Some recent published papers by Niranjan Y. Sardesai include:

  • Personalized neoantigen vaccine and pembrolizumab in advanced hepatocellular carcinoma: a phase 1/2 trial, 2024, Nature Medicine
  • Robust antibody and cellular responses induced by DNA-only vaccination for HIV, 2020, JCI Insight
  • Intramuscular and Intradermal Electroporation of HIV-1 PENNVAX-GP® DNA Vaccine and IL-12 Is Safe, Tolerable, Acceptable in Healthy Adults, 2020, Vaccines
  • A synDNA vaccine delivering neoAg collections controls heterogenous, multifocal murine lung and ovarian tumors via robust T cell generation, 2021, Molecular Therapy - Oncolytics
  • Personalized Neoantigen Vaccine and Pembrolizumab in Advanced Hepatocellular Carcinoma: A phase 1/2 trial, 2024, immuneACCESS

Best Publications

  • Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, placebo-controlled phase 2b trial.

    Cornelia L Trimble;Matthew P Morrow;Kimberly A Kraynyak;Xuefei Shen

  • Electroporation delivery of DNA vaccines: prospects for success

    Niranjan Y Sardesai;David B Weiner

  • Immunotherapy Against HPV16/18 Generates Potent TH1 and Cytotoxic Cellular Immune Responses

    Mark L. Bagarazzi;Jian Yan;Matthew P. Morrow;Xuefei Shen

  • A synthetic consensus anti–spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primates

    Karuppiah Muthumani;Darryl Falzarano;Emma L. Reuschel;Colleen Tingey

  • Safety and Comparative Immunogenicity of an HIV-1 DNA Vaccine in Combination with Plasmid Interleukin 12 and Impact of Intramuscular Electroporation for Delivery

    Spyros A. Kalams;Scott D. Parker;Marnie Elizaga;Barbara Metch

  • Immunogenicity of novel consensus-based DNA vaccines against Chikungunya virus.

    Karuppiah Muthumani;Katthikbabu M. Lankaraman;Dominick J. Laddy;Senthil G. Sundaram;Senthil G. Sundaram

  • A DNA vaccine against chikungunya virus is protective in mice and induces neutralizing antibodies in mice and nonhuman primates.

    Karthik Mallilankaraman;Devon J. Shedlock;Huihui Bao;Omkar U. Kawalekar

  • MESOMARK™: A Potential Test for Malignant Pleural Mesothelioma

    Heather L. Beyer;Ryan D. Geschwindt;Curtis L. Glover;Ly Tran

  • Heterosubtypic Protection against Pathogenic Human and Avian Influenza Viruses via In Vivo Electroporation of Synthetic Consensus DNA Antigens

    Dominick J. Laddy;Jian Yan;Michele Kutzler;Darwyn Kobasa

  • Personalized neoantigen vaccine and pembrolizumab in advanced hepatocellular carcinoma: a phase 1/2 trial

    Unknown

  • Mesothelin Variant 1 Is Released from Tumor Cells as a Diagnostic Marker

    Ingegerd Hellstrom;John Raycraft;Sandra Kanan;Niranjan Y. Sardesai

  • In vivo protection against ZIKV infection and pathogenesis through passive antibody transfer and active immunisation with a prMEnv DNA vaccine

    Karuppiah Muthumani;Bryan D Griffin;Bryan D Griffin;Sangya Agarwal;Sagar B Kudchodkar

  • Intradermal SynCon® Ebola GP DNA Vaccine Is Temperature Stable and Safely Demonstrates Cellular and Humoral Immunogenicity Advantages in Healthy Volunteers

    Pablo Tebas;Kimberly A Kraynyak;Ami Patel;Joel N Maslow

  • Multivalent Smallpox DNA Vaccine Delivered by Intradermal Electroporation Drives Protective Immunity in Nonhuman Primates Against Lethal Monkeypox Challenge

    Lauren A. Hirao;Ruxandra Draghia-Akli;Jonathan T. Prigge;Maria Yang

  • Development of a novel DNA SynCon tetravalent dengue vaccine that elicits immune responses against four serotypes.

    Mathura P. Ramanathan;Yuan-Chia Kuo;Bernard H. Selling;Qianjun Li

  • Tolerability of intramuscular and intradermal delivery by CELLECTRA(®) adaptive constant current electroporation device in healthy volunteers.

    Malissa C Diehl;Jessica C Lee;Stephen E Daniels;Pablo Tebas

  • DNA Recognition by Peptide Complexes of Rhodium(III): Example of a Glutamate Switch

    Niranjan Y. Sardesai;Kaspar Zimmermann;Jacqueline K. Barton

  • The p40 Subunit of Interleukin (IL)-12 Promotes Stabilization and Export of the p35 Subunit IMPLICATIONS FOR IMPROVED IL-12 CYTOKINE PRODUCTION

    Rashmi Jalah;Margherita Rosati;Brunda Ganneru;Guy R. Pilkington

  • A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques

    Beatriz Mothe;Xintao Hu;Anuska Llano;Margherita Rosati

  • DNA vaccination protects mice against Zika virus-induced damage to the testes.

    Bryan D. Griffin;Bryan D. Griffin;Kar Muthumani;Bryce M. Warner;Bryce M. Warner;Anna Majer

  • Immunogenicity of Novel Consensus-Based DNA Vaccines Against Chikungunya Virus

    K. Muthumani;K. Lankaraman;D. Laddy;S. Sundaram

Frequent Co-Authors

David B. Weiner
David B. Weiner The Wistar Institute
Karuppiah Muthumani
Karuppiah Muthumani The Wistar Institute
Barbara K. Felber
Barbara K. Felber National Institutes of Health
George N. Pavlakis
George N. Pavlakis Emory University
Jean D. Boyer
Jean D. Boyer Inovio Pharmaceuticals (United States)
David C. Montefiori
David C. Montefiori Duke University
Gary Kobinger
Gary Kobinger The University of Texas Medical Branch at Galveston
James I. Mullins
James I. Mullins University of Washington
Kenneth E. Ugen
Kenneth E. Ugen University of South Florida
Celia C. LaBranche
Celia C. LaBranche Duke University

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