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Medicine

D-Index
85
Citations
25576
World Ranking
14647
National Ranking
7411

Overview

Andrew Holmes is affiliated with the National Institutes of Health in the United States and has contributed extensively to neuroscience research. Their primary field of study is Neuroscience, with 36 publications, focusing particularly on the subfields of Cognitive Neuroscience, Cellular and Molecular Neuroscience, Social Psychology, Molecular Biology, and Behavioral Neuroscience.

The topics central to Holmes's research include Memory and Neural Mechanisms, Neuroscience and Neuropharmacology Research, Neuroendocrine regulation and behavior, Neurotransmitter Receptor Influence on Behavior, Stress Responses and Cortisol, Neural dynamics and brain function, and Alcohol Consumption and Health Effects.

Holmes's recent publications include the following papers:

  • "Amygdala Circuit Substrates for Stress Adaptation and Adversity", 2021, Biological Psychiatry
  • "Intercalated amygdala clusters orchestrate a switch in fear state", 2021, Nature
  • "Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice", 2020, Nature Chemical Biology
  • "Central amygdala micro-circuits mediate fear extinction", 2021, Nature Communications
  • "Sex Differences in the Brain Transcriptome Related to Alcohol Effects and Alcohol Use Disorder", 2021, Biological Psychiatry

Holmes frequently publishes in several prominent venues, including Biological Psychiatry with three publications, Nature with two, Nature Chemical Biology, Nature Communications, and Neuropharmacology.

The scientist collaborates regularly with several coauthors, including:

  • Olena Bukalo (4 collaborations)
  • Elissa J. Chesler (4 collaborations)
  • Aaron Limoges (3 collaborations)
  • Andreas Lüthi (3 collaborations)
  • Ozge Gunduz-Cinar (3 collaborations)

Holmes's work spans numerous topics related to brain function and behavior, with attention to the neural mechanisms of memory, stress adaptation, fear states, emotional behavior modulation, and the effects of alcohol on brain transcriptomes.

Best Publications

  • Genetic Sensitivity to the Environment: The Case of the Serotonin Transporter Gene and Its Implications for Studying Complex Diseases and Traits

    Avshalom Caspi;Ahmad R Hariri;Andrew Bruce Holmes;Rudolf Uher

  • Genetics of emotional regulation: the role of the serotonin transporter in neural function

    Ahmad R. Hariri;Andrew Holmes

  • Animal models of anxiety: an ethological perspective

    R.J. Rodgers;B.-J. Cao;A. Dalvi;A. Holmes

  • The neural basis of reversal learning: An updated perspective.

    Alicia Izquierdo;Jonathan L. Brigman;Anna K. Radke;Peter H. Rudebeck

  • Stress-induced prefrontal reorganization and executive dysfunction in rodents

    Andrew Holmes;Cara L. Wellman

  • Brief uncontrollable stress causes dendritic retraction in infralimbic cortex and resistance to fear extinction in mice.

    Alicia Izquierdo;Cara L. Wellman;Andrew Holmes

  • Neuropeptide systems as novel therapeutic targets for depression and anxiety disorders

    Andrew Holmes;Markus Heilig;Nadia M.J. Rupniak;Thomas Steckler

  • Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala

    Catherine A. Marcinkiewcz;Christopher M. Mazzone;Giuseppe D’Agostino;Lindsay R. Halladay

  • The touchscreen operant platform for testing learning and memory in rats and mice

    Alexa E Horner;Christopher J Heath;Martha Hvoslef-Eide;Brianne A Kent

  • Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders.

    N. Singewald;C. Schmuckermair;N. Whittle;A. Holmes

  • Effects of repeated maternal separation on anxiety- and depression-related phenotypes in different mouse strains.

    Rachel A. Millstein;Andrew Holmes

  • Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression.

    Andrew Holmes;Dennis L Murphy;Jacqueline N Crawley

  • Impaired Stress-Coping and Fear Extinction and Abnormal Corticolimbic Morphology in Serotonin Transporter Knock-Out Mice

    C. L. Wellman;A. Izquierdo;J. E. Garrett;K. P. Martin

  • 50 years of hurdles and hope in anxiolytic drug discovery.

    Guy Griebel;Andrew Holmes

  • Loss of GluN2B-Containing NMDA Receptors in CA1 Hippocampus and Cortex Impairs Long-Term Depression, Reduces Dendritic Spine Density, and Disrupts Learning

    Jonathan L. Brigman;Tara Wright;Giuseppe Talani;Shweta Prasad-Mulcare

  • Stress and Fear Extinction.

    Stephen Maren;Andrew Holmes

  • Mice lacking the serotonin transporter exhibit 5-HT(1A) receptor-mediated abnormalities in tests for anxiety-like behavior.

    Andrew Holmes;Rebecca J Yang;Klaus-Peter Lesch;Jacqueline N Crawley

  • Abnormal anxiety-related behavior in serotonin transporter null mutant mice: the influence of genetic background

    A. Holmes;Q. Li;D. L. Murphy;E. Gold

  • Early life genetic, epigenetic and environmental factors shaping emotionality in rodents.

    Andrew Holmes;Anne Marie le Guisquet;Elise Vogel;Rachel A. Millstein

  • Evaluation of antidepressant-related behavioral responses in mice lacking the serotonin transporter.

    Andrew Holmes;Rebecca J Yang;Dennis L Murphy;Jacqueline N Crawley

Frequent Co-Authors

Lisa M. Saksida
Lisa M. Saksida University of Western Ontario
Timothy J. Bussey
Timothy J. Bussey University of Western Ontario
Jacqueline N. Crawley
Jacqueline N. Crawley University of California, Davis
Nicolas Singewald
Nicolas Singewald University of Innsbruck
Dennis L. Murphy
Dennis L. Murphy National Institutes of Health
Ahmad R. Hariri
Ahmad R. Hariri Duke University
Markus Heilig
Markus Heilig Linköping University
Cara L. Wellman
Cara L. Wellman Indiana University
Thomas L. Kash
Thomas L. Kash University of North Carolina at Chapel Hill
Robert W. Williams
Robert W. Williams University of Tennessee Health Science Center

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