The scientist’s investigation covers issues in Neuroscience, DNA methylation, Endocrinology, Internal medicine and Microglia. His biological study spans a wide range of topics, including Serotonergic and Programmed cell death. His Serotonergic research includes elements of Neurogenesis, Chronic stress, Hippocampal formation and Anhedonia.
His work deals with themes such as Methylation and Epigenetics, which intersect with DNA methylation. The Microglia study which covers Neuroinflammation that intersects with Anterior cingulate cortex, Cingulate cortex, Age of onset and Dementia. Naguib Mechawar combines subjects such as Major depressive disorder, Microarray, Hippocampus and GABAergic with his study of Prefrontal cortex.
His primary scientific interests are in Neuroscience, Internal medicine, Endocrinology, Hippocampus and DNA methylation. Hippocampal formation, Prefrontal cortex, Neurogenesis, Dentate gyrus and Anterior cingulate cortex are the primary areas of interest in his Neuroscience study. His research integrates issues of Cerebellum, Transcriptome and Major depressive disorder in his study of Prefrontal cortex.
Naguib Mechawar works mostly in the field of Anterior cingulate cortex, limiting it down to topics relating to Gap junction and, in certain cases, Astrocyte, as a part of the same area of interest. Endocrinology is closely attributed to Receptor in his work. Within one scientific family, Naguib Mechawar focuses on topics pertaining to Methylation under DNA methylation, and may sometimes address concerns connected to Promoter.
Neuroscience, Astrocyte, Depression, DNA methylation and Internal medicine are his primary areas of study. His work on Major depressive disorder, Prefrontal cortex and Human brain as part of his general Neuroscience study is frequently connected to Confocal, thereby bridging the divide between different branches of science. Naguib Mechawar interconnects Glial fibrillary acidic protein, Anterior cingulate cortex, Vimentin, Cell type and Gap junction in the investigation of issues within Astrocyte.
In his work, Social stress and Mood disorders is strongly intertwined with Blood–brain barrier, which is a subfield of Depression. The study incorporates disciplines such as Chromatin, Methylation and Epigenetics in addition to DNA methylation. His Internal medicine research incorporates themes from Endocrinology, Oncology and Neuropsychology.
The scientist’s investigation covers issues in Internal medicine, Cell type, Endocrinology, Neuroscience and Major depressive disorder. His Internal medicine research includes themes of Neuroimaging, Oncology and Neuropsychology. His work carried out in the field of Cell type brings together such families of science as Astrocyte and Animal models of depression.
In his study, Gene expression, Mood disorders and Downregulation and upregulation is inextricably linked to Gap junction, which falls within the broad field of Astrocyte. His Neuroscience study frequently draws connections between adjacent fields such as Synaptic plasticity. His study in Major depressive disorder is interdisciplinary in nature, drawing from both Transcriptome, Putamen and Tyrosine hydroxylase.
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Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects
Ian Mahar;Ian Mahar;Francis Rodriguez Bambico;Naguib Mechawar;José N. Nobrega.
Neuroscience & Biobehavioral Reviews (2014)
Genome-wide Epigenetic Regulation by Early-Life Trauma
Benoit Labonté;Matt Suderman;Gilles Maussion;Luis Navaro.
Archives of General Psychiatry (2012)
Sex-specific transcriptional signatures in human depression.
Benoit Labonté;Olivia Engmann;Immanuel Purushothaman;Caroline Menard.
Nature Medicine (2017)
Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides
Susana G. Torres-Platas;Cristiana Cruceanu;Gary Gang Chen;Gustavo Turecki.
Brain Behavior and Immunity (2014)
Global brain gene expression analysis links glutamatergic and GABAergic alterations to suicide and major depression.
Adolfo Sequeira;Firoza Mamdani;Carl Ernst;Marquis P. Vawter.
PLOS ONE (2009)
Differential glucocorticoid receptor exon 1(B), 1(C), and 1(H) expression and methylation in suicide completers with a history of childhood abuse.
Benoit Labonte;Benoit Labonte;Volodymyr Yerko;Jeffrey Gross;Jeffrey Gross;Naguib Mechawar;Naguib Mechawar.
Biological Psychiatry (2012)
Postmortem evidence of cerebral inflammation in schizophrenia: a systematic review
M O Trépanier;K E Hopperton;R Mizrahi;N Mechawar.
Molecular Psychiatry (2016)
The neurodevelopmental origins of suicidal behavior
Gustavo Turecki;Carl Ernst;Fabrice Jollant;Benoit Labonté.
Trends in Neurosciences (2012)
miR-1202 is a primate-specific and brain-enriched microRNA involved in major depression and antidepressant treatment.
Juan Pablo Lopez;Raymond Lim;Cristiana Cruceanu;Liam Crapper.
Nature Medicine (2014)
Ultrastructural evidence for diffuse transmission by monoamine and acetylcholine neurons of the central nervous system
Laurent Descarries;Naguib Mechawar.
Progress in Brain Research (2000)
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