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Naguib Mechawar

Naguib Mechawar

D-Index & Metrics

Neuroscience

D-Index
68
Citations
15925
World Ranking
2759
National Ranking
157

Overview

Naguib Mechawar is affiliated with McGill University in Canada and has contributed extensively to the field of neuroscience. Their research primarily spans the areas of Neuroscience and Biochemistry, Genetics and Molecular Biology. Within these fields, Mechawar has focused notably on specialties such as Molecular Biology, Neurology, Cellular and Molecular Neuroscience, Biological Psychiatry, and Behavioral Neuroscience.

The scientist's work covers various main topics including:

  • Neuroinflammation and Neurodegeneration Mechanisms
  • Tryptophan and brain disorders
  • Stress Responses and Cortisol
  • Neuroscience and Neuropharmacology Research
  • Epigenetics and DNA Methylation
  • Neurogenesis and neuroplasticity mechanisms
  • Single-cell and spatial transcriptomics

Mechawar has a strong publication record with frequent contributions to venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Psychiatry
  • Biological Psychiatry
  • Translational Psychiatry
  • Frontiers in Psychiatry

Some notable recent papers authored or co-authored by Mechawar include:

  • Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons (2020) - Nature Neuroscience
  • Molecular adaptations of the blood-brain barrier promote stress resilience vs. depression (2020) - Proceedings of the National Academy of Sciences
  • Implication of cerebral astrocytes in major depression: A review of fine neuroanatomical evidence in humans (2021) - Glia
  • Cell type specific transcriptomic differences in depression show similar patterns between males and females but implicate distinct cell types and genes (2023) - Nature Communications
  • Neuron-derived extracellular vesicles enriched from plasma show altered size and miRNA cargo as a function of antidepressant drug response (2021) - Molecular Psychiatry

Mechawar frequently collaborates with other researchers. Co-authors with whom they have worked extensively include Gustavo Turecki, Corina Nagy, Maria Antonietta Davoli, Reza Rahimian, and Claudia Belliveau.

Best Publications

  • Sex-specific transcriptional signatures in human depression.

    Benoit Labonté;Olivia Engmann;Immanuel Purushothaman;Caroline Menard

  • Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects

    Ian Mahar;Ian Mahar;Francis Rodriguez Bambico;Naguib Mechawar;José N. Nobrega

  • Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides

    Susana G. Torres-Platas;Cristiana Cruceanu;Gary Gang Chen;Gustavo Turecki

  • Genome-wide Epigenetic Regulation by Early-Life Trauma

    Benoit Labonté;Matt Suderman;Gilles Maussion;Luis Navaro

  • Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons.

    Corina Nagy;Malosree Maitra;Arnaud Tanti;Matthew Suderman

  • Global brain gene expression analysis links glutamatergic and GABAergic alterations to suicide and major depression.

    Adolfo Sequeira;Firoza Mamdani;Carl Ernst;Marquis P. Vawter

  • Postmortem evidence of cerebral inflammation in schizophrenia: a systematic review

    M O Trépanier;K E Hopperton;R Mizrahi;N Mechawar

  • Differential glucocorticoid receptor exon 1(B), 1(C), and 1(H) expression and methylation in suicide completers with a history of childhood abuse.

    Benoit Labonte;Benoit Labonte;Volodymyr Yerko;Jeffrey Gross;Jeffrey Gross;Naguib Mechawar;Naguib Mechawar

  • Morphometric characterization of microglial phenotypes in human cerebral cortex

    Susana G Torres-Platas;Susana G Torres-Platas;Samuel Comeau;Samuel Comeau;Adeline Rachalski;Adeline Rachalski;Gregory Dal Bo;Gregory Dal Bo

  • miR-1202 is a primate-specific and brain-enriched microRNA involved in major depression and antidepressant treatment.

    Juan Pablo Lopez;Raymond Lim;Cristiana Cruceanu;Liam Crapper

  • Molecular adaptations of the blood–brain barrier promote stress resilience vs. depression

    Katarzyna A. Dudek;Laurence Dion-Albert;Manon Lebel;Katherine LeClair

  • The neurodevelopmental origins of suicidal behavior

    Gustavo Turecki;Carl Ernst;Fabrice Jollant;Benoit Labonté

  • Astrocytic abnormalities and global DNA methylation patterns in depression and suicide.

    Corina Nagy;Matthew Suderman;Jennie Yang;Moshe Szyf

  • Ultrastructural evidence for diffuse transmission by monoamine and acetylcholine neurons of the central nervous system

    Laurent Descarries;Naguib Mechawar

  • Evaluating the suitability of nicotinic acetylcholine receptor antibodies for standard immunodetection procedures

    N. Moser;N. Mechawar;I. Jones;A. Gochberg-Sarver

  • Astrocytic hypertrophy in anterior cingulate white matter of depressed suicides.

    Susana G Torres-Platas;Christa Hercher;Maria Antonietta Davoli;Gilles Maussion

  • Apoptosis-inducing factor: a matter of neuron life and death.

    Slavica Krantic;Naguib Mechawar;Stéphanie Reix;Stéphanie Reix;Rémi Quirion

  • Molecular basis of programmed cell death involved in neurodegeneration

    Slavica Krantic;Naguib Mechawar;Stéphanie Reix;Stéphanie Reix;Rémi Quirion

  • MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes.

    Juan Pablo Lopez;Laura M. Fiori;Cristiana Cruceanu;Rixing Lin

  • Genome-Wide Methylation Changes in the Brains of Suicide Completers

    Benoit Labonté;Matt Suderman;Gilles Maussion;Juan Pablo Lopez

Frequent Co-Authors

Bruno Giros
Bruno Giros McGill University
Pedro Rosa-Neto
Pedro Rosa-Neto McGill University
Laurent Descarries
Laurent Descarries University of Montreal
Scott J. Russo
Scott J. Russo Icahn School of Medicine at Mount Sinai
Eric J. Nestler
Eric J. Nestler Icahn School of Medicine at Mount Sinai
Jean-Paul Soucy
Jean-Paul Soucy Montreal Neurological Institute and Hospital
Salah El Mestikawy
Salah El Mestikawy Douglas Mental Health University Institute
Jonathan Mill
Jonathan Mill University of Exeter
Sam A. Golden
Sam A. Golden University of Washington
Erin S. Calipari
Erin S. Calipari Vanderbilt University

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