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D-Index & Metrics

Biology and Biochemistry

D-Index
61
Citations
14823
World Ranking
11265
National Ranking
866

Overview

Leo C. James is affiliated with the MRC Laboratory of Molecular Biology in the United Kingdom. Their research spans multiple fields with a particular focus on Medicine and Biochemistry, Genetics, and Molecular Biology. Their work addresses a variety of subfields including Infectious Diseases, Molecular Biology, Immunology, Virology, and Neurology.

Their research topics notably cover areas such as SARS-CoV-2 and COVID-19 Research, HIV Research and Treatment, interferon and immune responses, Bacteriophages and microbial interactions, SARS-CoV-2 detection and testing, Neuroinflammation and Neurodegeneration Mechanisms, and Animal Virus Infections Studies.

Leo C. James has a significant publication record featuring recent papers that explore SARS-CoV-2 and related molecular mechanisms. Some of the recent papers include:

  • "SARS-CoV-2 Infects the Brain Choroid Plexus and Disrupts the Blood-CSF Barrier in Human Brain Organoids" (2020, Cell stem cell)
  • "A thermostable, closed SARS-CoV-2 spike protein trimer" (2020, Nature Structural & Molecular Biology)
  • "Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion" (2021, PLoS Pathogens)
  • "Recurrent emergence and transmission of a SARS-CoV-2 spike deletion H69/V70" (2020, bioRxiv [Cold Spring Harbor Laboratory])
  • "Recurrent Emergence and Transmission of a SARS-CoV-2 Spike Deletion H69/V70" (2021, SSRN Electronic Journal)

The publications have appeared in prominent venues with multiple entries in journals and repositories such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Zenodo (CERN European Organization for Nuclear Research), Nature Structural & Molecular Biology, and PLoS Pathogens.

Frequent co-authors collaborating with Leo C. James include Marina Vaysburd, Anna Albecka, Donna L. Mallery, William A. McEwan, and John A. G. Briggs. These collaborations suggest a networked approach to research within their fields of study.

Best Publications

  • SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion.

    Petra Mlcochova;Steven A Kemp;Steven A Kemp;Mahesh Shanker Dhar;Guido Papa

  • Antibody Multispecificity Mediated by Conformational Diversity

    Leo C. James;Pietro Roversi;Dan S. Tawfik

  • Conformational diversity and protein evolution--a 60-year-old hypothesis revisited.

    Leo C. James;Dan S. Tawfik

  • HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency.

    Torsten Schaller;Karen E. Ocwieja;Jane Rasaiyaah;Amanda J. Price

  • Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)

    Donna L. Mallery;William A. McEwan;Susanna R. Bidgood;Greg J. Towers

  • HIV-1 evades innate immune recognition through specific cofactor recruitment

    Jane Rasaiyaah;Choon Ping Tan;Adam J. Fletcher;Amanda J. Price

  • SARS-CoV-2 Infects the Brain Choroid Plexus and Disrupts the Blood-CSF Barrier in Human Brain Organoids.

    Laura Pellegrini;Anna Albecka;Donna L. Mallery;Max J. Kellner

  • A Method for the Acute and Rapid Degradation of Endogenous Proteins

    Dean Clift;William A. McEwan;Larisa I. Labzin;Vera Konieczny

  • Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7.

    Bo Meng;Steven A Kemp;Steven A Kemp;Guido Papa;Rawlings Datir

  • Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function

    Leo C. James;Anthony H. Keeble;Zahra Khan;David A. Rhodes

  • A Large-Scale Conformational Change Couples Membrane Recruitment to Cargo Binding in the AP2 Clathrin Adaptor Complex

    Lauren P. Jackson;Bernard T. Kelly;Airlie J. McCoy;Thomas Gaffry

  • Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21

    William A McEwan;Jerry C H Tam;Ruth E Watkinson;Susanna R Bidgood

  • Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion.

    Guido Papa;Donna L. Mallery;Anna Albecka;Lawrence G. Welch

  • A thermostable, closed SARS-CoV-2 spike protein trimer.

    Xiaoli Xiong;Kun Qu;Katarzyna A. Ciazynska;Myra Hosmillo

  • Cellular self-defense: how cell-autonomous immunity protects against pathogens.

    Felix Randow;John D. MacMicking;Leo C. James

  • CPSF6 defines a conserved capsid interface that modulates HIV-1 replication.

    Amanda J. Price;Adam J. Fletcher;Torsten Schaller;Tom Elliott

  • Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly.

    Amanda J. Price;David A. Jacques;William A. McEwan;Adam J. Fletcher

  • HIV Integration Targeting: A Pathway Involving Transportin-3 and the Nuclear Pore Protein RanBP2

    Karen E. Ocwieja;Troy L. Brady;Keshet Ronen;Alyssa Huegel

  • Recurrent emergence and transmission of a SARS-CoV-2 Spike deletion ΔH69/V70

    Steven Kemp;Steven Kemp;Bo Meng;Isabella Ferreira;Rawlings Datir

  • A thermostable, closed, SARS-CoV-2 spike protein trimer

    Xiaoli Xiong;Kun Qu;Katarzyna A. Ciazynska;Myra Hosmillo

Frequent Co-Authors

Greg J. Towers
Greg J. Towers University College London
Jan Terje Andersen
Jan Terje Andersen University of Oslo
Inger Sandlie
Inger Sandlie University of Oslo
Jason W. Chin
Jason W. Chin MRC Laboratory of Molecular Biology
Ralf Wagner
Ralf Wagner University of Regensburg
Christopher M. Johnson
Christopher M. Johnson MRC Laboratory of Molecular Biology
Anurag A. Agrawal
Anurag A. Agrawal Cornell University
Davide Corti
Davide Corti Vir Biotechnology (Switzerland)
Dan S. Tawfik
Dan S. Tawfik Weizmann Institute of Science
Andrew M. L. Lever
Andrew M. L. Lever University of Cambridge

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