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Leonard C. Schalkwyk

Leonard C. Schalkwyk

D-Index & Metrics

Genetics

D-Index
72
Citations
21364
World Ranking
2111
National Ranking
264

Overview

Leonard C. Schalkwyk is affiliated with the University of Essex in the United Kingdom. Their research primarily falls within the field of Biochemistry, Genetics and Molecular Biology, with 62 publications contributing to this discipline. Within this broad area, they focus on specialized subfields including Molecular Biology, Genetics, Psychiatry and Mental Health, Pediatrics, Perinatology and Child Health, and Sociology and Political Science.

The central topics of Leonard C. Schalkwyk's work revolve around Epigenetics and DNA Methylation, which accounts for 52 publications. Other significant topics covered include Genetic Syndromes and Imprinting, RNA Modifications and Cancer, Birth, Development, and Health, Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities, Genomics and Chromatin Dynamics, and Intergenerational Family Dynamics and Caregiving.

The scientist has published several recent papers that reflect these interests. These include:

  • Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex (2020, Brain)
  • Full-length transcript sequencing of human and mouse cerebral cortex identifies widespread isoform diversity and alternative splicing (2021, Cell Reports)
  • A meta-analysis of epigenome-wide association studies in Alzheimer's disease highlights novel differentially methylated loci across cortex (2021, Nature Communications)
  • DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia (2021, eLife)
  • Characterising sex differences of autosomal DNA methylation in whole blood using the Illumina EPIC array (2022, Clinical Epigenetics)

Leonard C. Schalkwyk frequently collaborates with several coauthors who have contributed to multiple publications alongside them. These include Eilís Hannon, Jonathan Mill, Joe Burrage, Emma Dempster, and Meena Kumari.

The scientist's work is often published in several key venues. They have contributed 15 publications to bioRxiv (Cold Spring Harbor Laboratory), as well as multiple papers in European Neuropsychopharmacology (4 publications). In addition to these, they have published in Brain, Cell Reports, and Nature Communications, each with at least one publication.

Best Publications

  • The Collaborative Cross, a community resource for the genetic analysis of complex traits

    Gary A. Churchill;David C. Airey;Hooman Allayee;Joe M. Angel

  • A data-driven approach to preprocessing Illumina 450K methylation array data

    Ruth Pidsley;Chloe C Y Wong;Manuela Volta;Katie Lunnon

  • Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci.

    Philip Lawrence De Jager;Gyan Srivastava;Katie Lunnon;Jeremy Burgess

  • DNA methylation aging clocks: challenges and recommendations

    Christopher G Bell;Robert Lowe;Peter D Adams;Peter D Adams;Andrea A Baccarelli

  • Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood

    Matthew N Davies;Manuela Volta;Ruth Pidsley;Katie Lunnon

  • Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease

    Katie Lunnon;Rebecca Smith;Eilis Hannon;Philip L De Jager

  • The nature and identification of quantitative trait loci: a community's view.

    Oduola Abiola;Joe M. Angel;Philip Avner;Alexander A. Bachmanov

  • Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder

    Emma L. Dempster;Ruth Pidsley;Leonard C. Schalkwyk;Sheena Owens

  • Moderation of breastfeeding effects on the IQ by genetic variation in fatty acid metabolism

    Avshalom Caspi;Benjamin Williams;Julia Kim-Cohen;Ian W. Craig

  • Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

    J.L. Min;G. Hemani;E. Hannon;K.F. Dekkers

  • Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes.

    Eilis Hannon;Katie Lunnon;Leonard C Schalkwyk;Jonathan Mill

  • Transformation methods for halophilic archaebacteria.

    S W Cline;W L Lam;R L Charlebois;L C Schalkwyk

  • Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits

    Chloe Wong;Emma Meaburn;Angelica Ronald;Thomas Price

  • Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci

    Eilis Hannon;Helen Spiers;Joana Viana;Ruth Pidsley

  • An integrated genetic-epigenetic analysis of schizophrenia : evidence for co-localization of genetic associations and differential DNA methylation

    Eilis Hannon;Emma Dempster;Joana Viana;Joe Burrage

  • Genetic analysis of the mouse brain proteome

    Joachim Klose;Christina Nock;Marion Herrmann;Kai Stühler

  • Methylomic trajectories across human fetal brain development

    Helen Spiers;Eilis Hannon;Leonard C. Schalkwyk;Rebecca Smith

  • High resolution cosmid and P1 maps spanning the 14 Mb genome of the fission yeast S. pombe

    Jörg D. Hoheisel;Elmar Maier;Richard Mott;Linda McCarthy

  • Allelic skewing of DNA methylation is widespread across the genome.

    Leonard C. Schalkwyk;Emma L. Meaburn;Emma L. Meaburn;Rebecca Smith;Emma L. Dempster

  • Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

    Gyan Srivastava;Katie Lunnon;Jeremy Burgess;Lei Yu

Frequent Co-Authors

Jonathan Mill
Jonathan Mill University of Exeter
Robert Plomin
Robert Plomin King's College London
Ian W. Craig
Ian W. Craig King's College London
Hans Lehrach
Hans Lehrach Max Planck Society
Peter McGuffin
Peter McGuffin King's College London
Rudolf Uher
Rudolf Uher Dalhousie University
Sulev Kõks
Sulev Kõks Perron Institute for Neurological and Translational Science
Heinz Himmelbauer
Heinz Himmelbauer BOKU University
David A. Collier
David A. Collier Eli Lilly (United States)
Meena Kumari
Meena Kumari University of Essex

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