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Biology and Biochemistry

D-Index
74
Citations
16869
World Ranking
5704
National Ranking
165

Overview

Robert Ballotti is affiliated with Université Côte d'Azur in France. Their research spans the fields of biochemistry, genetics, molecular biology, and medicine, with a particular focus on molecular biology, oncology, ophthalmology, immunology, and cell biology.

Their main research topics include ocular oncology and treatments, melanoma and MAPK pathways, protein degradation and inhibitors, ubiquitin and proteasome pathways, immunotherapy and immune responses, cancer immunotherapy and biomarkers, as well as epigenetics and DNA methylation.

Frequent publication venues for Ballotti's work include Molecular Cancer, Journal of Investigative Dermatology, Cell Death and Differentiation, Cancers, and Theranostics.

Among their recent notable papers are:

  • "Single-cell RNA sequencing reveals intratumoral heterogeneity in primary uveal melanomas and identifies HES6 as a driver of the metastatic disease" (2021, Cell Death and Differentiation)
  • "The "ART" of Epigenetics in Melanoma: From histone "Alterations, to Resistance and Therapies"" (2020, Theranostics)
  • "The complex relationship between MITF and the immune system: a Melanoma ImmunoTherapy (response) Factor?" (2020, Molecular Cancer)
  • "Immune Checkpoints in Cancers: From Signaling to the Clinic" (2021, Cancers)
  • "Translation of single-cell transcriptomic analysis of uveal melanomas to clinical oncology" (2021, Progress in Retinal and Eye Research)

Robert Ballotti frequently collaborates with other researchers. Their most common co-authors include Corine Bertolotto, Thomas Strub, Yann Chéli, Karine Bille, and Arnaud Martel.

Best Publications

  • Cyclic AMP a Key Messenger in the Regulation of Skin Pigmentation

    Roser Buscà;Robert Ballotti

  • A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma

    Corine Bertolotto;Fabienne Lesueur;Sandy Giuliano;Thomas Strub

  • Microphthalmia Gene Product as a Signal Transducer in cAMP-Induced Differentiation of Melanocytes

    Corine Bertolotto;Patricia Abbe;Timothy J. Hemesath;Karine Bille

  • Different cis-Acting Elements Are Involved in the Regulation of TRP1 and TRP2 Promoter Activities by Cyclic AMP: Pivotal Role of M Boxes (GTCATGTGCT) and of Microphthalmia

    Corine Bertolotto;Roser Buscà;Patricia Abbe;Karine Bille

  • Nitric oxide produced by ultraviolet-irradiated keratinocytes stimulates melanogenesis.

    C Roméro-Graillet;E Aberdam;M Clément;J P Ortonne

  • Fifteen‐year quest for microphthalmia‐associated transcription factor target genes

    Yann Cheli;Mickael Ohanna;Robert Ballotti;Corine Bertolotto

  • Metformin inhibits melanoma development through autophagy and apoptosis mechanisms

    Tomic T;Botton T;Botton T;Cerezo M;Cerezo M;Robert G;Robert G

  • Inhibition of the Phosphatidylinositol 3-Kinase/p70S6-Kinase Pathway Induces B16 Melanoma Cell Differentiation

    Roser Buscà;Corine Bertolotto;Jean-Paul Ortonne;Robert Ballotti

  • Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes.

    Roser Buscà;Patricia Abbe;Fréderic Mantoux;Edith Aberdam

  • Senescent cells develop a PARP-1 and nuclear factor-κB-associated secretome (PNAS)

    Mickaël Ohanna;Sandy Giuliano;Caroline Bonet;Véronique Imbert

  • Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

    T Strub;S Giuliano;T Ye;C Bonet

  • Rab27a: A Key to Melanosome Transport in Human Melanocytes

    Philippe Bahadoran;Edith Aberdam;Frédéric Mantoux;Roser Buscà

  • Mitogen-activated Protein Kinase Pathway and AP-1 Are Activated during cAMP-induced Melanogenesis in B-16 Melanoma Cells

    Walter Englaro;Roger Rezzonico;Monique Durand-Clément;Dominique Lallemand

  • Ultraviolet B Radiation Acts through the Nitric Oxide and cGMP Signal Transduction Pathway to Stimulate Melanogenesis in Human Melanocytes

    Christine Roméro-Graillet;Edith Aberdam;Naïma Biagoli;William Massabni

  • Mitf is the key molecular switch between mouse or human melanoma initiating cells and their differentiated progeny

    Y Cheli;Y Cheli;S Guiliano;S Guiliano;T Botton;T Botton;S Rocchi;S Rocchi

  • Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance

    Michaël Cerezo;Michaël Cerezo;Abdelali Lehraiki;Abdelali Lehraiki;Antoine Millet;Florian Rouaud;Florian Rouaud

  • The Epithelial-Mesenchymal Transition (EMT) Regulatory Factor SLUG (SNAI2) Is a Downstream Target of SPARC and AKT in Promoting Melanoma Cell Invasion

    Nina Fenouille;Nina Fenouille;Mélanie Tichet;Mélanie Tichet;Maeva Dufies;Maeva Dufies;Anaïs Pottier;Anaïs Pottier

  • Glycogen Synthase Kinase 3β Is Activated by cAMP and Plays an Active Role in the Regulation of Melanogenesis

    Mehdi Khaled;Lionel Larribere;Karine Bille;Edith Aberdam

  • Involvement of microphthalmia in the inhibition of melanocyte lineage differentiation and of melanogenesis by agouti signal protein.

    E Aberdam;C Bertolotto;E V Sviderskaya;V de Thillot

  • Insulin receptor tyrosine kinase is defective in skeletal muscle of insulin-resistant obese mice.

    Yannick Le Marchand-Brustel;Thierry Grémeaux;Robert Ballotti;Emmanuel Van Obberghen

Frequent Co-Authors

Corine Bertolotto
Corine Bertolotto Université Côte d'Azur
Jean-Paul Ortonne
Jean-Paul Ortonne Grenoble Alpes University
Paul Hofman
Paul Hofman Grenoble Alpes University
Emmanuel Van Obberghen
Emmanuel Van Obberghen Université Côte d'Azur
Marcel Deckert
Marcel Deckert Université Côte d'Azur
Brigitte Bressac-de Paillerets
Brigitte Bressac-de Paillerets Institut Gustave Roussy
Irwin Davidson
Irwin Davidson Institute of Genetics and Molecular and Cellular Biology
Axel Ullrich
Axel Ullrich Max Planck Institute of Biochemistry
Patrick Auberger
Patrick Auberger Grenoble Alpes University
Lionel Larue
Lionel Larue University of Paris-Saclay

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