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Medicine

D-Index
85
Citations
20173
World Ranking
14793
National Ranking
7477

Overview

Jochen Schacht is affiliated with the University of Michigan-Ann Arbor in the United States. Their research contributions span various aspects of biochemistry, genetics, and molecular biology, with a focus on molecular biology, infectious diseases, and microbiology.

Their scholarly output has addressed several central topics, including:

  • RNA and protein synthesis mechanisms
  • Antimicrobial resistance in Staphylococcus
  • Antimicrobial peptides and activities
  • Mitochondrial function and pathology
  • DNA repair mechanisms

Jochen Schacht has published recent papers in established journals such as ChemMedChem and the International Journal of Molecular Sciences. Notable publications include:

  • "An Advanced Apralog with Increased in vitro and in vivo Activity toward Gram-negative Pathogens and Reduced ex vivo Cochleotoxicity" (2020, ChemMedChem)
  • "Phenotype of Mrps5-Associated Phylogenetic Polymorphisms Is Intimately Linked to Mitoribosomal Misreading" (2022, International Journal of Molecular Sciences)

Their work often involves collaboration with several frequent coauthors, who contribute to related research projects. These collaborators include:

  • Erik C. Böttger
  • Amr Sonousi
  • Jonathan C.K. Quirke
  • Prabuddha Waduge
  • Tanja Janusic

Their papers have appeared predominantly in the venues ChemMedChem and the International Journal of Molecular Sciences, each featuring at least one publication by Schacht. Their focus in these journals highlights expertise in molecular mechanisms and antimicrobial strategies.

Best Publications

  • Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals

    Su Hua Sha;Ruth Taylor;Andrew Forge;Jochen Schacht

  • Delayed production of free radicals following noise exposure.

    Daisuke Yamashita;Hong Yan Jiang;Jochen Schacht;Josef M. Miller;Josef M. Miller

  • Formation of free radicals by gentamicin and iron and evidence for an iron/gentamicin complex

    Eric M. Priuska;Jochen Schacht

  • Cisplatin and Aminoglycoside Antibiotics: Hearing Loss and Its Prevention

    Jochen Schacht;Andra E. Talaska;Leonard P. Rybak

  • Intense noise induces formation of vasoactive lipid peroxidation products in the cochlea.

    Yoshimitsu Ohinata;Josef M. Miller;Richard A. Altschuler;Jochen Schacht

  • New developments in aminoglycoside therapy and ototoxicity

    Jing Xie;Andra E. Talaska;Jochen Schacht

  • Glutathione limits noise-induced hearing loss.

    Yoshimitsu Ohinata;Yoshimitsu Ohinata;Tatsuya Yamasoba;Jochen Schacht;Josef M. Miller

  • Aminoglycoside ototoxicity in adult CBA, C57BL and BALB mice and the Sprague-Dawley rat

    Wei Jing Wu;Su Hua Sha;John D. McLaren;Kohei Kawamoto

  • Oxidative imbalance in the aging inner ear

    Hongyan Jiang;Andra E. Talaska;Jochen Schacht;Su Hua Sha

  • Development of novel aminoglycoside (NB54) with reduced toxicity and enhanced suppression of disease-causing premature stop mutations.

    Igor Nudelman;Annie Rebibo-Sabbah;Marina Cherniavsky;Valery Belakhov

  • Inhibition by neomycin of polyphosphoinositide turnover in subcellular fractions of guinea-pig cerebral cortex in vitro.

    Jochen Schacht

  • Protection from noise-induced lipid peroxidation and hair cell loss in the cochlea.

    Yoshimitsu Ohinata;Josef M. Miller;Josef M. Miller;Jochen Schacht

  • Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin.

    Tanja Matt;Chyan Leong Ng;Chyan Leong Ng;Kathrin Lang;Su Hua Sha;Su Hua Sha

  • Attenuation of cochlear damage from noise trauma by an iron chelator, a free radical scavenger and glial cell line-derived neurotrophic factor in vivo.

    Tatsuya Yamasoba;Jochen Schacht;Fumi Shoji;Josef M Miller

  • Caspase-independent pathways of hair cell death induced by kanamycin in vivo.

    H Jiang;SH Sha;A Forge;J Schacht

  • Antioxidant gene therapy can protect hearing and hair cells from ototoxicity.

    Kohei Kawamoto;Su Hua Sha;Ryosei Minoda;Ryosei Minoda;Masahiko Izumikawa;Masahiko Izumikawa

  • Increasing Intracellular Free Calcium Induces Circumferential Contractions in Isolated Cochlear Outer Hair Cells

    Didier Dulon;Gary Zajic;Jochen Schacht

  • The mitochondrion: A perpetrator of acquired hearing loss

    Erik C. Böttger;Jochen Schacht

  • Molecular mechanisms of drug-induced hearing loss.

    Jochen Schacht

  • Aspirin to Prevent Gentamicin-Induced Hearing Loss

    Su Hua Sha;Jian Hua Qiu;Jochen Schacht

Frequent Co-Authors

Josef M. Miller
Josef M. Miller University of Michigan–Ann Arbor
Richard A. Altschuler
Richard A. Altschuler University of Michigan–Ann Arbor
Erik C. Böttger
Erik C. Böttger University of Zurich
Yehoash Raphael
Yehoash Raphael University of Michigan–Ann Arbor
Andrea Vasella
Andrea Vasella ETH Zurich
David F. Dolan
David F. Dolan University of Michigan–Ann Arbor
David Crich
David Crich University of Georgia
Andrew Forge
Andrew Forge University College London
Bryan E. Pfingst
Bryan E. Pfingst University of Michigan–Ann Arbor

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