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Michael F. Hirshman

Michael F. Hirshman

D-Index & Metrics

Medicine

D-Index
90
Citations
34583
World Ranking
12094
National Ranking
6204

Overview

Michael F. Hirshman is affiliated with Harvard University in the United States and has contributed extensively to the field of Medicine, focusing on physiology and metabolic health. Their research spans several subfields including Physiology, Obstetrics and Gynecology, Pediatrics, Perinatology and Child Health, Molecular Biology, and Epidemiology.

Their work addresses key topics in adipose tissue and metabolism, birth and development health, inflammatory processes related to adipokines, gestational diabetes management, pregnancy-related studies including preeclampsia, cardiovascular disease related to adiposity, and exercise physiology.

Frequent co-authors in their publications include Laurie J. Goodyear, Pasquale Nigro, Roeland J.W. Middelbeek, Maria Vamvini, and Joji Kusuyama.

Michael F. Hirshman has published research in multiple academic venues, with recurring contributions to the journals Diabetes, Cell Metabolism, Cell Reports, Molecular Metabolism, and the Journal of the American Society of Nephrology.

Notable recent papers include:

  • Single-cell dissection of the obesity-exercise axis in adipose-muscle tissues implies a critical role for mesenchymal stem cells (2022, Cell Metabolism)
  • Placental superoxide dismutase 3 mediates benefits of maternal exercise on offspring health (2021, Cell Metabolism)
  • Maternal and paternal exercise regulate offspring metabolic health and beta cell phenotype (2020, BMJ Open Diabetes Research & Care)
  • Exercise training remodels inguinal white adipose tissue through adaptations in innervation, vascularization, and the extracellular matrix (2023, Cell Reports)
  • Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN (2020, Molecular Metabolism)

Best Publications

  • Role of AMP-activated protein kinase in mechanism of metformin action

    Gaochao Zhou;Robert Myers;Ying Li;Yuli Chen

  • Brown adipose tissue regulates glucose homeostasis and insulin sensitivity

    Kristin I. Stanford;Roeland J.W. Middelbeek;Kristy L. Townsend;Ding An

  • Evidence for 5' AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport

    Tatsuya Hayashi;Michael F Hirshman;Emily J Kurth;William W Winder

  • Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes.

    Nicolas Musi;Michael F. Hirshman;Jonas Nygren;Monika Svanfeldt

  • 5' AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle.

    E J Kurth-Kraczek;M F Hirshman;L J Goodyear;W W Winder

  • Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance.

    Zisman A;Peroni Od;Abel Ed;Michael

  • Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle

    M Sinha;Y. C. Jang;Y. C. Jang;Juhyun Oh;Juhyun Oh;Danika Mei Po Khong;Danika Mei Po Khong

  • Metabolic stress and altered glucose transport: activation of AMP-activated protein kinase as a unifying coupling mechanism.

    T Hayashi;M F Hirshman;N Fujii;S A Habinowski

  • Highly efficient, functional engraftment of skeletal muscle stem cells in dystrophic muscles.

    Massimiliano Cerletti;Sara Jurga;Sara Jurga;Carol A. Witczak;Michael F. Hirshman

  • Acute exercise induces GLUT4 translocation in skeletal muscle of normal human subjects and subjects with type 2 diabetes.

    J W Kennedy;M F Hirshman;E V Gervino;J V Ocel

  • Muscle-specific PPARγ-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones

    Andrew W. Norris;Lihong Chen;Simon J. Fisher;Ildiko Szanto

  • AMP-Activated Protein Kinase (AMPK) Is Activated in Muscle of Subjects With Type 2 Diabetes During Exercise

    Nicolas Musi;Nobuharu Fujii;Michael F. Hirshman;Ingvar Ekberg

  • Exercise induces isoform-specific increase in 5'AMP-activated protein kinase activity in human skeletal muscle.

    Nobuharu Fujii;Tatsuya Hayashi;Michael F. Hirshman;Jeremy T. Smith

  • Enhanced Peripheral and Splanchnic Insulin Sensitivity in NIDDM Men After Single Bout of Exercise

    John T Devlin;Michael Hirshman;Elizabeth D Horton;Edward S Horton

  • Distinct Signals Regulate AS160 Phosphorylation in Response to Insulin, AICAR, and Contraction in Mouse Skeletal Muscle

    Henning F. Kramer;Carol A. Witczak;Nobuharu Fujii;Niels Jessen

  • The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue

    Matthew D Lynes;Luiz O Leiria;Morten Lundh;Morten Lundh;Alexander Bartelt

  • Skeletal Muscle Adaptation to Exercise Training: AMP-Activated Protein Kinase Mediates Muscle Fiber Type Shift

    Katja S.C. Röckl;Michael F. Hirshman;Josef Brandauer;Nobuharu Fujii

  • Nitric oxide increases glucose uptake through a mechanism that is distinct from the insulin and contraction pathways in rat skeletal muscle.

    Yasuki Higaki;Michael F. Hirshman;Nobuharu Fujii;Laurie J. Goodyear

  • Increased Adenosine Monophosphate–Activated Protein Kinase Activity in Rat Hearts With Pressure-Overload Hypertrophy

    Rong Tian;Nicolas Musi;Jessica D'Agostino;Michael F. Hirshman

  • Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

    Franck Mauvais-Jarvis;Kohjiro Ueki;David A. Fruman;Michael F. Hirshman

Frequent Co-Authors

Laurie J. Goodyear
Laurie J. Goodyear Harvard University
Edward S. Horton
Edward S. Horton Harvard Medical School
Kei Sakamoto
Kei Sakamoto University of Copenhagen
C. Ronald Kahn
C. Ronald Kahn Harvard University
Eric B. Taylor
Eric B. Taylor University of British Columbia
Yu-Hua Tseng
Yu-Hua Tseng Harvard University
Olle Ljungqvist
Olle Ljungqvist Örebro University
Jørgen F. P. Wojtaszewski
Jørgen F. P. Wojtaszewski University of Copenhagen
Amy J. Wagers
Amy J. Wagers Harvard University
Lee A. Witters
Lee A. Witters Dartmouth College

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