World's Best Scientists 2026 revealed!

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Medicine

D-Index
106
Citations
58109
World Ranking
6390
National Ranking
621

Overview

I. Sadaf Farooqi is affiliated with the University of Cambridge in the United Kingdom. Their research primarily spans the field of Medicine, with a focused expertise in Endocrine and Autonomic Systems, Physiology, Nutrition and Dietetics, Genetics, and Molecular Biology.

The scientist's work addresses multiple aspects of metabolic health and obesity, with key topics including:

  • Regulation of Appetite and Obesity
  • Biochemical Analysis and Sensing Techniques
  • Adipose Tissue and Metabolism
  • Diet and Metabolism Studies
  • Adipokines, Inflammation, and Metabolic Diseases
  • Genetic Associations and Epidemiology
  • Pancreatic Function and Diabetes

Farooqi has contributed to several recent publications, illustrating the scope of their research interests:

  • Definition and diagnostic criteria of clinical obesity, 2025, The Lancet Diabetes & Endocrinology
  • Efficacy and safety of setmelanotide, an MC4R agonist, in individuals with severe obesity due to LEPR or POMC deficiency: single-arm, open-label, multicentre, phase 3 trials, 2020, The Lancet Diabetes & Endocrinology
  • The energy balance model of obesity: beyond calories in, calories out, 2022, American Journal of Clinical Nutrition
  • Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits, 2020, PLoS Genetics
  • Loss-of-function mutations in the melanocortin 4 receptor in a UK birth cohort, 2021, Nature Medicine

The scientist's collaborative network includes frequent co-authors such as:

  • Elana Henning
  • Martin Wabitsch
  • Julia M. Keogh
  • Jesús Argente
  • Katherine Lawler

Farooqi's research has been published across several prominent venues, reflecting a diverse dissemination of findings:

  • Journal of the Endocrine Society (11 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (6 publications)
  • The Lancet Diabetes & Endocrinology (5 publications)
  • Nature Medicine (5 publications)
  • The Journal of Clinical Endocrinology & Metabolism (5 publications)

The scientist's work predominantly explores mechanisms underlying obesity and metabolic disorders with an emphasis on genetic, physiological, and biochemical factors influencing appetite regulation and energy homeostasis.

Best Publications

  • Congenital leptin deficiency is associated with severe early-onset obesity in humans

    C T Montague;I S Farooqi;J P Whitehead;M A Soos

  • Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

    Elizabeth K. Speliotes;Elizabeth K. Speliotes;Cristen J. Willer;Sonja I. Berndt;Keri L. Monda

  • Effects of recombinant leptin therapy in a child with congenital leptin deficiency.

    I S Farooqi;S A Jebb;G Langmack;E Lawrence

  • Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

    Cristen J. Willer;Elizabeth K. Speliotes;Elizabeth K. Speliotes;Ruth J. F. Loos;Shengxu Li

  • Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene.

    I. Sadaf Farooqi;Julia M. Keogh;Giles S.H. Yeo;Emma J. Lank

  • Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

    I. Sadaf Farooqi;Giuseppe Matarese;Graham M. Lord;Julia M. Keogh

  • The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate–Dependent Nucleic Acid Demethylase

    Thomas Gerken;Christophe A. Girard;Yi-Chun Loraine Tung;Celia J. Webby

  • A frameshift mutation in MC4R associated with dominantly inherited human obesity

    G S Yeo;I S Farooqi;S Aminian;D J Halsall

  • Genetics of body-weight regulation

    Barsh Gs;Farooqi Is;O'Rahilly S

  • Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency

    I. Sadaf Farooqi;Giles S.H. Yeo;Julia M. Keogh;Shiva Aminian

  • Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor.

    I. Sadaf Farooqi;Teresia Wangensteen;Stephan Collins;Wendy Kimber

  • Genetics of Obesity in Humans

    I. Sadaf Farooqi;Stephen O’Rahilly

  • The Hormonal Control of Food Intake

    Anthony P. Coll;I. Sadaf Farooqi;Stephen O'Rahilly

  • Leptin Regulates Striatal Regions and Human Eating Behavior

    I. Sadaf Farooqi;Edward Bullmore;Julia Keogh;Jonathan Gillard

  • A de novo mutation affecting human TrkB associated with severe obesity and developmental delay

    Giles S H Yeo;Chiao-Chien Connie Hung;Justin Rochford;Julia Keogh

  • Large, rare chromosomal deletions associated with severe early-onset obesity

    Elena G. Bochukova;Ni Huang;Julia Keogh;Elana Henning

  • Obesity Associated Genetic Variation in FTO Is Associated with Diminished Satiety

    Jane Wardle;Susan Carnell;Claire M A Haworth;I Sadaf Farooqi

  • A new highly penetrant form of obesity due to deletions on chromosome 16p11.2

    R. G. Walters;S. Jacquemont;A. Valsesia;A. Valsesia;A. Valsesia;A. J. de Smith

  • Monogenic obesity in humans.

    I Sadaf Farooqi;Stephen O'Rahilly

  • The UK10K project identifies rare variants in health and disease

    Klaudia Walter;Josine L. Min;Jie Huang;Lucy Crooks

Frequent Co-Authors

Stephen O'Rahilly
Stephen O'Rahilly University of Cambridge
Inês Barroso
Inês Barroso University of Exeter
Nicholas J. Wareham
Nicholas J. Wareham University of Cambridge
Jian'an Luan
Jian'an Luan University of Cambridge
Philippe Froguel
Philippe Froguel Imperial College London
Paul C. Fletcher
Paul C. Fletcher University of Cambridge
Eleftheria Zeggini
Eleftheria Zeggini Technical University of Munich
Joel N. Hirschhorn
Joel N. Hirschhorn Boston Children's Hospital
Paul W. Franks
Paul W. Franks Lund University
Tim D. Spector
Tim D. Spector King's College London

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