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Thomas Grundström

Thomas Grundström

D-Index & Metrics

Molecular Biology

D-Index
44
Citations
6360
World Ranking
2934
National Ranking
39

Overview

Thomas Grundström is affiliated with Umeå University in Sweden. Their research primarily focuses on prostate cancer treatment and research, with a strong interest in related molecular and cellular pathways.

Their recent publication record includes studies on molecular oncology and cancer biology. Key recent papers are:

  • Targeted inhibition of ERα signaling and PIP5K1α/Akt pathways in castration-resistant prostate cancer, 2020, Molecular Oncology
  • PIP5K1α is Required for Promoting Tumor Progression in Castration-Resistant Prostate Cancer, 2022, Frontiers in Cell and Developmental Biology
  • Establishment of Prostate Tumor Growth and Metastasis Is Supported by Bone Marrow Cells and Is Mediated by PIP5K1α Lipid Kinase, 2020, Cancers
  • FcγRIIIa receptor interacts with androgen receptor and PIP5K1α to promote growth and metastasis of prostate cancer, 2021, Molecular Oncology
  • The transcription factor E2A can bind to and cleave single-stranded immunoglobulin heavy chain locus DNA, 2022, Molecular Immunology

Frequent publication venues for Grundström's work include:

  • Molecular Oncology
  • Frontiers in Cell and Developmental Biology
  • Cancers
  • Molecular Immunology

The scientist collaborates regularly with several co-authors who contribute to their research in oncology and molecular biology, such as:

  • Julius Semenas
  • Tianyan Wang
  • Jenny L. Persson
  • Azharuddin Sajid Syed Khaja
  • Athanasios Simoulis

Grundström's work spans across various fields of study, particularly:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology
  • Immunology and Microbiology

Within these broader domains, their research engages subfields including:

  • Molecular Biology
  • Immunology
  • Pulmonary and Respiratory Medicine
  • Oncology
  • Cancer Research

The main topics of scientific inquiry addressed by Grundström involve:

  • Prostate Cancer Treatment and Research
  • Ubiquitin and proteasome pathways
  • Cancer, Lipids, and Metabolism
  • RNA Research and Splicing
  • Cancer Cells and Metastasis
  • Immunotherapy and Immune Responses
  • Monoclonal and Polyclonal Antibodies Research

Best Publications

  • ampC cephalosporinase of Escherichia coli K-12 has a different evolutionary origin from that of beta-lactamases of the penicillinase type

    Bengtake Jaurin;Thomas Grundstrom

  • Oligonucleotide-directed mutagenesis by microscale ‘shot-gun’ gene synthesis

    Thomas Grundström;W.Martin Zenke;Marguerite Wintzerith;Hans W.D. Matthes

  • Francisella tularensis inhibits Toll‐like receptor‐mediated activation of intracellular signalling and secretion of TNF‐α and IL‐1 from murine macrophages

    Max Telepnev;Igor Golovliov;Thomas Grundström;Arne Tärnvik

  • Simultaneous rapid chemical synthesis of over one hundred oligonucleotides on a microscale.

    Hans W.D. Matthes;W. Martin Zenke;Thomas Grundström;Adrien Staub

  • The E. coli β -lactamase attenuator mediates growth rate-dependent regulation

    Bengtåke Jaurin;Thomas Grundström;Thomas Edlund;Staffan Normark

  • Stimulation of in vitro transcription from the SV40 early promoter by the enhancer involves a specific trans-acting factor.

    A.G. Wildeman;P. Sassone-Corsi;T. Grundström;M. Zenke

  • Smad and AML proteins synergistically confer transforming growth factor beta1 responsiveness to human germ-line IgA genes.

    E Pardali;X Q Xie;P Tsapogas;S Itoh

  • Purification of active human plasminogen activator inhibitor 1 from Escherichia coli. Comparison with natural and recombinant forms purified from eucaryotic cells.

    Daniel Lawrence;Leif Strandberg;Thomas Grundström;Tor Ny

  • Proline isomerism leads to multiple folded conformations of calbindin D9k: direct evidence from two-dimensional 1H NMR spectroscopy.

    Walter J. Chazin;Johan Kordel;Torbjorn Drakenberg;Eva Thulin

  • Isolation and characterization of DNA repetitions carrying the chromosomal β-lactamase gene of Escherichia coli K-12

    Thomas Edlund;Thomas Grundström;Staffan Normark

  • Differential protein binding in lymphocytes to a sequence in the enhancer of the mouse retrovirus SL3-3.

    A Thornell;B Hallberg;T Grundström

  • Sequence elements determining ampC promoter strength in E. coli.

    B Jaurin;T Grundström;S Normark

  • Calmodulin-dependent Kinase II Mediates T Cell Receptor/CD3- and Phorbol Ester-induced Activation of IκB Kinase

    Kate Hughes;Sofia Edin;Åsa Antonsson;Thomas Grundström

  • Helix-loop-helix transcriptional activators bind to a sequence in glucocorticoid response elements of retrovirus enhancers.

    B Corneliussen;A Thornell;B Hallberg;T Grundström

  • Overlap between ampC and frd operons on the Escherichia coli chromosome

    Thomas Grundstrom;Bengtake Jaurin

  • Location and nucleotide sequence of frdB, the gene coding for the iron-sulphur protein subunit of the fumarate reductase of Escherichia coli

    Stewart T. Cole;Thomas Grundström;Bengtåke Jaurin;John J. Robinson

  • A Novel, Heritable, Expanding CTG Repeat in an Intron of the SEF2-1 Gene on Chromosome 18q21.1

    T. S. Breschel;M. G. McInnis;R. L. Margolis;G. Sirugo

  • Escherichia coli K-12 Mutants Hyperproducing Chromosomal Beta-Lactamase by Gene Repetitions

    Staffan Normark;Thomas Edlund;Thomas Grundström;Sven Bergström

  • SL3-3 enhancer factor 1 transcriptional activators are required for tumor formation by SL3-3 murine leukemia virus.

    B Hallberg;J Schmidt;A Luz;F S Pedersen

  • Basic Helix-Loop-Helix Protein Sequences Determining Differential Inhibition by Calmodulin and S-100 Proteins *

    Jacqueline Onions;Stefan Hermann;Thomas Grundström

Frequent Co-Authors

Staffan Normark
Staffan Normark Karolinska Institute
Sture Forsén
Sture Forsén Lund University
Thomas Edlund
Thomas Edlund Umeå University
Torleif Härd
Torleif Härd Swedish University of Agricultural Sciences
Torbjörn Drakenberg
Torbjörn Drakenberg Lund University
Tor Ny
Tor Ny Umeå University
Daniel A. Lawrence
Daniel A. Lawrence University of Michigan–Ann Arbor
Uwe Sauer
Uwe Sauer ETH Zurich
Sara Linse
Sara Linse Lund University
Stephen R. Martin
Stephen R. Martin The Francis Crick Institute

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