World's Best Scientists 2026 revealed!
Thomas Edlund

Thomas Edlund

D-Index & Metrics

Biology and Biochemistry

D-Index
59
Citations
24769
World Ranking
12259
National Ranking
181

Research.com Recognitions

  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Enzyme

The scientist’s investigation covers issues in Cell biology, ISL1, Molecular biology, Pancreas morphogenesis and Genetics. His Cell biology study incorporates themes from Superoxide dismutase, Antioxidant and Glycoprotein. Thomas Edlund has researched Molecular biology in several fields, including Enhancer, NKX2-3, Enhancer binding and EMX2.

His Pancreas morphogenesis research includes elements of RFX6, Foregut, Pancreatic bud and Pancreas. The concepts of his Genetics study are interwoven with issues in Motor neuron, Neuroscience and Spinal cord. Thomas Edlund has included themes like Neurulation, Anatomy, Neural plate and Neural tube patterning in his Neuroscience study.

His most cited work include:

  • Insulin-promoter-factor 1 is required for pancreas development in mice (1588 citations)
  • Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes (918 citations)
  • Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord (815 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of study are Cell biology, Molecular biology, Genetics, Biochemistry and Neuroscience. His study in Cell biology is interdisciplinary in nature, drawing from both Internal medicine, Endocrinology, Cellular differentiation and Fibroblast growth factor. His research integrates issues of Enhancer, Enzyme, Enhancer binding and Complementary DNA in his study of Molecular biology.

His research in the fields of Motor neuron and Hindbrain overlaps with other disciplines such as Cell and molecular biology. His Motor neuron research incorporates elements of ISL1 and LHX3. His studies in Neural plate integrate themes in fields like Neurulation and Anatomy.

He most often published in these fields:

  • Cell biology (36.23%)
  • Molecular biology (31.88%)
  • Genetics (20.29%)

What were the highlights of his more recent work (between 2002-2018)?

  • Cell biology (36.23%)
  • Wnt signaling pathway (11.59%)
  • Neural plate (15.94%)

In recent papers he was focusing on the following fields of study:

His main research concerns Cell biology, Wnt signaling pathway, Neural plate, Neuroscience and Progenitor cell. His study brings together the fields of Cellular differentiation and Cell biology. His work carried out in the field of Wnt signaling pathway brings together such families of science as Neural tube and Fibroblast growth factor.

His Neural plate research includes themes of Gastrulation, Internal medicine and Endocrinology. Thomas Edlund combines subjects such as Neural crest and Neuregulin with his study of Neuroscience. His biological study deals with issues like Retinoic acid, which deal with fields such as Hindbrain, Hox gene, Motor neuron and Neural stem cell.

Between 2002 and 2018, his most popular works were:

  • Specification of dorsal telencephalic character by sequential Wnt and FGF signaling (167 citations)
  • An early role for WNT signaling in specifying neural patterns of Cdx and Hox gene expression and motor neuron subtype identity. (112 citations)
  • Wnt-regulated temporal control of BMP exposure directs the choice between neural plate border and epidermal fate. (101 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Enzyme

Thomas Edlund mainly investigates Wnt signaling pathway, Genetics, Cell biology, Neuroscience and Cell and molecular biology. His Wnt signaling pathway research is multidisciplinary, relying on both Fibroblast growth factor and Neural stem cell. The concepts of his Fibroblast growth factor study are interwoven with issues in Cerebrum, Cellular differentiation, Cerebral cortex, Sonic hedgehog and Frizzled.

Much of his study explores Frizzled relationship to Forebrain. The Neural stem cell study combines topics in areas such as Hox gene, Progenitor cell, Neural tube, Motor neuron and Retinoic acid. His Cell and molecular biology investigation overlaps with other disciplines such as Neural plate, Ectoderm, Border cells, Blastula and Gene expression.

Best Publications

  • Insulin-promoter-factor 1 is required for pancreas development in mice

    Jörgen Jonsson;Lena Carlsson;Thomas Edlund;Helena Edlund

  • Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes

    T. Tsuchida;M. Ensini;S.B. Morton;M. Baldassare

  • IPF1, a homeodomain-containing transactivator of the insulin gene.

    H Ohlsson;K Karlsson;T Edlund

  • Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord

    H. Roelink;A. Augsburger;J. Heemskerk;V. Korzh

  • Cell-specific expression of the rat insulin gene: evidence for role of two distinct 5' flanking elements

    T Edlund;Walker;PJ Barr;WJ Rutter

  • Requirement for LIM Homeobox Gene Isl1 in Motor Neuron Generation Reveals a Motor Neuron– Dependent Step in Interneuron Differentiation

    Samuel L. Pfaff;Monica Mendelsohn;Colin L. Stewart;Thomas Edlund

  • Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells

    Ulf Ahlgren;Samuel L. Pfaff;Samuel L. Pfaff;Thomas M. Jessell;Thomas Edlund

  • Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo-and a Cys–His domain

    Olof Karlsson;Stefan Thor;Torbjörn Norberg;Helena Ohlsson

  • Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genes

    Michael D. Walker;Thomas Edlund;Anne M. Boulet;William J. Rutter

  • Early stages of motor neuron differentiation revealed by expression of homeobox gene Islet-1

    Johan Ericson;Stefan Thor;Thomas Edlund;Thomas M. Jessell;Thomas M. Jessell

  • Progression from Extrinsic to Intrinsic Signaling in Cell Fate Specification: A View from the Nervous System

    Thomas Edlund;Thomas M Jessell

  • Control of cell pattern in the neural tube: motor neuron induction by diffusible factors from notochord and floor plate.

    Toshiya Yamada;Samuel L. Pfaff;Thomas Edlund;Thomas M. Jessell

  • Sonic hedgehog induces the differentiation of ventral forebrain neurons: A common signal for ventral patterning within the neural tube

    J Ericson;J Muhr;M Placzek;T Lints

  • Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia.

    L M Carlsson;J Jonsson;T Edlund;S L Marklund

  • CONTROL OF CELL PATTERN IN THE NEURAL TUBE: REGULATION OF CELL DIFFERENTIATION BY DORSALIN-1,A NOVEL TGF-BETA FAMILY MEMBER

    Konrad Basler;Thomas Edlund;Thomas M. Jessell;Toshiya Yamada

  • An early requirement for FGF signalling in the acquisition of neural cell fate in the chick embryo.

    Sara I Wilson;Enrique Graziano;Richard Harland;Thomas M Jessell

  • The status of Wnt signalling regulates neural and epidermal fates in the chick embryo

    Sara Wilson;Anna Rydström;Tolleiv Trimborn;Karl Willert

  • Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary

    Johan Ericson;Stefan Norlin;Thomas M. Jessell;Thomas Edlund

  • Neural induction: toward a unifying mechanism

    Sara I. Wilson;Thomas Edlund

  • Progressive induction of caudal neural character by graded Wnt signaling.

    Ulrika Nordström;Thomas M. Jessell;Thomas Edlund

Frequent Co-Authors

Thomas M. Jessell
Thomas M. Jessell Columbia University
Stefan L. Marklund
Stefan L. Marklund Umeå University
Staffan Normark
Staffan Normark Karolinska Institute
Thomas Grundström
Thomas Grundström Umeå University
Samuel L. Pfaff
Samuel L. Pfaff Salk Institute for Biological Studies
Johan Ericson
Johan Ericson Karolinska Institute
Hans Wolf-Watz
Hans Wolf-Watz Umeå University
Åke Engström
Åke Engström Uppsala University
Vladimir Korzh
Vladimir Korzh United Way
Glenn R. Björk
Glenn R. Björk Umeå University

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