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Neuroscience

D-Index
44
Citations
11380
World Ranking
7059
National Ranking
3050

Overview

Hongjie Yuan is affiliated with Emory University in the United States and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and neuroscience. Their work spans multiple subfields, including molecular biology, cellular and molecular neuroscience, genetics, psychiatry and mental health, and pharmacology.

The primary research directions encompass neuroscience and neuropharmacology, genetics and neurodevelopmental disorders, ion channel regulation and function, receptor mechanisms and signaling, RNA and protein synthesis mechanisms, genomics and rare diseases, and epilepsy research and treatment.

Yuan has published in several notable scientific journals. Frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cellular and Molecular Life Sciences
  • Brain
  • Neuropharmacology
  • The Journal of Physiology

Their recent papers reflect core research interests in receptor function and neuropharmacology:

  • Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels, 2021, Pharmacological Reviews
  • Therapeutic potential of N-methyl-D-aspartate receptor modulators in psychiatry, 2023, Neuropsychopharmacology
  • Modelling and treating GRIN2A developmental and epileptic encephalopathy in mice, 2020, Brain
  • Clinical and therapeutic significance of genetic variation in the GRIN gene family encoding NMDARs, 2021, Neuropharmacology
  • Biased modulators of NMDA receptors control channel opening and ion selectivity, 2020, Nature Chemical Biology

Collaboration plays a significant role in Yuan's work, with frequent co-authors including Stephen F. Traynelis, Riley E. Perszyk, Scott J. Myers, Sukhan Kim, and Jiahui Chen. These partnerships highlight a collaborative network centered around neuropharmacology and molecular neuroscience.

Best Publications

  • Glutamate Receptor Ion Channels: Structure, Regulation, and Function

    Stephen Traynelis;Lonnie P. Wollmuth;Chris J. McBain;Frank S. Menniti

  • Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.

    Kasper B. Hansen;Lonnie P. Wollmuth;Derek Bowie;Hiro Furukawa

  • Protective role of ATP-sensitive potassium channels in hypoxia-induced generalized seizure.

    Katsuya Yamada;Juan Juan Ji;Hongjie Yuan;Takashi Miki

  • Distinct Functional and Pharmacological Properties of Triheteromeric GluN1/GluN2A/GluN2B NMDA Receptors

    Kasper B. Hansen;Kevin Kevin K Ogden;Hongjie Yuan;Stephen F. Traynelis

  • GRIN2A mutation and early‐onset epileptic encephalopathy: personalized therapy with memantine

    Tyler Mark Pierson;Hongjie Yuan;Eric D. Marsh;Karin Fuentes-Fajardo

  • GRIN2B encephalopathy: Novel findings on phenotype, variant clustering, functional consequences and treatment aspects

    Konrad Platzer;Hongjie Yuan;Hannah Schütz;Alexander Winschel

  • Control of NMDA receptor function by the NR2 subunit amino-terminal domain.

    Hongjie Yuan;Kasper B. Hansen;Katie M. Vance;Kevin K. Ogden

  • Human GRIN2B variants in neurodevelopmental disorders

    Chun Hu;Wenjuan Chen;Scott J. Myers;Hongjie Yuan

  • Astrocytic control of synaptic NMDA receptors

    C. Justin Lee;Guido Mannaioni;Hongjie Yuan;Dong Hoo Woo

  • Structural features of the glutamate binding site in recombinant NR1/NR2A N-methyl-D-aspartate receptors determined by site-directed mutagenesis and molecular modeling

    Philip E Chen;Matthew T Geballe;Phillip J Stansfeld;Alexander R Johnston

  • Ionotropic GABA and Glutamate Receptor Mutations and Human Neurologic Diseases

    Hongjie Yuan;Chian-Ming Low;Olivia A. Moody;Andrew Jenkins

  • Subunit-specific mechanisms and proton sensitivity of NMDA receptor channel block

    Shashank M. Dravid;Kevin Erreger;Hongjie Yuan;Katherine Nicholson

  • Subunit-specific agonist activity at NR2A-, NR2B-, NR2C-, and NR2D-containing N-methyl-D-aspartate glutamate receptors

    Kevin Erreger;Matthew T Geballe;Anders S Kristensen;Philip E Chen

  • GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel Blockers

    Dong Li;Hongjie Yuan;Xilma R. Ortiz-Gonzalez;Xilma R. Ortiz-Gonzalez;Eric D. Marsh;Eric D. Marsh

  • Mechanistic Insight into NMDA Receptor Dysregulation by Rare Variants in the GluN2A and GluN2B Agonist Binding Domains

    Sharon A. Swanger;Wenjuan Chen;Gordon Wells;Pieter B. Burger

  • A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors.

    Praseeda Mullasseril;Kasper B Hansen;Katie M Vance;Kevin K Ogden

  • Functional analysis of a de novo GRIN2A missense mutation associated with early-onset epileptic encephalopathy

    Hongjie Yuan;Kasper B. Hansen;Jing Zhang;Tyler Mark Pierson

  • Distinct roles of GRIN2A and GRIN2B variants in neurological conditions

    Scott J Myers;Hongjie Yuan;Jing-Qiong Kang;Francis Chee Kuan Tan

  • De Novo Mutations and Rare Variants Occurring in NMDA Receptors.

    Wenshu XiangWei;Yuwu Jiang;Hongjie Yuan

  • Conserved structural and functional control of N-methyl-D-aspartate receptor gating by transmembrane domain M3

    Hongjie Yuan;Kevin Erreger;Shashank M. Dravid;Stephen F. Traynelis

  • Molecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology.

    Kevin K. Ogden;Wenjuan Chen;Wenjuan Chen;Sharon A. Swanger;Miranda J. McDaniel

Frequent Co-Authors

William B. Dobyns
William B. Dobyns University of Minnesota
Raymond Dingledine
Raymond Dingledine Emory University
Christel Depienne
Christel Depienne Essen University Hospital
Katherine L. Helbig
Katherine L. Helbig Children's Hospital of Philadelphia
Slavé Petrovski
Slavé Petrovski AstraZeneca (United Kingdom)
Chris J. McBain
Chris J. McBain National Institutes of Health
Heather C. Mefford
Heather C. Mefford University of Washington
Eric D. Marsh
Eric D. Marsh Children's Hospital of Philadelphia
Rikke S. Møller
Rikke S. Møller University of Southern Denmark
Elias Aizenman
Elias Aizenman University of Pittsburgh

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Related Online Degrees & Career Pathways

Neuroscience is a versatile field, often intersecting with psychology, mental health, and social work. Students interested in exploring related areas may consider a bachelors in psychology online. This flexible option provides a solid foundation in human behavior and cognitive processes, complementing neuroscience studies and broadening career opportunities.

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If you’re seeking a faster route to clinical practice, accelerated online mft programs offer intensive training for marriage and family therapy. This specialty is in demand and closely relates to neuroscience through behavioral interventions and counseling approaches.

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