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Neuroscience

D-Index
46
Citations
14776
World Ranking
6572
National Ranking
516

Overview

Mark Farrant is affiliated with University College London in the United Kingdom. Their research spans multiple areas within biochemistry, genetics, molecular biology, and neuroscience, with active contributions to both primary and subfields of study.

The main fields of study for Mark Farrant include:

  • Biochemistry, Genetics and Molecular Biology
  • Neuroscience

Further specialization is evident in the following subfields:

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Genetics
  • Surgery
  • Developmental Neuroscience

The main topics covered in their work reflect a focus on neural and genetic mechanisms, such as:

  • Neuroscience and Neuropharmacology Research
  • Ion channel regulation and function
  • Genetics and Neurodevelopmental Disorders
  • RNA regulation and disease
  • Mitochondrial Function and Pathology
  • Genomics and Rare Diseases
  • Receptor Mechanisms and Signaling

Mark Farrant has authored numerous papers, among which the following are representative of their recent work:

  • "Ca2+-permeable AMPA receptors and their auxiliary subunits in synaptic plasticity and disease," 2021, The Journal of Physiology
  • "Transient developmental imbalance of cortical interneuron subtypes presages long-term changes in behavior," 2021, Cell Reports
  • "A gain-of-function GRIA2 variant associated with neurodevelopmental delay and seizures: Functional characterization and targeted treatment," 2022, Epilepsia
  • "Enhanced functional detection of synaptic calcium-permeable AMPA receptors using intracellular NASPM," 2023, eLife
  • "Influence of the TARP γ8-Selective Negative Allosteric Modulator JNJ-55511118 on AMPA Receptor Gating and Channel Conductance," 2022, Molecular Pharmacology

The frequent co-authors collaborating with Mark Farrant include:

  • Stuart Cull-Candy
  • Ian D. Coombs
  • Cécile Bats
  • Dorota Studniarczyk
  • Craig A. Sexton

The primary publication venues for their research are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Neuroscience
  • The Journal of Physiology
  • Cell Reports
  • Epilepsia

Best Publications

  • Variations on an inhibitory theme : phasic and tonic activation of GABA(A) receptors

    Mark Farrant;Zoltan Nusser

  • NMDA receptor subunits: Diversity, development and disease

    Stuart Cull-Candy;Stephen Brickley;Mark Farrant

  • Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by δ subunit-containing GABAA receptors

    Brandon M. Stell;Stephen G. Brickley;C. Y. Tang;Mark Farrant

  • Development of a tonic form of synaptic inhibition in rat cerebellar granule cells resulting from persistent activation of GABAA receptors.

    S G Brickley;S G Cull-Candy;M Farrant

  • Adaptive regulation of neuronal excitability by a voltage- independent potassium conductance

    Stephen G. Brickley;Victoria Revilla;Stuart G. Cull-Candy;William Wisden

  • Regulation of Ca2+-permeable AMPA receptors: synaptic plasticity and beyond.

    Stuart Cull-Candy;Leah Kelly;Mark Farrant

  • Differences in Synaptic GABAA Receptor Number Underlie Variation in GABA Mini Amplitude

    Zoltan Nusser;Zoltan Nusser;Stuart Cull-Candy;Mark Farrant

  • The cellular, molecular and ionic basis of GABA(A) receptor signalling.

    Mark Farrant;Kai Kaila

  • NMDA-receptor channel diversity in the developing cerebellum

    Mark Farrant;Dirk Feldmeyer;Tomoyuki Takahashi;Stuart G. Cull-Candy

  • Primary sclerosing cholangitis: refinement and validation of survival models.

    E.Rolland Dickson;Paul A. Murtaugh;Russell H. Wiesner;Patricia M. Grambsch

  • Synaptic inhibition of Purkinje cells mediates consolidation of vestibulo-cerebellar motor learning

    Peer Wulff;Martijn Schonewille;Massimiliano Renzi;Laura Viltono

  • Single-channel properties of synaptic and extrasynaptic GABAA receptors suggest differential targeting of receptor subtypes.

    Stephen G. Brickley;Stuart G. Cull-Candy;Mark Farrant

  • Whole‐cell and single‐channel currents activated by GABA and glycine in granule cells of the rat cerebellum.

    M Kaneda;M Farrant;S G Cull-Candy

  • GABAergic regulation of cerebellar NG2 cell development is altered in perinatal white matter injury

    Marzieh Zonouzi;Joseph Scafidi;Peijun Li;Brian McEllin

  • Stargazin attenuates intracellular polyamine block of calcium-permeable AMPA receptors

    David Soto;Ian D Coombs;Leah Kelly;Mark Farrant

  • neuroConstruct: A Tool for Modeling Networks of Neurons in 3D Space

    Padraig Gleeson;Volker Steuber;R. Angus Silver

  • From synapse to behavior: rapid modulation of defined neuronal types with engineered GABAA receptors.

    Peer Wulff;Thomas Goetz;Thomas Goetz;Elli Leppä;Anni Maija Linden

  • GABA spillover from single inhibitory axons suppresses low-frequency excitatory transmission at the cerebellar glomerulus.

    Simon J. Mitchell;R. Angus Silver

  • Maturation of EPSCs and Intrinsic Membrane Properties Enhances Precision at a Cerebellar Synapse

    Laurence Cathala;Stephen Brickley;Stuart Cull-Candy;Mark Farrant

  • EXCITATORY AMINO-ACID RECEPTOR-CHANNELS IN PURKINJE-CELLS IN THIN CEREBELLAR SLICES

    Mark Farrant;Stuart Graham Cull-Candy

Frequent Co-Authors

Stuart G. Cull-Candy
Stuart G. Cull-Candy University College London
Stephen G. Brickley
Stephen G. Brickley Imperial College London
David Soto
David Soto Basque Center on Cognition, Brain and Language
William Wisden
William Wisden Imperial College London
Zoltan Nusser
Zoltan Nusser Hungarian Academy of Sciences
P. Jesper Sjöström
P. Jesper Sjöström McGill University
Freek E. Hoebeek
Freek E. Hoebeek Utrecht University
Esa R. Korpi
Esa R. Korpi University of Helsinki
David H. Farb
David H. Farb Boston University
Roger A. Nicoll
Roger A. Nicoll University of California, San Francisco

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