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Daniel Ladant

Daniel Ladant

D-Index & Metrics

Biology and Biochemistry

D-Index
60
Citations
12394
World Ranking
11992
National Ranking
433

Overview

Daniel Ladant is affiliated with the Institut Pasteur in France, contributing extensively to the field of Biochemistry, Genetics and Molecular Biology. Their research predominantly focuses on Molecular Biology, Genetics, Microbiology, Endocrinology, and Cell Biology.

Their work covers a diverse range of scientific topics, including:

  • Bacterial Infections and Vaccines
  • RNA and protein synthesis mechanisms
  • Bacterial Genetics and Biotechnology
  • Protein Structure and Dynamics
  • Bacillus and Francisella bacterial research
  • Bacterial biofilms and quorum sensing
  • Yersinia bacterium, plague, ectoparasites research

Their publication record includes numerous research papers published in prevalent scientific venues such as bioRxiv (Cold Spring Harbor Laboratory), Biophysical Journal, Toxins, Methods in Molecular Biology, and BMC Biology.

Selected recent publications highlight the breadth of their research:

  • Bioengineering of Bordetella pertussis Adenylate Cyclase Toxin for Vaccine Development and Other Biotechnological Purposes, 2021, Toxins
  • Interaction network among de novo purine nucleotide biosynthesis enzymes in Escherichia coli, 2023, FEBS Journal
  • Prevalence of ExoY Activity in Pseudomonas aeruginosa Reference Panel Strains and Impact on Cytotoxicity in Epithelial Cells, 2021, Frontiers in Microbiology
  • A High-Affinity Calmodulin-Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells, 2021, Advanced Science
  • Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium, 2022, BMC Biology

Collaboration is a significant aspect of their research activities. Frequent co-authors include Alexandre Chenal, Dorothée Raoux-Barbot, Mirko Sadi, Sébastien Brier, and Sylviane Hoos, reflecting a network of scientific partnerships.

Best Publications

  • A bacterial two-hybrid system based on a reconstituted signal transduction pathway

    Gouzel Karimova;Josette Pidoux;Agnes Ullmann;Daniel Ladant

  • The comprehensive sourcebook of bacterial protein toxins

    Michel R. Popoff;Joseph Alouf;Daniel Ladant

  • Interaction Network among Escherichia coli Membrane Proteins Involved in Cell Division as Revealed by Bacterial Two-Hybrid Analysis

    Gouzel Karimova;Nathalie Dautin;Daniel Ladant

  • The Adenylate Cyclase Toxin of Bordetella pertussis Binds to Target Cells via the αMβ2 Integrin (Cd11b/Cd18)

    Pierre Guermonprez;Nadia Khelef;Eric Blouin;Philippe Rieu

  • Bordetella pertussis adenylate cyclase: a toxin with multiple talents

    Daniel Ladant;Agnes Ullmann

  • The calmodulin-sensitive adenylate cyclase of Bordetella pertussis: cloning and expression in Escherichia col.

    P. Glaser;D. Ladant;O. Sezer;F. Pichot

  • Interaction of Calcium with Bordetella pertussis Adenylate Cyclase Toxin CHARACTERIZATION OF MULTIPLE CALCIUM-BINDING SITES AND CALCIUM-INDUCED CONFORMATIONAL CHANGES

    Thierry Rose;Peter Sebo;Jacques Bellalou;Daniel Ladant

  • Adenylate cyclase toxin (CyaA) of Bordetella pertussis. Evidence for the formation of small ion-permeable channels and comparison with HlyA of Escherichia coli.

    R Benz;E Maier;D Ladant;A Ullmann

  • Interaction of Bordetella pertussis adenylate cyclase with calmodulin. Identification of two separated calmodulin-binding domains.

    D Ladant

  • Protein-protein interaction between Bacillus stearothermophilus tyrosyl-tRNA synthetase subdomains revealed by a bacterial two-hybrid system.

    Karimova G;Ullmann A;Ladant D

  • A bacterial two-hybrid system that exploits a cAMP signaling cascade in Escherichia coli.

    Gouzel Karimova;Agnes Ullmann;Daniel Ladant

  • Interaction of Bordetella pertussis adenylate cyclase with CD11b/CD18: Role of toxin acylation and identification of the main integrin interaction domain.

    Mohammed El-Azami-El-Idrissi;Cécile Bauche;Jirina Loucka;Radim Osicka

  • Deletions affecting hemolytic and toxin activities of Bordetella pertussis adenylate cyclase.

    J Bellalou;H Sakamoto;D Ladant;C Geoffroy

  • RTX calcium binding motifs are intrinsically disordered in the absence of calcium: implication for protein secretion.

    Alexandre Chenal;J.Iñaki Guijarro;Bertrand Raynal;Muriel Delepierre

  • Identification of residues essential for catalysis and binding of calmodulin in Bordetella pertussis adenylate cyclase by site-directed mutagenesis.

    P Glaser;A Elmaoglou-Lazaridou;E Krin;D Ladant

  • In vivo induction of CTL responses by recombinant adenylate cyclase of Bordetella pertussis carrying viral CD8+ T cell epitopes.

    C Fayolle;P Sebo;D Ladant;A Ullmann

  • Eradication of Established Tumors by Vaccination With Recombinant Bordetella pertussis Adenylate Cyclase Carrying the Human Papillomavirus 16 E7 Oncoprotein

    Xavier Préville;Daniel Ladant;Benedikt Timmerman;Claude Leclerc

  • Bordetella pertussis adenylate cyclase. Purification, characterization, and radioimmunoassay.

    D Ladant;C Brezin;J M Alonso;I Crenon

  • An Increase in Antimycobacterial Th1-Cell Responses by Prime-Boost Protocols of Immunization Does Not Enhance Protection against Tuberculosis

    Laleh Majlessi;Marcela Simsova;Zdenka Jarvis;Priscille Brodin

  • Bordetella pertussis adenylate cyclase: a toxin with multiple talents.

    Sophie Goyard;Peter Šebo;Olivier D'Andria;Daniel Ladant

Frequent Co-Authors

Agnes Ullmann
Agnes Ullmann Institut Pasteur
Peter Sebo
Peter Sebo Czech Academy of Sciences
Antoine Danchin
Antoine Danchin Institut Cochin
Philippe Glaser
Philippe Glaser Institut Pasteur
Nicole Guiso
Nicole Guiso Institut Pasteur
Dominique Durand
Dominique Durand Case Western Reserve University
Cesare Montecucco
Cesare Montecucco University of Padua
Abdelkader Namane
Abdelkader Namane Institut Pasteur
Philippe J. Sansonetti
Philippe J. Sansonetti Institut Pasteur

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