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Biology and Biochemistry

D-Index
45
Citations
7463
World Ranking
19121
National Ranking
435

Overview

Isabel Guerrero is affiliated with the Centro de Biología Molecular Severo Ochoa in Spain. Their research primarily focuses on Biochemistry, Genetics, and Molecular Biology, with significant contributions in the subfields of Molecular Biology, Genetics, and Cell Biology. Additional areas of study include Epidemiology and Cellular and Molecular Neuroscience.

Guerrero's work encompasses various main topics including:

  • Hedgehog Signaling Pathway Studies
  • Developmental Biology and Gene Regulation
  • Wnt/β-catenin signaling in development and cancer
  • Hippo pathway signaling and YAP/TAZ
  • CRISPR and Genetic Engineering
  • Microtubule and mitosis dynamics
  • Genetic and Kidney Cyst Diseases

The scientist has published multiple papers in peer-reviewed journals, with notable recent papers including:

  • Polarized sorting of Patched enables cytoneme-mediated Hedgehog reception in the Drosophila wing disc, 2020, The EMBO Journal
  • Glypicans define unique roles for the Hedgehog co-receptors boi and ihog in cytoneme-mediated gradient formation, 2021, eLife
  • Hedgehog on the Move: Glypican-Regulated Transport and Gradient Formation in Drosophila, 2024, Cells
  • Predictive model for cytoneme guidance in Hedgehog signaling based on Ihog-Glypicans interaction, 2022, Nature Communications
  • Improving the understanding of cytoneme-mediated morphogen gradients by in silico modeling, 2021, PLoS Computational Biology

Frequent co-authors of Guerrero include:

  • Carlos Jiménez-Jiménez
  • Adrián Aguirre-Tamaral
  • Gustavo Aguilar
  • D. Sánchez-Hernández
  • Kay Grobe

Their research has appeared repeatedly in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • ADO Medical
  • Cells
  • The EMBO Journal

Best Publications

  • Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings.

    J Capdevila;I Guerrero

  • A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched.

    Y. Nakano;I. Guerrero;A. Hidalgo;A. Taylor

  • Differential expression of the ras gene family in mice.

    J Leon;I Guerrero;A Pellicer

  • The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development.

    J. Capdevila;M.P. Estrada;E. Sánchez-Herrero;I. Guerrero

  • Cytonemes are required for the establishment of a normal Hedgehog morphogen gradient in Drosophila epithelia

    Marcus Bischoff;Ana-Citlali Gradilla;Irene Seijo;Germán Andrés

  • A molecular approach to leukemogenesis: mouse lymphomas contain an activated c-ras oncogene

    Isabel Guerrero;Pablo Calzada;Allen Mayer;Angel Pellicer

  • Activation of a c-K-ras oncogene by somatic mutation in mouse lymphomas induced by gamma radiation.

    Isabel Guerrero;Alfredo Villasante;Victor Corces;Angel Pellicer

  • Exosomes as Hedgehog carriers in cytoneme-mediated transport and secretion

    Ana-Citlali Gradilla;Esperanza González;Irene Seijo;German Andrés

  • The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking

    Verónica Martı́n;Graciela Carrillo;Carlos Torroja;Isabel Guerrero

  • Patched controls the Hedgehog gradient by endocytosis in a dynamin-dependent manner, but this internalization does not play a major role in signal transduction

    Carlos Torroja;Nicole Gorfinkiel;Isabel Guerrero

  • The homeobox gene Distal-less induces ventral appendage development in Drosophila

    Nicole Gorfinkiel;Ginés Morata;Isabel Guerrero

  • Hedgehog activity, independent of decapentaplegic, participates in wing disc patterning.

    José Luis Mullor;Manuel Calleja;Javier Capdevila;Isabel Guerrero

  • Cytoneme-mediated delivery of hedgehog regulates the expression of bone morphogenetic proteins to maintain germline stem cells in Drosophila.

    Patricia Rojas-Ríos;Isabel Guerrero;Acaimo González-Reyes

  • Activated N‐ras gene induces neuronal differentiation of PC12 rat pheochromocytoma cells

    Isabel Guerrero;Henry Wong;Angel Pellicer;David E. Burstein

  • Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epithelium

    Ainhoa Callejo;Aphrodite Bilioni;Emanuela Mollica;Nicole Gorfinkiel

  • The function of engrailed and the specification of Drosophila wing pattern

    Isabel Guillén;José L. Mullor;Javier Capdevila;Ernesto Sánchez-Herrero

  • Mutational activation of oncogenes in animal model systems of carcinogenesis (MTR 07217)

    Isabel Guerrero;Angel Pellicer

  • Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix.

    Ainhoa Callejo;Carlos Torroja;Luis Quijada;Isabel Guerrero

  • Loss of the normal N-ras allele in a mouse thymic lymphoma induced by a chemical carcinogen

    Isabel Guerrero;Alfredo Villasante;Victor Corces;Angel Pellicer

  • Cytoneme-mediated cell-cell contacts for Hedgehog reception

    Laura González-Méndez;Irene Seijo-Barandiarán;Isabel Guerrero

Frequent Co-Authors

Angel Pellicer
Angel Pellicer New York University
Juan Soler
Juan Soler University of Granada
Alan Carleton
Alan Carleton University of Geneva
David E. Burstein
David E. Burstein Tel Aviv University
Hernando A. del Portillo
Hernando A. del Portillo University of Barcelona
Joaquín Arribas
Joaquín Arribas Institució Catalana de Recerca i Estudis Avançats
Ginés Morata
Ginés Morata Spanish National Research Council
Victor G. Corces
Victor G. Corces Emory University
Philip W. Ingham
Philip W. Ingham University of Bath

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