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Shamil R. Sunyaev

Shamil R. Sunyaev

D-Index & Metrics

Genetics

D-Index
93
Citations
84243
World Ranking
945
National Ranking
467

Overview

Shamil R. Sunyaev is affiliated with Harvard University in the United States and works primarily in the fields of Biochemistry, Genetics and Molecular Biology. Their research output includes a significant focus on Genetics and Molecular Biology, with contributions also to Cancer Research, Physiology, and Neurology.

The scientist's work covers a range of topics, including:

  • Genomics and Rare Diseases
  • Genetic Associations and Epidemiology
  • Cancer Genomics and Diagnostics
  • Genomics and Phylogenetic Studies
  • Genomic Variations and Chromosomal Abnormalities
  • Genomics and Chromatin Dynamics
  • Genetic Mapping and Diversity in Plants and Animals

Shamil R. Sunyaev has frequently published in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Genetics
  • Science
  • Zenodo (CERN European Organization for Nuclear Research)
  • Nature Communications

Notable recent publications by Sunyaev include:

  • "A cross-disorder dosage sensitivity map of the human genome," 2022, published in Cell
  • "Identification of cancer driver genes based on nucleotide context," 2020, published in Nature Genetics
  • "The landscape of tolerated genetic variation in humans and primates," 2023, published in Science
  • "The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability," 2022, published in Cell
  • "The missing link between genetic association and regulatory function," 2022, published in eLife

Frequent collaborators with Sunyaev include Evan Koch, Benjamin M. Neale, Vladimir B. Seplyarskiy, Daniel J. Balick, and Sumaiya Nazeen. These collaborations are reflected in multiple joint publications.

Best Publications

  • A method and server for predicting damaging missense mutations.

    Ivan A Adzhubei;Steffen Schmidt;Leonid Peshkin;Vasily E Ramensky

  • Integrative analysis of 111 reference human epigenomes

    Anshul Kundaje;Wouter Meuleman;Wouter Meuleman;Jason Ernst

  • Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

    Ewan Birney;John A. Stamatoyannopoulos;Anindya Dutta;Roderic Guigó

  • Mutational heterogeneity in cancer and the search for new cancer-associated genes

    Michael S. Lawrence;Petar Stojanov;Petar Stojanov;Paz Polak;Paz Polak;Paz Polak;Gregory V. Kryukov;Gregory V. Kryukov;Gregory V. Kryukov

  • Systematic localization of common disease-associated variation in regulatory DNA.

    Matthew T. Maurano;Richard Humbert;Eric Rynes;Robert E. Thurman

  • Predicting Functional Effect of Human Missense Mutations Using PolyPhen-2

    Ivan Adzhubei;Daniel M. Jordan;Daniel M. Jordan;Shamil R. Sunyaev

  • The accessible chromatin landscape of the human genome

    Robert E. Thurman;Eric Rynes;Richard Humbert;Jeff Vierstra

  • Human non‐synonymous SNPs: server and survey

    Vasily Ramensky;Peer Bork;Shamil Sunyaev

  • Patterns and rates of exonic de novo mutations in autism spectrum disorders

    Benjamin M. Neale;Yan Kou;Li Liu;Avi Ma'Ayan

  • The mystery of missing heritability: Genetic interactions create phantom heritability.

    Or Zuk;Eliana Hechter;Shamil R. Sunyaev;Eric S. Lander

  • Evolution and functional impact of rare coding variation from deep sequencing of human exomes

    Jacob A. Tennessen;Abigail W. Bigham;Timothy D. O'Connor;Wenqing Fu

  • Guidelines for investigating causality of sequence variants in human disease

    D G MacArthur;T A Manolio;D P Dimmock;H L Rehm

  • Prediction of deleterious human alleles

    Shamil Sunyaev;Vasily Ramensky;Ina Koch;Warren Lathe

  • Genomic variation landscape of the human gut microbiome

    Siegfried Schloissnig;Manimozhiyan Arumugam;Shinichi Sunagawa;Makedonka Mitreva

  • Pooled Association Tests for Rare Variants in Exon-Resequencing Studies

    Alkes L. Price;Gregory V. Kryukov;Gregory V. Kryukov;Paul I.W. de Bakker;Paul I.W. de Bakker;Shaun M. Purcell;Shaun M. Purcell

  • Charting the Proteomes of Organisms with Unsequenced Genomes by MALDI-Quadrupole Time-of-Flight Mass Spectrometry and BLAST Homology Searching

    Shevchenko A;Sunyaev S;Loboda A;Bork P

  • Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction

    Ron Do;Ron Do;Nathan O. Stitziel;Hong Hee Won;Hong Hee Won;Anders Berg Jørgensen

  • Assessing the Evolutionary Impact of Amino Acid Mutations in the Human Genome

    Adam R. Boyko;Scott H. Williamson;Amit R. Indap;Jeremiah D. Degenhardt

  • Searching for missing heritability: Designing rare variant association studies

    Or Zuk;Or Zuk;Stephen F. Schaffner;Kaitlin Samocha;Ron Do

  • Most Rare Missense Alleles Are Deleterious in Humans: Implications for Complex Disease and Association Studies

    Gregory V. Kryukov;Len A. Pennacchio;Len A. Pennacchio;Shamil R. Sunyaev

Frequent Co-Authors

Peer Bork
Peer Bork European Molecular Biology Laboratory
Paul I. W. de Bakker
Paul I. W. de Bakker Vertex Pharmaceuticals (United Kingdom)
Gregory V. Kryukov
Gregory V. Kryukov Broad Institute
Benjamin M. Neale
Benjamin M. Neale Harvard University
Alkes L. Price
Alkes L. Price Harvard University
Ron Do
Ron Do Icahn School of Medicine at Mount Sinai
David Reich
David Reich Harvard Medical School
Susan Redline
Susan Redline Brigham and Women's Hospital
John A. Stamatoyannopoulos
John A. Stamatoyannopoulos University of Washington
Mark J. Daly
Mark J. Daly Massachusetts General Hospital

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