What is she best known for?
The fields of study she is best known for:
Her primary scientific interests are in Biochemistry, Palmitoyl protein thioesterase, PPT1, Infantile neuronal ceroid lipofuscinosis and CLN8.
Her Palmitoyl protein thioesterase study incorporates themes from Heterotrimeric G protein, Palmitoyl hydrolase and Molecular biology.
Sandra L. Hofmann has included themes like DNA footprinting, Psychological repression, Sp1 transcription factor and Binding site in her Molecular biology study.
Her Infantile neuronal ceroid lipofuscinosis study is concerned with the larger field of Neuronal ceroid lipofuscinosis.
Sandra L. Hofmann interconnects Cerebellum, Neuroscience, Neuropathology and Astrocytosis in the investigation of issues within Neuronal ceroid lipofuscinosis.
Her work on Missense mutation and Nonsense mutation is typically connected to Population as part of general Genetics study, connecting several disciplines of science.
Her most cited work include:
- Mutations in the palmitoyl protein thioesterase gene causing infantile neuronal ceroid lipofuscinosis (611 citations)
- Purification and properties of a palmitoyl-protein thioesterase that cleaves palmitate from H-Ras. (287 citations)
- Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in knockout mice (249 citations)
What are the main themes of her work throughout her whole career to date?
Her primary areas of study are Biochemistry, Palmitoyl protein thioesterase, Infantile neuronal ceroid lipofuscinosis, PPT1 and Neuronal ceroid lipofuscinosis.
The various areas that Sandra L. Hofmann examines in her Palmitoyl protein thioesterase study include Molecular genetics, Molecular biology and Stereochemistry.
Her biological study spans a wide range of topics, including Lipid metabolism, Mannose 6-phosphate receptor and Intracellular.
Her study deals with a combination of PPT1 and CLN8.
Her research integrates issues of Batten disease, Lysosomal storage disease, Nonsense mutation and Bioinformatics in her study of Neuronal ceroid lipofuscinosis.
The study incorporates disciplines such as Endocrinology, Neurodegeneration, Neuroscience and Enzyme replacement therapy in addition to Batten disease.
She most often published in these fields:
- Biochemistry (43.00%)
- Palmitoyl protein thioesterase (41.00%)
- Infantile neuronal ceroid lipofuscinosis (30.00%)
What were the highlights of her more recent work (between 2014-2020)?
- Enzyme replacement therapy (7.00%)
- Internal medicine (14.00%)
- Surgery (4.00%)
In recent papers she was focusing on the following fields of study:
The scientist’s investigation covers issues in Enzyme replacement therapy, Internal medicine, Surgery, Biochemistry and Cell growth.
Her Enzyme replacement therapy study integrates concerns from other disciplines, such as Batten disease, PPT1, Palmitoyl protein thioesterase and Spinal cord.
Her Batten disease research includes themes of Neuronal ceroid lipofuscinosis and Infantile neuronal ceroid lipofuscinosis.
Her Infantile neuronal ceroid lipofuscinosis research is multidisciplinary, incorporating elements of Wild type and Genetic enhancement.
Within one scientific family, Sandra L. Hofmann focuses on topics pertaining to Gastroenterology under Internal medicine, and may sometimes address concerns connected to Thrombotic thrombocytopenic purpura, Baseline risk and Low dose.
Sandra L. Hofmann is studying Signal transduction, which is a component of Biochemistry.
Between 2014 and 2020, her most popular works were:
- Experimental therapies in the neuronal ceroid lipofuscinoses (25 citations)
- Intrathecal enzyme replacement therapy improves motor function and survival in a preclinical mouse model of infantile neuronal ceroid lipofuscinosis (24 citations)
- Systematic siRNA screen unmasks NSCLC growth dependence by palmitoyltransferase DHHC5 (18 citations)
In her most recent research, the most cited papers focused on:
Sandra L. Hofmann mainly focuses on Enzyme replacement therapy, Palmitoyl protein thioesterase, PPT1, Neuronal ceroid lipofuscinosis and Batten disease.
Her Palmitoyl protein thioesterase study is focused on Biochemistry in general.
Her study in PPT1 is interdisciplinary in nature, drawing from both Spinal cord, Central nervous system and Infantile neuronal ceroid lipofuscinosis.
Her Neuronal ceroid lipofuscinosis study incorporates themes from Neurodegeneration and Bioinformatics.
Her Batten disease research integrates issues from Endocrinology and Clinical trial.
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