J. William Lown

Overview

Best Publications

• Strand scission of DNA by bound adriamycin and daunorubicin in the presence of reducing agents.

  J. William Lown;Soo-Khoon Sim;Krishna C. Majumdar;Rwei-Ying Chang

  366
  Citations

• The mechanism of the bleomycin-induced cleavage of DNA.

  J. William Lown;Soo-Khoon Sim

  349
  Citations

• Hypocrellins and their use in photosensitization.

  Diwu Zhenjun;J. William Lown

  300
  Citations

• Synthetic DNA minor groove-binding drugs.

  B.S.Praveen Reddy;S.Murari Sondhi;J.William Lown

  296
  Citations

• Molecular recognition between oligopeptides and nucleic acids: novel imidazole-containing oligopeptides related to netropsin that exhibit altered DNA sequence specificity.

  Lown Jw;Krowicki K;Bhat Ug;Skorobogaty A

  267
  Citations

• Photosensitization by anticancer agents 12. Perylene quinonoid pigments, a novel type of singlet oxygen sensitizer

  Zhenjun Diwu;J.William Lown

  248
  Citations

• Anthracycline and anthraquinone anticancer agents: Current status and recent developments

  J. William Lown

  243
  Citations

• Phototherapeutic potential of alternative photosensitizers to porphyrins

  Zhenjun Diwu;J. William Lown

  202
  Citations

• Anticancer, Anti-inflammatory and Analgesic Activity Evaluation of Heterocyclic Compounds Synthesized by the Reaction of 4-Isothiocyanato-4-methylpentan-2-one with Substituted o-Phenylenediamines, o-Diaminopyridine and (Un)Substituted o

  Sham M. Sondhi;Monika Johar;Shefali Rajvanshi;Sunanda G. Dastidar

  184
  Citations

• Electrochemical Studies of Antitumor Antibiotics III . Daunorubicin and Adriamycin

  Gopalakrishna M. Rao;J. William Lown;James A. Plambeck

  173
  Citations

• Molecular mechanisms of binding and single-strand scission of DNA by the antitumor antibiotics saframycins A and C

  J. William Lown;Alummoottil V. Joshua;Jeremy S. Lee

  171
  Citations

• Molecular recognition between oligopeptides and nucleic acids. Monocationic imidazole lexitropsins that display enhanced GC sequence dependent DNA binding.

  Koren Kissinger;Krzysztof Krowicki;James C. Dabrowiak;J. William Lown

  171
  Citations

• Further studies on the generation of reactive oxygen species from activated anthracyclines and the relationship to cytotoxic action and cardiotoxic effects.

  J. William Lown;Hsiao-Hsiung Chen;James A. Plambeck;Edward M. Acton

  163
  Citations

• The mechanism of action of quinone antibiotics.

  J. William Lown

  159
  Citations

• Preclinical Assessment of Hypocrellin B and Hypocrellin B Derivatives as Sensitizers for Photodynamic Therapy of Cancer: Progress Update

  Gerald G. Miller;Kevin Brown;Åse M. Ballangrud;Åse M. Ballangrud;Oscar Barajas

  148
  Citations

• Novel linked antiviral and antitumor agents related to netropsin and distamycin: synthesis and biological evaluation

  J W Lown;K Krowicki;J Balzarini;R A Newman

  146
  Citations

• Diminished superoxide anion generation by reduced 5-iminodaunorubicin relative to daunorubicin and the relationship to cardiotoxicity of the anthracycline antitumor agents.

  J.William Lown;Chen Hsiao-Hsiung;James A. Plambeck;Edward M. Acton

  144
  Citations

• Photosensitization with anticancer agents: 15. Perylenequinonoid pigments as potential photodynamic therapeutic agents: Formation of semiquinone radicals and reactive oxygen species on illumination

  Zhenjun Diwu;J.William Lown

  143
  Citations

• α-DNA I. Synthesis, characterization by high field 1H-NMR, and base-pairing properties of the unnatural hexadeoxyribonudeotide α-[d(CpCpTpTpCpC)] with its complement β-[d(GpGpApApGpG)]

  F Morvan;B Rayner;J L Imbach;D K Chang

  140
  Citations

• Hydroxyl radical production by free and DNA-bound aminoquinone antibiotics and its role in DNA degradation. Electron spin resonance detection of hydroxyl radicals by spin trapping.

  J. William Lown;Soo-Khoon Sim;Hsiao-Hsiung Chen

  135
  Citations

• Characteristics of the binding of the anticancer agents mitoxantrone and ametantrone and related structures to deoxyribonucleic acids.

  Unknown

  122
  Citations