Brian D. Palmer

Overview

Best Publications

• Mechanisms and biomaterials in pH-responsive tumour targeted drug delivery: A review.

  Manju Kanamala;William R. Wilson;Mimi Yang;Brian D. Palmer

  1004
  Citations

• Tyrosine kinase inhibitors. 15. 4-(Phenylamino)quinazoline and 4-(phenylamino)pyrido[d]pyrimidine acrylamides as irreversible inhibitors of the ATP binding site of the epidermal growth factor receptor.

  J. B. Smaill;B. D. Palmer;G. W. Rewcastle;W. A. Denny

  311
  Citations

• Hypoxia-selective antitumor agents. 7. Metal complexes of aliphatic mustards as a new class of hypoxia-selective cytotoxins. Synthesis and evaluation of cobalt(III) complexes of bidentate mustards.

  David C. Ware;Brian D. Palmer;William R. Wilson;William A. Denny

  266
  Citations

• Relationships Between Hydrophobicity, Reactivity, Accumulation And Peripheral Nerve Toxicity Of A Series Of Platinum Drugs

  D. Screnci;M.J. McKeage;P. Galettis;T.W. Hambley

  246
  Citations

• Tyrosine kinase inhibitors. 9. Synthesis and evaluation of fused tricyclic quinazoline analogues as ATP site inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor

  Gordon W. Rewcastle;Brian D. Palmer;Alexander J. Bridges;H. D. Hollis Showalter

  233
  Citations

• Tyrosine kinase inhibitors. 10. Isomeric 4-[(3-bromophenyl)amino]pyrido[d]-pyrimidines are potent ATP binding site inhibitors of the tyrosine kinase function of the epidermal growth factor receptor.

  Gordon W. Rewcastle;Brian D. Palmer;Andrew M. Thompson;Alexander J. Bridges

  204
  Citations

• Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells

  Leslie A. Parsels;Meredith A. Morgan;Daria M. Tanska;Joshua D. Parsels

  181
  Citations

• Tyrosine Kinase Inhibitors. 11. Soluble Analogues of Pyrrolo- and Pyrazoloquinazolines as Epidermal Growth Factor Receptor Inhibitors: Synthesis, Biological Evaluation, and Modeling of the Mode of Binding

  Brian D. Palmer;Susanne Trumpp-Kallmeyer;David W. Fry;James M. Nelson

  173
  Citations

• Hypoxia-selective antitumor agents. 3. Relationships between structure and cytotoxicity against cultured tumor cells for substituted N,N-bis(2-chloroethyl)anilines.

  Brian D. Palmer;William R. Wilson;Susan M. Pullen;William A. Denny

  161
  Citations

• Synthesis and Structure−Activity Relationships of Aza- and Diazabiphenyl Analogues of the Antitubercular Drug (6S)-2-Nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824)

  Iveta Kmentova;Hamish S. Sutherland;Brian D. Palmer;Adrian Blaser

  152
  Citations

• Synthesis and structure-activity studies of biphenyl analogues of the tuberculosis drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).

  Brian D. Palmer;Andrew M. Thompson;Hamish S. Sutherland;Adrian Blaser

  148
  Citations

• 4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitution.

  Brian D Palmer;Andrew M Thompson;R John Booth;Ellen M Dobrusin

  143
  Citations

• Bioactivation of dinitrobenzamide mustards by an E. coli B nitroreductase.

  G.M. Anlezark;R.G. Melton;R.F. Sherwood;W.R. Wilson

  139
  Citations

• Synthesis, reduction potentials, and antitubercular activity of ring A/B analogues of the bioreductive drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).

  Andrew M. Thompson;Adrian Blaser;Robert F. Anderson;Sujata S. Shinde

  133
  Citations

• Potential antitumor agents. 54. Chromophore requirements for in vivo antitumor activity among the general class of linear tricyclic carboxamides

  Brian D. Palmer;Gordon W. Rewcastle;Graham J. Atwell;Bruce C. Baguley

  124
  Citations

• Hypoxia-selective antitumor agents. 5. Synthesis of water-soluble nitroaniline mustards with selective cytotoxicity for hypoxic mammalian cells.

  Brian D. Palmer;William R. Wilson;Stephen Cliffe;William A. Denny

  115
  Citations

• Mustard prodrugs for activation by Escherichia coli nitroreductase in gene-directed enzyme prodrug therapy

  Frank Friedlos;William A. Denny;Brian D. Palmer;Caroline J. Springer

  113
  Citations

• DNA-directed alkylating agents. 5. Acridinecarboxamide derivatives of (1,2-diaminoethane)dichloroplatinum(II).

  Ho H. Lee;Brian D. Palmer;Bruce C. Baguley;Michael Chin

  109
  Citations

• Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1.

  Brian D. Palmer;Jeff B. Smaill;Gordon W. Rewcastle;Ellen M. Dobrusin

  108
  Citations

• Total synthesis of the ionophore antibiotic X-14547A (Indanomycin)

  Martin P. Edwards;Steven V. Ley;Simon G. Lister;Brian D. Palmer

  104
  Citations

• 3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel.

  Hamish S. Sutherland;Amy S.T. Tong;Peter J. Choi;Adrian Blaser

  103
  Citations