World's Best Scientists 2026 revealed!
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Biology and Biochemistry
Israel
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
104
Citations
38326
World Ranking
1258
National Ranking
9

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Israel Leader Award
  • 2025 - Research.com Biology and Biochemistry in Israel Leader Award

Overview

Alexander Levitzki is affiliated with the Hebrew University of Jerusalem in Israel. Their research primarily focuses on the fields of medicine and biochemistry, genetics, and molecular biology, with notable contributions to oncology, molecular biology, cancer research, radiology, nuclear medicine and imaging, and pulmonary and respiratory medicine.

The scientist's work centers around key topics including cancer immunotherapy and biomarkers, RNA modifications and cancer, cancer therapeutics and mechanisms, lung cancer treatments and mutations, cancer in relation to hypoxia and metabolism, cancer involving lipids and metabolism, and research on monoclonal and polyclonal antibodies.

Alexander Levitzki has published papers in venues such as Regular and Young Investigator Award Abstracts, Cancer Research, and bioRxiv (Cold Spring Harbor Laboratory). Their recent papers include:

  • "1170 EGFR-Ta:RNA: multimodal mechanism of action potentiates immune checkpoint inhibitor activity" (2022, Regular and Young Investigator Award Abstracts)
  • "Abstract 5799: Novel nanoparticle technology targets the delivery of polyIC to EGFR overexpressing cancers and induces a multimodal anti-tumor response" (2024, Cancer Research)
  • "1026 Novel targeted nanoparticles induce a multi-modal anti-tumor response in EGFR-overexpressing cancers" (2024, Regular and Young Investigator Award Abstracts)
  • "EGFR-targeted affibody-polyIC polyplex kills EGFR-overexpressing cancer cells without activating the EGFR" (2025, bioRxiv [Cold Spring Harbor Laboratory])

Their research involves collaborative work with frequent co-authors including Alexei Shir, Maya Zigler, Babette Schade, Derrick Broka, and Caroline De Feyter.

Best Publications

  • Tyrosine kinase inhibition: an approach to drug development

    Alexander Levitzki;Aviv Gazit

  • Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells

    Robyn Catlett-Falcone;Terry H Landowski;Marc M Oshiro;James Turkson

  • Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

    N Meydan;T Grunberger;H Dadi;M Shahar

  • Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells.

    Roy Garcia;Tammy L Bowman;Guilian Niu;Hua Yu

  • EGF induces tyrosine phosphorylation of phospholipase C-II: a potential mechanism for EGF receptor signaling.

    B. Margolis;S.G. Rhee;S. Felder;M. Mervic

  • Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors.

    Aviv Gazit;Pnina Yaish;Chaim Gilon;Alexander Levitzki

  • Blocking of EGF-Dependent Cell Proliferation by EGF Receptor Kinase Inhibitors

    Pnina Yaish;Aviv Gazit;Chaim Gilon;Alexander Levitzki

  • ROS, stress-activated kinases and stress signaling in cancer.

    Moran Benhar;David Engelberg;Alexander Levitzki

  • Transglutaminase is essential in receptor-mediated endocytosis of alpha 2-macroglobulin and polypeptide hormones.

    Peter J. A. Davies;Dana R. Davies;Alexander Levitzki;Alexander Levitzki;Frederick R. Maxfield

  • NEGATIVE COOPERATIVITY IN REGULATORY ENZYMES

    Alexander Levitzki;D. E. Koshland

  • Crystal Structure of Hck in Complex with a Src Family–Selective Tyrosine Kinase Inhibitor

    Thomas Schindler;Frank Sicheri;Alexander Pico;Aviv Gazit

  • Mode of coupling between the beta-adrenergic receptor and adenylate cyclase in turkey erythrocytes.

    Aviva M. Tolkovsky;Alexander Levitzki

  • Enhanced ROS Production in Oncogenically Transformed Cells Potentiates c-Jun N-Terminal Kinase and p38 Mitogen-Activated Protein Kinase Activation and Sensitization to Genotoxic Stress

    Moran Benhar;Idan Dalyot;David Engelberg;Alexander Levitzki

  • Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteases.

    M. Nagane;A. Levitzki;A. Gazit;W. K. Cavenee

  • Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors

    Abraham Novogrodsky;Alexey Vanichkin;Miriam Patya;Aviv Gazit

  • Tyrphostins: tyrosine kinase blockers as novel antiproliferative agents and dissectors of signal transduction.

    Alexander Levitzki

  • Metal-binding sites of concanavalin A and their role in the binding of α-methyl d-glucopyranoside

    A. Joseph Kalb;Alexander Levitzki

  • The effect of tyrosine-specific protein phosphorylation on the assembly of adherens-type junctions.

    T Volberg;Y Zick;R Dror;I Sabanay

  • From epinephrine to cyclic AMP.

    Alexander Levitzki

  • Epidermal-growth-factor-dependent activation of the src-family kinases.

    Nir Osherov;Alexander Levitzki

Frequent Co-Authors

Chaim Gilon
Chaim Gilon Hebrew University of Jerusalem
Michael L. Steer
Michael L. Steer Harvard University
Daphne Atlas
Daphne Atlas Hebrew University of Jerusalem
Michael Chorev
Michael Chorev Harvard University
Yoav I. Henis
Yoav I. Henis Tel Aviv University
Antony W. Burgess
Antony W. Burgess Walter and Eliza Hall Institute of Medical Research
Daniel E. Koshland
Daniel E. Koshland University of California, Berkeley
Johannes Waltenberger
Johannes Waltenberger University of Münster
Giora Simchen
Giora Simchen Hebrew University of Jerusalem
Richard Jove
Richard Jove Nova Southeastern University

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