World's Best Scientists 2026 revealed!
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Chemistry
New Zealand
2026

D-Index & Metrics

Chemistry

D-Index
71
Citations
14708
World Ranking
5692
National Ranking
8

Research.com Recognitions

  • 2026 - Research.com Chemistry in New Zealand Leader Award
  • 2025 - Research.com Chemistry in New Zealand Leader Award
  • 2022 - Research.com Chemistry in New Zealand Leader Award

Overview

William R. Wilson is affiliated with the University of Auckland in New Zealand. Their research spans several areas within the broader fields of biochemistry, genetics, molecular biology, and medicine.

The scientist's work concentrates on molecular biology, cancer research, oncology, genetics, and pulmonary and respiratory medicine as key subfields of study. Their main topics of research include:

  • Cancer, Hypoxia, and Metabolism
  • Epigenetics and DNA Methylation
  • RNA modifications and cancer
  • Cancer Research and Treatments
  • Nanoplatforms for cancer theranostics
  • CAR-T cell therapy research
  • Autophagy in Disease and Therapy

Wilson has published frequently in venues such as:

  • Journal of Crohn's and Colitis
  • Cancer Research
  • Cancer Gene Therapy
  • European Journal of Cancer
  • Nature Reviews Clinical Oncology

Recent papers authored or co-authored by William R. Wilson include:

  • Therapeutic targeting of the hypoxic tumour microenvironment, 2021, Nature Reviews Clinical Oncology
  • Radiosensitisation of SCCVII tumours and normal tissues in mice by the DNA-dependent protein kinase inhibitor AZD7648, 2021, Radiotherapy and Oncology
  • Calcium Enabled Remote Loading of a Weak Acid Into pH-sensitive Liposomes and Augmented Cytosolic Delivery to Cancer Cells via the Proton Sponge Effect, 2022, Pharmaceutical Research
  • Bioreductive prodrug PR-104 improves the tumour distribution and titre of the nitroreductase-armed oncolytic adenovirus ONYX-411NTR leading to therapeutic benefit, 2021, Cancer Gene Therapy
  • Subcellular Location of Tirapazamine Reduction Dramatically Affects Aerobic but Not Anoxic Cytotoxicity, 2020, Molecules

Frequent collaborators with whom Wilson has authored multiple papers include:

  • Stephen M. F. Jamieson
  • Michael P. Hay
  • Cho Rong Hong
  • Way W. Wong
  • Benjamin D. Dickson

Best Publications

  • Mechanisms and biomaterials in pH-responsive tumour targeted drug delivery: A review.

    Manju Kanamala;William R. Wilson;Mimi Yang;Brian D. Palmer

  • Therapeutic targeting of the hypoxic tumour microenvironment.

    Dean C Singleton;Andrew Macann;William R Wilson

  • A semiautomated microculture method for investigating growth inhibitory effects of cytotoxic compounds on exponentially growing carcinoma cells

    Graeme J. Finlay;Bruce C. Baguley;William R. Wilson

  • Hypoxia-selective antitumor agents. 7. Metal complexes of aliphatic mustards as a new class of hypoxia-selective cytotoxins. Synthesis and evaluation of cobalt(III) complexes of bidentate mustards.

    David C. Ware;Brian D. Palmer;William R. Wilson;William A. Denny

  • DNA-Directed Alkylating Agents. 6. Synthesis and Antitumor Activity of DNA Minor Groove-Targeted Aniline Mustard Analogs of Pibenzimol (Hoechst 33258)

    Gravatt Gl;Baguley Bc;Wilson Wr;Denny Wa

  • Blood Flow Failure as a Major Determinant in the Antitumor Action of Flavone Acetic Acid

    L. Jonathan Zwi;Bruce C. Baguley;John B. Gavin;William R. Wilson

  • Considerations for the design of nitrophenyl mustards as agents with selective toxicity for hypoxic tumor cells.

    William A. Denny;William R. Wilson

  • Hypoxia-selective antitumor agents. 3. Relationships between structure and cytotoxicity against cultured tumor cells for substituted N,N-bis(2-chloroethyl)anilines.

    Brian D. Palmer;William R. Wilson;Susan M. Pullen;William A. Denny

  • Enhancement of the anti-tumour effects of the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) by combination with 5-hydroxytryptamine and bioreductive drugs

    C J Lash;A E Li;M Rutland;B C Baguley

  • Pharmacokinetic/Pharmacodynamic Modeling Identifies SN30000 and SN29751 as Tirapazamine Analogues with Improved Tissue Penetration and Hypoxic Cell Killing in Tumors

    Kevin O. Hicks;Bronwyn G. Siim;Jagdish K. Jaiswal;Frederik B. Pruijn

  • Multicellular resistance to tirapazamine is due to restricted extravascular transport: a pharmacokinetic/pharmacodynamic study in HT29 multicellular layer cultures.

    Kevin O Hicks;Frederik B Pruijn;Joanna R Sturman;William A Denny

  • Structure−Activity Relationships of 1,2,4-Benzotriazine 1,4-Dioxides as Hypoxia-Selective Analogues of Tirapazamine

    Michael P Hay;Swarna A Gamage;Mary S Kovacs;Frederik B Pruijn

  • Recent developments in the design of bioreductive drugs.

    W. A. Denny;W. R. Wilson;M. P. Hay

  • A 2-nitroimidazole carbamate prodrug of 5-amino-1-(chloromethyl)-3-[(5,6,7-trimethoxyindol-2-yl)carbonyl]-1,2-dihydro-3H-benz[e]indole (amino-seco-CBI-TMI) for use with ADEPT and GDEPT

    Michael P. Hay;Bridget M. Sykes;William A. Denny;William R. Wilson

  • Interaction of the antitumor drug 4'-(9-acridinylamino)methanesulfon-m-anisidide and related acridines with nucleic acids.

    William R. Wilson;Bruce C. Baguley;Laurence P. G. Wakelin;Michael J. Waring

  • Marked potentiation of the antitumour activity of chemotherapeutic drugs by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA)

    Bronwyn G. Siim;Alan E. Lee;Sahar Shalal-Zwain;Frederik B. Pruijn

  • Bioactivation of dinitrobenzamide mustards by an E. coli B nitroreductase.

    G.M. Anlezark;R.G. Melton;R.F. Sherwood;W.R. Wilson

  • Unsymmetrical DNA Cross-Linking Agents: Combination of the CBI and PBD Pharmacophores

    Moana Tercel;Stephen M Stribbling;Hilary Sheppard;Bronwyn G Siim

  • Combination therapy for cancer

    William R. Wilson

  • Tirapazamine: a bioreductive anticancer drug that exploits tumour hypoxia

    William A Denny;William R Wilson

  • DNA-directed alkylating agents. 1. Structure-activity relationships for acridine-linked aniline mustards: consequences of varying the reactivity of the mustard.

    T. A. Gourdie;K. K. Valu;G. L. Gravatt;T. J. Boritzki

  • Discovery and evaluation of Escherichia coli nitroreductases that activate the anti-cancer prodrug CB1954

    GA Prosser;JN Copp;SP Syddall;EM Williams

Frequent Co-Authors

William A. Denny
William A. Denny University of Auckland
Bruce C. Baguley
Bruce C. Baguley University of Auckland
Brian D. Palmer
Brian D. Palmer University of Auckland
Marina Konopleva
Marina Konopleva The University of Texas MD Anderson Cancer Center
J. Martin Brown
J. Martin Brown Stanford University
Cristin G. Print
Cristin G. Print University of Auckland
Hagop M. Kantarjian
Hagop M. Kantarjian The University of Texas MD Anderson Cancer Center
Gautam Borthakur
Gautam Borthakur The University of Texas MD Anderson Cancer Center
Bradly G. Wouters
Bradly G. Wouters Princess Margaret Cancer Centre
Deborah A. Thomas
Deborah A. Thomas The University of Texas MD Anderson Cancer Center

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