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Trevor W. Hambley

Trevor W. Hambley

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Chemistry
Australia
2025

D-Index & Metrics

Chemistry

D-Index
81
Citations
24235
World Ranking
3235
National Ranking
88

Research.com Recognitions

  • 2025 - Research.com Chemistry in Australia Leader Award
  • 2022 - Research.com Chemistry in Australia Leader Award
  • 2011 - Fellow of the Australian Academy of Science

Overview

Trevor W. Hambley is affiliated with the University of Sydney in Australia, with a research focus spanning multiple disciplines within Materials Science, Biochemistry, Genetics and Molecular Biology, and Medicine. The scientist's work mainly concentrates on Materials Chemistry, Oncology, Molecular Biology, Organic Chemistry, and Physical and Theoretical Chemistry.

Hambley's research investigates various aspects of metal complexes synthesis and properties, enzyme structure and function, ferrocene chemistry and applications, lanthanide and transition metal complexes, as well as DNA and nucleic acid chemistry. Additional areas of interest include crystallization and solubility studies, and X-ray diffraction in crystallography.

The following recent papers illustrate the scope and direction of Hambley's scholarly output:

  • trans-Platinum(iv) pro-drugs that exhibit unusual resistance to reduction by endogenous reductants and blood serum but are rapidly activated inside cells: 1H NMR and XANES spectroscopy study, 2020, Dalton Transactions
  • Warburg Effect Targeting Co(III) Cytotoxin Chaperone Complexes, 2021, Journal of Medicinal Chemistry
  • Water-Soluble α-Amino Acid Complexes of Molybdenum as Potential Antidotes for Cyanide Poisoning: Synthesis and Catalytic Studies of Threonine, Methionine, Serine, and Leucine Complexes, 2020, Inorganic Chemistry
  • The effect of charge on the uptake and resistance to reduction of platinum(iv) complexes in human serum and whole blood models, 2020, Metallomics
  • Novel polyamide amidine anthraquinone platinum(II) complexes: cytotoxicity, cellular accumulation, and fluorescence distributions in 2D and 3D cell culture models, 2021, JBIC Journal of Biological Inorganic Chemistry

Frequent publication venues for Hambley include:

  • Dalton Transactions
  • The Cambridge Structural Database
  • Journal of Medicinal Chemistry
  • Inorganic Chemistry
  • Metallomics

Among frequent co-authors collaborating with Hambley are Catherine K. J. Chen, Johanna M. Gretarsdóttir, William Lewis, Sigrídur G. Suman, and Peter Kappen.

Hambley's contributions to science have been recognized through their election as a Fellow of the Australian Academy of Science in 2011.

Best Publications

  • Part I. Theory

    Peter Comba;Trevor W. Hambley

  • Platinum(IV) antitumour compounds: their bioinorganic chemistry

    Matthew D. Hall;Trevor W. Hambley

  • The Discovery and Development of Cisplatin

    Rebecca A. Alderden;Matthew D. Hall;Trevor W. Hambley

  • Copper complexes of non-steroidal anti-inflammatory drugs: an opportunity yet to be realized

    Jane E. Weder;Carolyn T. Dillon;Trevor W. Hambley;Brendan J. Kennedy

  • Basis for design and development of platinum(IV) anticancer complexes.

    Matthew D Hall;Howard R Mellor;Richard Callaghan;Trevor W Hambley

  • Molecular modeling of inorganic compounds

    Peter Comba;Trevor W. Hambley

  • The influence of structure on the activity and toxicity of Pt anti-cancer drugs

    Trevor W. Hambley

  • Platinum drug distribution in cancer cells and tumors.

    Alice V Klein;Trevor W Hambley

  • Developing new metal-based therapeutics: challenges and opportunities.

    Trevor W. Hambley

  • A 1H NMR Study of the DNA Binding of Ruthenium(II) Polypyridyl Complexes

    J. Grant Collins;Andrew D. Sleeman;Janice R. Aldrich-Wright, ,‡;and Ivan Greguric

  • Metal-Based Therapeutics

    Trevor W. Hambley

  • Metal ion encapsulation: cobalt cages derived from polyamines, formaldehyde, and nitromethane

    R. J. Geue;T. W. Hambley;J. M. Harrowfield;A. M. Sargeson

  • Relationships Between Hydrophobicity, Reactivity, Accumulation And Peripheral Nerve Toxicity Of A Series Of Platinum Drugs

    D. Screnci;M.J. McKeage;P. Galettis;T.W. Hambley

  • Bioreductive activation and drug chaperoning in cobalt pharmaceuticals

    Matthew D. Hall;Matthew D. Hall;Timothy W. Failes;Natsuho Yamamoto;Trevor W. Hambley

  • Pt(IV) analogs of oxaliplatin that do not follow the expected correlation between electrochemical reduction potential and rate of reduction by ascorbate

    Jenny Z. Zhang;Ezequiel Wexselblatt;Trevor W. Hambley;Dan Gibson

  • Syntheses and characterization of anti-inflammatory dinuclear and mononuclear zinc indomethacin complexes. Crystal structures of [Zn2(indomethacin)4(L)2] (L = N,N-dimethylacetamide, pyridine, 1-methyl-2-pyrrolidinone) and [Zn(indomethacin)2(L1)2] (L1 = ethanol, methanol).

    Zhou Q;Hambley Tw;Kennedy Bj;Lay Pa

  • The Influence of the Axial Ligands of a Series of Platinum(IV) Anti-Cancer Complexes on Their Reduction to Platinum(II) and Reaction With DNA

    L. T. Ellis;Hui Meng Er;T. W. Hambley

  • Is anticancer drug development heading in the right direction

    Trevor W. Hambley;William N. Hait

  • Slowing of cisplatin aquation in the presence of DNA but not in the presence of phosphate: improved understanding of sequence selectivity and the roles of monoaquated and diaquated species in the binding of cisplatin to DNA.

    Murray S. Davies;Susan J. Berners-Price;Trevor W. Hambley

  • Immobilization of Platinated and Iodinated Oligonucleotides on Carbon Nanotubes

    Shik Chi Tsang;Zijian Guo;Yao Kuan Chen;Malcolm L. H. Green

Frequent Co-Authors

Leslie D. Field
Leslie D. Field University of New South Wales
Peter Comba
Peter Comba Heidelberg University
Geoffrey A. Lawrance
Geoffrey A. Lawrance University of Newcastle Australia
Lawrence R. Gahan
Lawrence R. Gahan University of Queensland
Peter A. Lay
Peter A. Lay University of Sydney
Matthew D. Hall
Matthew D. Hall National Institutes of Health
Paul V. Bernhardt
Paul V. Bernhardt University of Queensland
Marcel Maeder
Marcel Maeder University of Newcastle Australia
Graeme R. Hanson
Graeme R. Hanson University of Queensland
Brendan J. Kennedy
Brendan J. Kennedy University of Sydney

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