David W. Fry

Overview

Best Publications

• A specific inhibitor of the epidermal growth factor receptor tyrosine kinase

  David W. Fry;Alan J. Kraker;Amy McMichael;Linda A. Ambroso

  1235
  Citations

• Irreversible inhibitors of tyrosine kinases

  Alexander James Bridges;William Alexander Denny;Ellen Myra Dobrusin;Annette Marian Doherty

  726
  Citations

• Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2.

  James D. Owen;Paul J. Ruest;David W. Fry;Steven K. Hanks

  575
  Citations

• Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor

  David W. Fry;Alexander J. Bridges;William A. Denny;Annette Doherty

  573
  Citations

• Tyrosine Kinase Inhibitors. 8. An Unusually Steep Structure−Activity Relationship for Analogues of 4-(3-Bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a Potent Inhibitor of the Epidermal Growth Factor Receptor

  Alexander J. Bridges;Hairong Zhou;Donna R. Cody;Gordon W. Rewcastle

  524
  Citations

• Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family

  Alexander James Bridges;William Alexander Denny;David Fry;Alan Kraker

  510
  Citations

• Tyrosine kinase inhibitors. 5. Synthesis and structure-activity relationships for 4-[(phenylmethyl)amino]- and 4-(phenylamino)quinazolines as potent adenosine 5'-triphosphate binding site inhibitors of the tyrosine kinase domain of the epidermal growth factor receptor.

  Gordon W. Rewcastle;William A. Denny;Alexander J. Bridges;Hairong Zhou

  415
  Citations

• Antitumor activity and pharmacokinetic properties of PF-00299804, a second-generation irreversible pan-erbB receptor tyrosine kinase inhibitor

  Andrea J. Gonzales;Kenneth E. Hook;Irene W. Althaus;Paul A. Ellis

  315
  Citations

• Tyrosine kinase inhibitors. 15. 4-(Phenylamino)quinazoline and 4-(phenylamino)pyrido[d]pyrimidine acrylamides as irreversible inhibitors of the ATP binding site of the epidermal growth factor receptor.

  J. B. Smaill;B. D. Palmer;G. W. Rewcastle;W. A. Denny

  311
  Citations

• Pyrido 2,3-d] pyrimidines and 4-aminopyrimidines as inhibitors of cellular proliferation

  Diane Harris Boschelli;Ellen Myra Dobrusin;Annette Marian Doherty;Ali Fattaey

  280
  Citations

• Drug‐induced ubiquitylation and degradation of ErbB receptor tyrosine kinases: implications for cancer therapy

  Ami Citri;Iris Alroy;Sara Lavi;Chanan Rubin

  265
  Citations

• Structure−Activity Relationships for a Novel Series of Pyrido[2,3-d]pyrimidine Tyrosine Kinase Inhibitors

  James M. Hamby;Cleo J. C. Connolly;Mel C. Schroeder;R. Thomas Winters

  262
  Citations

• Pyrido[2,3-d]pyrimidin-7-ones as specific inhibitors of cyclin-dependent kinase 4.

  Scott N. Vanderwel;Patricia J. Harvey;Dennis J. Mcnamara;Joseph T. Repine

  245
  Citations

• Tyrosine kinase inhibitors. 9. Synthesis and evaluation of fused tricyclic quinazoline analogues as ATP site inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor

  Gordon W. Rewcastle;Brian D. Palmer;Alexander J. Bridges;H. D. Hollis Showalter

  233
  Citations

• Role of tyrosine kinase activity of epidermal growth factor receptor in the lysophosphatidic acid-stimulated mitogen-activated protein kinase pathway.

  Jess M. Cunnick;Jay F. Dorsey;Todd Standley;James Turkson

  216
  Citations

• Tyrosine kinase inhibitors. 7. 7-Amino-4-(phenylamino)- and 7-amino-4-[(phenylmethyl)amino]pyrido[4,3-d]pyrimidines: a new class of inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor.

  Andrew M. Thompson;Alexander J. Bridges;David W. Fry;Alan J. Kraker

  208
  Citations

• Inhibition of the epidermal growth factor receptor family of tyrosine kinases as an approach to cancer chemotherapy: progression from reversible to irreversible inhibitors.

  David W. Fry

  207
  Citations

• Tyrosine kinase inhibitors. 10. Isomeric 4-[(3-bromophenyl)amino]pyrido[d]-pyrimidines are potent ATP binding site inhibitors of the tyrosine kinase function of the epidermal growth factor receptor.

  Gordon W. Rewcastle;Brian D. Palmer;Andrew M. Thompson;Alexander J. Bridges

  204
  Citations

• Tyrosine kinase inhibitors. 16. 6,5,6-tricyclic benzothieno[3, 2-d]pyrimidines and pyrimido[5,4-b-] and -[4,5-b]ĭndoles as potent inhibitors of the epidermal growth factor receptor tyrosine kinase.

  H. D. Hollis Showalter;Alexander J. Bridges;Hairong Zhou;Anthony D. Sercel

  197
  Citations

• Inhibitors of tyrosine kinase.

  Wayne D. Klohs;David W. Fry;Alan J. Kraker

  187
  Citations