D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Medicine D-index 101 Citations 40,134 281 World Ranking 3550 National Ranking 2020

Research.com Recognitions

Awards & Achievements

2011 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

What is he best known for?

The fields of study he is best known for:

  • Internal medicine
  • Gene
  • Immune system

His main research concerns Endocrinology, Internal medicine, Immunology, Proinflammatory cytokine and Cytokine. His Endocrinology study integrates concerns from other disciplines, such as Antagonist and Receptor antagonist. His Internal medicine research includes elements of Macrophage and In vivo.

His work deals with themes such as Kynurenine and Indoleamine 2,3-dioxygenase, which intersect with Immunology. His work carried out in the field of Proinflammatory cytokine brings together such families of science as Interleukin 10, Psychoneuroimmunology, Cytokine receptor and MAPK/ERK pathway. His studies in Cytokine integrate themes in fields like Central nervous system, Recombinant DNA, Vagus nerve and Ratón.

His most cited work include:

  • From inflammation to sickness and depression: when the immune system subjugates the brain (4269 citations)
  • Twenty years of research on cytokine-induced sickness behavior (939 citations)
  • Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice (786 citations)

What are the main themes of his work throughout his whole career to date?

The scientist’s investigation covers issues in Internal medicine, Endocrinology, Immunology, Cytokine and Immune system. His Internal medicine research is multidisciplinary, relying on both Concanavalin A and In vivo. His biological study spans a wide range of topics, including Interleukin and Receptor, Growth factor.

His Immunology research integrates issues from Kynurenine and Indoleamine 2,3-dioxygenase. In his study, Molecular biology is strongly linked to Tumor necrosis factor alpha, which falls under the umbrella field of Cytokine. His research in Immune system intersects with topics in Hormone, Antibody and Neuroscience.

He most often published in these fields:

  • Internal medicine (44.53%)
  • Endocrinology (44.27%)
  • Immunology (27.60%)

What were the highlights of his more recent work (between 2011-2021)?

  • Internal medicine (44.53%)
  • Endocrinology (44.27%)
  • Immunology (27.60%)

In recent papers he was focusing on the following fields of study:

His primary areas of study are Internal medicine, Endocrinology, Immunology, Inflammation and Immune system. Keith W. Kelley interconnects Gerontology and Function in the investigation of issues within Internal medicine. The study incorporates disciplines such as Cognition and Kynurenine in addition to Endocrinology.

He has included themes like Neurotrophin and Insulin-like growth factor in his Immunology study. His Immune system study integrates concerns from other disciplines, such as Porcine reproductive and respiratory syndrome virus, Microglia, Andrology, Signal transduction and Neuroscience. His work carried out in the field of Sickness behavior brings together such families of science as Proinflammatory cytokine, Spleen and Physiology.

Between 2011 and 2021, his most popular works were:

  • NMDA receptor blockade by ketamine abrogates lipopolysaccharide-induced depressive-like behavior in C57BL/6J mice (258 citations)
  • Immune–neural connections: how the immune system’s response to infectious agents influences behavior (252 citations)
  • Indoleamine 2,3-dioxygenase inhibition attenuates lipopolysaccharide induced persistent microglial activation and depressive-like complications in fractalkine receptor (CX3CR1)-deficient mice (102 citations)

In his most recent research, the most cited papers focused on:

  • Internal medicine
  • Gene
  • Enzyme

Keith W. Kelley mostly deals with Internal medicine, Endocrinology, Immunology, Kynurenine and Inflammation. Keith W. Kelley combines topics linked to Indoleamine 2,3-dioxygenase with his work on Internal medicine. His work deals with themes such as Receptor and Neuroinflammation, which intersect with Endocrinology.

His study in Sickness behavior, Immune system and Cytokine falls under the purview of Immunology. The concepts of his Sickness behavior study are interwoven with issues in Proinflammatory cytokine, Spleen and Innate immune system. His studies deal with areas such as NMDA receptor, NBQX, Receptor antagonist and Agonist as well as Kynurenine.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

From inflammation to sickness and depression: when the immune system subjugates the brain

Robert Dantzer;Jason C. O'Connor;Gregory G. Freund;Rodney W. Johnson.
Nature Reviews Neuroscience (2008)

5807 Citations

Twenty years of research on cytokine-induced sickness behavior

Robert Dantzer;Keith W. Kelley.
Brain Behavior and Immunity (2007)

1331 Citations

Sickness behavior as a new target for drug development

Stephen Kent;Rose Marie Bluthé;Keith W. Kelley;Robert Dantzer.
Trends in Pharmacological Sciences (1992)

1027 Citations

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

Jason O'Connor;M. A. Lawson;C. André;M. Moreau.
Molecular Psychiatry (2009)

1019 Citations

Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system

J. P. Godbout;J. Chen;J. Abraham;A. F. Richwine.
The FASEB Journal (2005)

810 Citations

Cytokine-induced sickness behavior

Keith W. Kelley;Rose Marie Bluthé;Robert Dantzer;Jian Hua Zhou.
Brain Behavior and Immunity (2003)

804 Citations

Stress and immunity: an integrated view of relationships between the brain and the immune system.

Robert Dantzer;Keith W. Kelley.
Life Sciences (1989)

723 Citations

Inflammation-associated depression: From serotonin to kynurenine

Robert Dantzer;Jason C. O’Connor;Marcus A. Lawson;Keith W. Kelley.
Psychoneuroendocrinology (2011)

635 Citations

CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-α: relationship to CNS immune responses and depression

Charles L. Raison;Robert Dantzer;Keith W. Kelley;Marcus A. Lawson.
Molecular Psychiatry (2010)

565 Citations

Interferon-γ and Tumor Necrosis Factor-α Mediate the Upregulation of Indoleamine 2,3-Dioxygenase and the Induction of Depressive-Like Behavior in Mice in Response to Bacillus Calmette-Guérin

Jason C. O'Connor;Caroline André;Yunxia Wang;Marcus A. Lawson.
The Journal of Neuroscience (2009)

502 Citations

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