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Biology and Biochemistry

D-Index
71
Citations
23757
World Ranking
6540
National Ranking
167

Overview

Geert J. P. L. Kops is affiliated with the Royal Netherlands Academy of Arts and Sciences in the Netherlands. Their research primarily focuses on molecular biology, cell biology, oncology, and plant science, with a significant concentration on biochemistry, genetics, and molecular biology overall. They have contributed extensively to the fields of microtubule and mitosis dynamics, chromosomal and genetic variations, cancer genomics and diagnostics, genomics and chromatin dynamics, genetic factors in colorectal cancer, and genomics and phylogenetic studies.

Kops has published research in several notable venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Trends in Cell Biology
  • Nature Communications
  • Current Biology
  • Human Reproduction

The scientist's recent publications include:

  • "Principles and dynamics of spindle assembly checkpoint signalling," 2023, Nature Reviews Molecular Cell Biology
  • "Nuclear chromosome locations dictate segregation error frequencies," 2022, Nature
  • "Molecular characterization of colorectal cancer related peritoneal metastatic disease," 2022, Nature Communications
  • "Degree and site of chromosomal instability define its oncogenic potential," 2020, Nature Communications
  • "Evolutionary Dynamics of the Spindle Assembly Checkpoint in Eukaryotes," 2020, Current Biology

Frequent co-authors in Kops's research include:

  • Eelco C. Tromer
  • William C. Earnshaw
  • Sjoerd J. Klaasen
  • Berend Snel
  • Nico Lansu

The main fields of study for Kops include biochemistry, genetics, and molecular biology, with notable contributions to medicine. Their subfields cover molecular biology, cell biology, oncology, plant science, and cancer research. Their work focuses on topics such as microtubule and mitosis dynamics, chromosomal and genetic variations, protist diversity and phylogeny, cancer genomics and diagnostics, genomics and chromatin dynamics, genetic factors in colorectal cancer, and genomics and phylogenetic studies.

Best Publications

  • Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

    Geert J. P. L. Kops;Tobias B. Dansen;Paulien E. Polderman;Ingrid Saarloos

  • AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1.

    René H. Medema;Geert J. P. L. Kops;Johannes L. Bos;Boudewijn M. T. Burgering

  • On the road to cancer: aneuploidy and the mitotic checkpoint.

    Geert J. P. L. Kops;Beth A. A. Weaver;Don W. Cleveland

  • Direct control of the Forkhead transcription factor AFX by protein kinase B

    Kops Gj;de Ruiter Nd;De Vries-Smits Am;Powell Dr

  • Sequential cancer mutations in cultured human intestinal stem cells

    Jarno Drost;Richard H. van Jaarsveld;Bas Ponsioen;Cheryl Zimberlin

  • Cell cycle and death control: long live Forkheads.

    Boudewijn M.T Burgering;Geert J.P.L Kops

  • The Forkhead Transcription Factor FoxO Regulates Transcription of p27Kip1 and Bim in Response to IL-2

    Marie Stahl;Pascale F. Dijkers;Geert J. P. L. Kops;Susanne M. A. Lens

  • Cell Cycle Inhibition by FoxO Forkhead Transcription Factors Involves Downregulation of Cyclin D

    Marc Schmidt;Sylvia Fernandez de Mattos;Armando van der Horst;Rob Klompmaker

  • Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome Aberrations

    Aniek Janssen;Marja van der Burg;Karoly Szuhai;Geert J. P. L. Kops

  • Control of Cell Cycle Exit and Entry by Protein Kinase B-Regulated Forkhead Transcription Factors

    Geert J. P. L. Kops;Rene H. Medema;Janet Glassford;Marieke A. G. Essers

  • Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint

    Geert J. P. L. Kops;Daniel R. Foltz;Don W. Cleveland;Don W. Cleveland

  • Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension

    Susanne M.A. Lens;Rob M.F. Wolthuis;Rob Klompmaker;Jos Kauw

  • Inhibition of Nuclear Import by Protein Kinase B (Akt) Regulates the Subcellular Distribution and Activity of the Forkhead Transcription Factor AFX

    Amy M. Brownawell;Geert J. P. L. Kops;Ian G. Macara;Boudewijn M. T. Burgering

  • Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment.

    Nannette Jelluma;Arjan B. Brenkman;Niels J.F. van den Broek;Carin W.A. Cruijsen

  • Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling.

    Geert J.P.L. Kops;Boudewijn M.T. Burgering

  • Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells

    Aniek Janssen;Geert J. P. L. Kops;René H. Medema

  • Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss

    Beth A.A. Weaver;Zahid Q. Bonday;Frances R. Putkey;Geert J.P.L. Kops

  • ZW10 links mitotic checkpoint signaling to the structural kinetochore

    Geert J.P.L. Kops;Yumi Kim;Beth A.A. Weaver;Yinghui Mao

  • Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy

    Else Driehuis;Sigrid Kolders;Sacha Spelier;Kadi Lõhmussaar

  • Erratum to: Transgenic rats expressing the human ET-2 gene: a model for the study of endothelin actions in vivo

    Lutz Liefeldt;Gilbert Schönfelder;Wolfgang Böcker;Berthold Hocher

Frequent Co-Authors

René H. Medema
René H. Medema Princess Máxima Center
Berend Snel
Berend Snel Utrecht University
Boudewijn M. T. Burgering
Boudewijn M. T. Burgering Utrecht University
Don W. Cleveland
Don W. Cleveland University of California, San Diego
Susanne M.A. Lens
Susanne M.A. Lens Utrecht University
Andrea Musacchio
Andrea Musacchio Max Planck Society
Anastassis Perrakis
Anastassis Perrakis Antoni van Leeuwenhoek Hospital
Alexander van Oudenaarden
Alexander van Oudenaarden University Medical Center Utrecht
Jagesh V. Shah
Jagesh V. Shah Harvard University
Johannes L. Bos
Johannes L. Bos Utrecht University

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