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Nathan K. LeBrasseur

Nathan K. LeBrasseur

D-Index & Metrics

Medicine

D-Index
76
Citations
33024
World Ranking
18622
National Ranking
9276

Overview

Nathan K. LeBrasseur is affiliated with the Mayo Clinic in the United States and has authored numerous publications primarily in the fields of Medicine and Biochemistry, Genetics, and Molecular Biology. Their research spans several subfields including Physiology, Molecular Biology, Immunology, Aging, and Geriatrics and Gerontology.

LeBrasseur's work covers key topics such as Telomeres, Telomerase, and Senescence; Nutrition and Health in Aging; Genetics, Aging, and Longevity in Model Organisms; Frailty in Older Adults; Adipose Tissue and Metabolism; Neutrophil, Myeloperoxidase and Oxidative Mechanisms; and Muscle Physiology and Disorders.

Among their recent notable papers are:

  • A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues (2022, Nature Communications)
  • Apoptotic stress causes mtDNA release during senescence and drives the SASP (2023, Nature)
  • Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice (2021, Aging Cell)
  • The senescence-associated secretome as an indicator of age and medical risk (2020, JCI Insight)
  • Senolytics reduce coronavirus-related mortality in old mice (2021, Science)

Frequent co-authors collaborating with LeBrasseur include:

  • Elizabeth J. Atkinson
  • Sundeep Khosla
  • Xu Zhang
  • Thomas A. White
  • João F. Passos

LeBrasseur's publications are often found in venues with a focus on aging and physiology. These include:

  • Innovation in Aging
  • Aging Cell
  • The Journals of Gerontology Series A
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications

The breadth of LeBrasseur's research contributions emphasizes physiological and molecular mechanisms related to aging and muscle function, with an emphasis on cellular senescence and associated biological pathways. This body of work situates them at the intersection of clinical and molecular approaches to aging and age-related diseases.

Best Publications

  • Clearance of p16 Ink4a -positive senescent cells delays ageing-associated disorders

    Darren J. Baker;Tobias Wijshake;Tamar Tchkonia;Nathan K. LeBrasseur

  • The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

    Yi-Yi Zhu;Tamara Tchkonia;Tamar Pirtskhalava;Adam C Gower

  • Senolytics improve physical function and increase lifespan in old age

    Ming Xu;Ming Xu;Tamar Pirtskhalava;Joshua N. Farr;Bettina M. Weigand;Bettina M. Weigand

  • Adverse Events Associated with Testosterone Administration

    Shehzad Basaria;Andrea D. Coviello;Thomas G. Travison;Thomas W. Storer

  • Cellular senescence mediates fibrotic pulmonary disease

    Marissa J. Schafer;Thomas A. White;Koji Iijima;Andrew J. Haak

  • Targeting cellular senescence prevents age-related bone loss in mice

    Joshua N Farr;Ming Xu;Megan M Weivoda;David G Monroe

  • Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease.

    La Tonya J. Hickson;Larissa G.P. Langhi Prata;Shane A. Bobart;Tamara K. Evans

  • Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study.

    Jamie N. Justice;Anoop M. Nambiar;Tamar Tchkonia;Nathan K. LeBrasseur

  • Skeletal Muscle Fiber-type Switching, Exercise Intolerance, and Myopathy in PGC-1α Muscle-specific Knock-out Animals

    Christoph Handschin;Sherry Chin;Ping Li;Fenfen Liu

  • JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

    Ming Xu;Tamara Tchkonia;Husheng Ding;Mikolaj Ogrodnik;Mikolaj Ogrodnik

  • Targeting senescent cells alleviates obesity‐induced metabolic dysfunction

    Allyson K. Palmer;Ming Xu;Ming Xu;Yi Zhu;Tamar Pirtskhalava

  • High-Velocity Resistance Training Increases Skeletal Muscle Peak Power in Older Women

    Roger A. Fielding;Nathan K. LeBrasseur;Anthony Cuoco;Jonathan Bean

  • Targeting senescent cells enhances adipogenesis and metabolic function in old age

    Ming Xu;Allyson K Palmer;Husheng Ding;Megan M Weivoda

  • Fast/Glycolytic muscle fiber growth reduces fat mass and improves metabolic parameters in obese mice.

    Yasuhiro Izumiya;Teresa Hopkins;Carl Morris;Kaori Sato

  • The Transcriptional Coactivator PGC-1β Drives the Formation of Oxidative Type IIX Fibers in Skeletal Muscle

    Zoltan Arany;Nathan Lebrasseur;Carl Morris;Eric Smith

  • High-Intensity Resistance Training Improves Muscle Strength, Self-Reported Function, and Disability in Long-Term Stroke Survivors

    Michelle M. Ouellette;Nathan K. LeBrasseur;Jonathan F. Bean;Edward Phillips

  • Identification of Senescent Cells in the Bone Microenvironment

    Joshua N Farr;Daniel G Fraser;Haitao Wang;Katharina Jaehn

  • Deletion of Cavin/PTRF causes global loss of caveolae, dyslipidemia, and glucose intolerance.

    Libin Liu;Dennis Brown;Mary McKee;Nathan K. LeBrasseur

  • Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence

    Rhys Anderson;Anthony Lagnado;Damien Maggiorani;Anna Walaszczyk

  • Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity.

    Allyson K. Palmer;Tamara Tchkonia;Nathan K. LeBrasseur;Eduardo N. Chini

Frequent Co-Authors

Thomas A. White
Thomas A. White Mayo Clinic
Sundeep Khosla
Sundeep Khosla Mayo Clinic
Tamar Tchkonia
Tamar Tchkonia Cedars-Sinai Medical Center
Roger A. Fielding
Roger A. Fielding Tufts University
Shalender Bhasin
Shalender Bhasin Brigham and Women's Hospital
Douglas B. Sawyer
Douglas B. Sawyer Maine Medical Center
João F. Passos
João F. Passos Mayo Clinic

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