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Immunology

D-Index
66
Citations
19229
World Ranking
2731
National Ranking
1302

Overview

Michael A. Brehm is affiliated with the University of Massachusetts Chan Medical School in the United States. Their research spans multiple areas within medicine, biochemistry, genetics, molecular biology, immunology, and microbiology. The scientist's work includes significant contributions in immunology, oncology, molecular biology, genetics, and surgery.

Their recent publications cover a range of topics, reflecting a focus on immune system interactions, diabetes-related research, and cancer immunology. Notable papers include:

  • Humanized mouse models for immuno-oncology research (2023), published in Nature Reviews Clinical Oncology
  • Innovations, challenges, and minimal information for standardization of humanized mice (2020), published in EMBO Molecular Medicine
  • Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells (2020), published in Cell Reports
  • Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead (2024), published in Nature Reviews Endocrinology
  • γδ T cell dichotomy with opposing cytotoxic and wound healing functions in human solid tumors (2023), published in Nature Cancer

Michael A. Brehm frequently collaborates with several researchers, including:

  • Dale L. Greiner
  • Leonard D. Shultz
  • James Keck
  • Mingshan Cheng
  • Li-Chin Yao

The scientist's work appears regularly in respected publication venues, such as:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • The FASEB Journal
  • Blood
  • Transplantation

Michael A. Brehm's research focuses on several key topics, including:

  • Immune Cell Function and Interaction
  • Pancreatic function and diabetes
  • Diabetes and associated disorders
  • CAR-T cell therapy research
  • Monoclonal and Polyclonal Antibodies Research
  • Immunotherapy and Immune Responses
  • Diabetes Management and Research

Best Publications

  • Repair of Infarcted Myocardium by Autologous Intracoronary Mononuclear Bone Marrow Cell Transplantation in Humans

    Bodo E. Strauer;Michael Brehm;Tobias Zeus;Matthias Köstering

  • Humanized mice for immune system investigation: progress, promise and challenges.

    Leonard D. Shultz;Michael A. Brehm;J. Victor Garcia-Martinez;Dale L. Greiner

  • Humanized Mouse Models of Clinical Disease.

    Nicole C. Walsh;Laurie L. Kenney;Sonal Jangalwe;Ken-Edwin Aryee

  • Regeneration of Human Infarcted Heart Muscle by Intracoronary Autologous Bone Marrow Cell Transplantation in Chronic Coronary Artery Disease: The IACT Study

    Bodo E. Strauer;Michael Brehm;Tobias Zeus;Thomas Bartsch

  • Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex.

    M A King;L Covassin;M A Brehm;W Racki

  • An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.

    Birgit Knoechel;Justine E Roderick;Kaylyn E Williamson;Jiang Zhu

  • Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation.

    Michael A. Brehm;Amy Cuthbert;Chaoxing Yang;David M. Miller

  • Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy

    Minan Wang;Li Chin Yao;Mingshan Cheng;Danying Cai

  • Humanized mouse models for immuno-oncology research

    Unknown

  • The BALANCE Study: clinical benefit and long-term outcome after intracoronary autologous bone marrow cell transplantation in patients with acute myocardial infarction.

    Muhammad Yousef;Christiana Mira Schannwell;Mathias Köstering;Tobias Zeus

  • Human 'brite/beige' adipocytes develop from capillary networks, and their implantation improves metabolic homeostasis in mice

    So Yun Min;Jamie Kady;Minwoo Nam;Raziel Rojas-Rodriguez

  • Heterologous immunity between viruses

    Raymond M. Welsh;Jenny Wun-Yue Che;Michael A. Brehm;Liisa K. Selin

  • Memory CD8+ T cells in heterologous antiviral immunity and immunopathology in the lung.

    Hong D. Chen;Armando E. Fraire;Isabelle Joris;Michael A. Brehm

  • T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens

    Michael A. Brehm;Amelia K. Pinto;Amelia K. Pinto;Keith A. Daniels;Jonathan P. Schneck

  • Attrition of Bystander CD8 T Cells during Virus-Induced T-Cell and Interferon Responses

    James M. McNally;Christopher C. Zarozinski;Meei-Yun Lin;Michael A. Brehm

  • Humanized mouse models to study human diseases.

    Michael A Brehm;Leonard D Shultz;Dale L Greiner

  • Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance

    Ian A. York;Michael A. Brehm;Sophia Zendzian;Charles Fenton Towne

  • Humanized immune system mouse models: progress, challenges and opportunities.

    Todd M. Allen;Michael A. Brehm;Sandra Bridges;Stacy Ferguson

  • Memory of mice and men: CD8+ T-cell cross-reactivity and heterologous immunity.

    Liisa K. Selin;Michael A. Brehm;Yuri N. Naumov;Markus Cornberg

  • Virus-Induced Abrogation of Transplantation Tolerance Induced by Donor-Specific Transfusion and Anti-CD154 Antibody

    Raymond M. Welsh;Thomas G. Markees;Bruce A. Woda;Keith A. Daniels

  • Direct Visualization of Cross-Reactive Effector and Memory Allo-Specific CD8 T Cells Generated in Response to Viral Infections

    Michael A. Brehm;Thomas G. Markees;Keith A. Daniels;Dale L. Greiner

  • TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts.

    Thomas B. Thornley;Michael A. Brehm;Thomas G. Markees;Leonard D. Shultz

Frequent Co-Authors

Dale L. Greiner
Dale L. Greiner University of Massachusetts Chan Medical School
Leonard D. Shultz
Leonard D. Shultz Jackson Laboratory
Raymond M. Welsh
Raymond M. Welsh University of Massachusetts Chan Medical School
Aldo A. Rossini
Aldo A. Rossini University of Massachusetts Chan Medical School
Liisa K. Selin
Liisa K. Selin University of Massachusetts Chan Medical School
Peter Wernet
Peter Wernet Heinrich Heine University Düsseldorf
Markus Cornberg
Markus Cornberg Hannover Medical School
Gesine Kögler
Gesine Kögler Heinrich Heine University Düsseldorf
Jeremy Luban
Jeremy Luban University of Massachusetts Chan Medical School
Leslie J. Berg
Leslie J. Berg University of Colorado Anschutz Medical Campus

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