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Overview

Samuel Waxman is affiliated with the Icahn School of Medicine at Mount Sinai in the United States. Their research activity predominantly spans the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Within these areas, their work is especially concentrated in subfields such as Molecular Biology, Hematology, and Oncology, with additional focus on Cancer Research and Aging.

The scientist's main research topics include cell death mechanisms and regulation, acute myeloid leukemia research, cancer therapeutics and mechanisms, histone deacetylase inhibitors research, and retinoids in leukemia and cellular processes. They have also contributed to studies involving genetics, aging, and longevity in model organisms, along with protein degradation and inhibitors.

Samuel Waxman has published multiple articles in notable scientific venues. Frequent publication outlets include Cancer Research with six papers, Aging and Cancer with two papers, and one paper each in Aging, Translational Oncology, and Cell Death and Disease.

Recent publications cover diverse areas of cancer biology and therapeutics. Examples include:

  • Cancer mortality in the oldest old: a global overview (2020, Aging)
  • Invasive phenotype in triple negative breast cancer is inhibited by blocking SIN3A-PF1 interaction through KLF9 mediated repression of ITGA6 and ITGB1 (2021, Translational Oncology)
  • Artesunate improves venetoclax plus cytarabine AML cell targeting by regulating the Noxa/Bim/Mcl-1/p-Chk1 axis (2022, Cell Death and Disease)
  • The GSK3β/Mcl-1 axis is regulated by both FLT3-ITD and Axl and determines the apoptosis induction abilities of FLT3-ITD inhibitors (2023, Cell Death Discovery)
  • Replacing the tropolonic methoxyl group of colchicine with methylamino increases tubulin binding affinity with improved therapeutic index and overcomes paclitaxel cross-resistance (2023, Drug Resistance Updates)

The scientist has collaborated frequently with several colleagues, including Yongkui Jing (11 publications), Linxiang Zhao (6 publications), Ping Gong (4 publications), Jingyi Zhang (3 publications), and Yuetong Wang (3 publications).

Best Publications

  • Mechanisms of action of arsenic trioxide.

    Wilson H. Miller;Hyman M. Schipper;Janet S. Lee;Jack Singer

  • Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL) : I. As2O3 exerts dose-dependent dual effects on APL cells

    Guo-Qiang Chen;Xue-Geng Shi;Wei Tang;Shu-Min Xiong

  • Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia.

    Zhu Chen;Nigel J. Brand;Alex Chen;Sai Juan Chen

  • Pivotal Role of mTOR Signaling in Hepatocellular Carcinoma

    Augusto Villanueva;Derek Y. Chiang;Pippa Newell;Judit Peix

  • Malignant Cells Can Be Sensitized to Undergo Growth Inhibition and Apoptosis by Arsenic Trioxide Through Modulation of the Glutathione Redox System

    Jie Dai;Rona S. Weinberg;Samuel Waxman;Yongkui Jing

  • Arsenic Trioxide Selectively Induces Acute Promyelocytic Leukemia Cell Apoptosis Via a Hydrogen Peroxide-Dependent Pathway

    Yongkui Jing;Jie Dai;Ruth M.E. Chalmers-Redman;Willam G. Tatton

  • Identification of an Immune-specific Class of Hepatocellular Carcinoma, Based on Molecular Features

    Daniela Sia;Yang Jiao;Iris Martinez-Quetglas;Olga Kuchuk;Olga Kuchuk

  • All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia.

    Zhi-Xiang Shen;Zhan-Zhong Shi;Jing Fang;Bai-Wei Gu

  • Focal Gains of VEGFA and Molecular Classification of Hepatocellular Carcinoma

    Derek Y. Chiang;Augusto Villanueva;Yujin Hoshida;Yujin Hoshida;Judit Peix

  • Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma

    Elisa Wurmbach;Ying Bei Chen;Greg Khitrov;Weijia Zhang

  • Studies on treatment of acute promyelocytic leukemia with arsenic trioxide: remission induction, follow-up, and molecular monitoring in 11 newly diagnosed and 47 relapsed acute promyelocytic leukemia patients.

    Chao Niu;Hua Yan;Ting Yu;Hui-Ping Sun

  • Integrative molecular analysis of intrahepatic cholangiocarcinoma reveals 2 classes that have different outcomes.

    Daniela Sia;Yujin Hoshida;Augusto Villanueva;Sasan Roayaie

  • Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia

    Jiong Hu;Yuan Fang Liu;Chuan Feng Wu;Fang Xu

  • A Molecular Signature to Discriminate Dysplastic Nodules From Early Hepatocellular Carcinoma in HCV Cirrhosis

    Josep M. Llovet;Yingbei Chen;Elisa Wurmbach;Sasan Roayaie

  • History of the Development of Arsenic Derivatives in Cancer Therapy

    Samuel Waxman;Kenneth C. Anderson

  • Arsenic Trioxide as an Inducer of Apoptosis and Loss of PML/RARα Protein in Acute Promyelocytic Leukemia Cells

    W. Shao;M. Fanelli;F. F. Ferrara;R. Riccioni

  • Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17).

    Jonathan D. Licht;Christine Chomienne;Andre Goy;Alex Chen

  • Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression

    Byoung Kwon Yoo;Luni Emdad;Zao-zhong Su;Augusto Villanueva

  • Reduced Retinoic Acid-Sensitivities of Nuclear Receptor Corepressor Binding to PML- and PLZF-RARα Underlie Molecular Pathogenesis and Treatment of Acute Promyelocytic Leukemia

    Fabien Guidez;Sarah Ivins;Sarah Ivins;Sarah Ivins;Jun Zhu;Jun Zhu;Jun Zhu;Mats Söderström;Mats Söderström;Mats Söderström

  • Induction of cell migration by pro-urokinase binding to its receptor : possible mechanism for signal transduction in human epithelial cells

    N Busso;S K Masur;D Lazega;S Waxman

Frequent Co-Authors

Arthur Zelent
Arthur Zelent University of Miami
Jonathan D. Licht
Jonathan D. Licht University of Florida
Josep M. Llovet
Josep M. Llovet University of Barcelona
Zhu Chen
Zhu Chen Shanghai Jiao Tong University
Myron Schwartz
Myron Schwartz Icahn School of Medicine at Mount Sinai
Vincenzo Mazzaferro
Vincenzo Mazzaferro University of Milan
Swan N. Thung
Swan N. Thung Icahn School of Medicine at Mount Sinai
Ming-Ming Zhou
Ming-Ming Zhou Icahn School of Medicine at Mount Sinai
Guo-Qiang Chen
Guo-Qiang Chen Tsinghua University
Scott L. Friedman
Scott L. Friedman Icahn School of Medicine at Mount Sinai

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