D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 78 Citations 36,821 268 World Ranking 1927 National Ranking 32
Medicine D-index 77 Citations 25,964 194 World Ranking 10857 National Ranking 107

Research.com Recognitions

Awards & Achievements

2017 - Fellow of the American Academy of Arts and Sciences

2013 - Fellow of the Royal Society, United Kingdom

2006 - Member of Academia Europaea

2003 - Member of the National Academy of Sciences

1999 - Fellow, The World Academy of Sciences

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Cancer

Zhu Chen mainly investigates Acute promyelocytic leukemia, Genetics, Arsenic trioxide, Leukemia and Cancer research. His work carried out in the field of Acute promyelocytic leukemia brings together such families of science as Internal medicine and Tretinoin, Cellular differentiation. His research investigates the link between Genetics and topics such as Evolutionary biology that cross with problems in Haplotype and Y chromosome.

He combines subjects such as Combination therapy, Pathogenesis and Acute promyelocytic leukaemia with his study of Arsenic trioxide. His Leukemia research is multidisciplinary, incorporating perspectives in Myeloid and Myeloid leukemia. His Cancer research research incorporates elements of Mutation, Exome sequencing, Exome and Chemotherapy.

His most cited work include:

  • Effectiveness of convalescent plasma therapy in severe COVID-19 patients. (1013 citations)
  • Acute promyelocytic leukemia: from highly fatal to highly curable. (907 citations)
  • A Human Genome Diversity Cell Line Panel (849 citations)

What are the main themes of his work throughout his whole career to date?

Zhu Chen mainly focuses on Cancer research, Acute promyelocytic leukemia, Leukemia, Molecular biology and Cell biology. His primary area of study in Cancer research is in the field of Myeloid leukemia. His biological study spans a wide range of topics, including Arsenic trioxide and Tretinoin, Cellular differentiation.

His Arsenic trioxide research incorporates themes from Gastroenterology and Internal medicine, Chemotherapy. In his research, CD34 is intimately related to Myeloid, which falls under the overarching field of Leukemia. His research integrates issues of Gene rearrangement, Chromosomal translocation, Fusion gene, Gene and Regulation of gene expression in his study of Molecular biology.

He most often published in these fields:

  • Cancer research (36.39%)
  • Acute promyelocytic leukemia (23.99%)
  • Leukemia (24.80%)

What were the highlights of his more recent work (between 2015-2021)?

  • Cell biology (18.87%)
  • Cancer research (36.39%)
  • Leukemia (24.80%)

In recent papers he was focusing on the following fields of study:

The scientist’s investigation covers issues in Cell biology, Cancer research, Leukemia, Haematopoiesis and Myeloid leukemia. His research in Cancer research intersects with topics in Mutation, Fusion gene, Acute promyelocytic leukemia, Promyelocytic leukemia protein and Genome. The Acute promyelocytic leukemia study combines topics in areas such as Internal medicine, Toxicity and Targeted therapy.

His studies in Leukemia integrate themes in fields like Myeloid and Immunophenotyping. His Myeloid leukemia research is multidisciplinary, incorporating elements of Molecular biology, Downregulation and upregulation and DOT1L. He interconnects Arsenic trioxide and Retinoic acid in the investigation of issues within Pharmacology.

Between 2015 and 2021, his most popular works were:

  • Effectiveness of convalescent plasma therapy in severe COVID-19 patients. (1013 citations)
  • Genomic Profiling of Adult and Pediatric B-cell Acute Lymphoblastic Leukemia. (115 citations)
  • The P4 Health Spectrum – A Predictive, Preventive, Personalized and Participatory Continuum for Promoting Healthspan (96 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Cancer

Zhu Chen mostly deals with Cancer research, Leukemia, Internal medicine, Myeloid leukemia and Cell biology. His Cancer research study integrates concerns from other disciplines, such as Kinase activity, Targeted therapy, Gefitinib, Lung cancer and Promyelocytic leukemia protein. The concepts of his Leukemia study are interwoven with issues in Myeloid, Receptor, Immunophenotyping, CD19 and Immunotherapy.

His work deals with themes such as Gastroenterology and Antibody, which intersect with Internal medicine. His Myeloid leukemia research includes elements of Molecular biology and Downregulation and upregulation. His Gene expression research is multidisciplinary, relying on both Acute promyelocytic leukemia and Retinoic acid.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

A Human Genome Diversity Cell Line Panel

.
Science (2002)

2249 Citations

Acute promyelocytic leukemia: from highly fatal to highly curable.

Zhen-Yi Wang;Zhu Chen.
Blood (2008)

1419 Citations

KCNQ1 gain-of-function mutation in familial atrial fibrillation

Yi-Han Chen;Shi-Jie Xu;Saı̈d Bendahhou;Xiao-Liang Wang.
Science (2003)

1194 Citations

In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins

Guo-Qiang Chen;Jun Zhu;Xue-Geng Shi;Jian-Hua Ni.
Blood (1996)

1121 Citations

Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL) : I. As2O3 exerts dose-dependent dual effects on APL cells

Guo-Qiang Chen;Xue-Geng Shi;Wei Tang;Shu-Min Xiong.
Blood (1997)

946 Citations

Fusion between a novel Krüppel‐like zinc finger gene and the retinoic acid receptor‐alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia.

Zhu Chen;Nigel J. Brand;Alex Chen;Sai Juan Chen.
The EMBO Journal (1993)

889 Citations

Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia

Xiao-Jing Yan;Jie Xu;Zhao-Hui Gu;Chun-Ming Pan.
Nature Genetics (2011)

869 Citations

Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia

Lan Wang;Guang Biao Zhou;Guang Biao Zhou;Ping Liu;Jun Hong Song.
Proceedings of the National Academy of Sciences of the United States of America (2008)

740 Citations

Arsenic Trioxide Controls the Fate of the PML-RARα Oncoprotein by Directly Binding PML

Xiao-Wei Zhang;Xiao-Jing Yan;Zi-Ren Zhou;Fei-Fei Yang.
Science (2010)

723 Citations

All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia.

Zhi-Xiang Shen;Zhan-Zhong Shi;Jing Fang;Bai-Wei Gu.
Proceedings of the National Academy of Sciences of the United States of America (2004)

671 Citations

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