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Malcolm E. Winkler

Malcolm E. Winkler

D-Index & Metrics

Biology and Biochemistry

D-Index
70
Citations
13532
World Ranking
7178
National Ranking
3293

Overview

Malcolm E. Winkler is affiliated with Indiana University in the United States. Their research primarily focuses on the fields of Biochemistry, Genetics and Molecular Biology, alongside Medicine. Within these broader areas, their work engages deeply with subfields such as Molecular Biology, Epidemiology, Public Health, Environmental and Occupational Health, Plant Science, and Genetics.

The scientist's research topics include Pneumonia and Respiratory Infections, RNA and protein synthesis mechanisms, Streptococcal Infections and Treatments, Bacterial Genetics and Biotechnology, RNA modifications and cancer, Glycosylation and Glycoproteins Research, and Antibiotic Resistance in Bacteria.

Malcolm E. Winkler has contributed publications to various scientific venues, with frequent appearances in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Microbiology
  • Nature Communications
  • Journal of Bacteriology
  • Frontiers in Microbiology

Their recent published papers cover important aspects of bacterial cell biology and molecular microbiology, including:

  • "Treadmilling FtsZ polymers drive the directional movement of sPG-synthesis enzymes via a Brownian ratchet mechanism," 2021, Nature Communications
  • "The Pneumococcal Divisome: Dynamic Control of Streptococcus pneumoniae Cell Division," 2021, Frontiers in Microbiology
  • "Biochemical reconstitution defines new functions for membrane-bound glycosidases in assembly of the bacterial cell wall," 2021, Proceedings of the National Academy of Sciences
  • "Organization of peptidoglycan synthesis in nodes and separate rings at different stages of cell division of Streptococcus pneumoniae," 2020, Molecular Microbiology
  • "FtsZ-Ring Regulation and Cell Division Are Mediated by Essential EzrA and Accessory Proteins ZapA and ZapJ in Streptococcus pneumoniae," 2021, Frontiers in Microbiology

Their work often intersects with the study of bacterial cell division mechanisms, bacterial cell wall synthesis, and the molecular machinery involved in streptococcal pathogens.

Collaborative efforts have involved frequent coauthors such as:

  • Ho-Ching Tiffany Tsui
  • Kevin E. Bruce
  • Amilcar J. Perez
  • Melissa M. Lamanna
  • Merrin Joseph

These coauthors reflect a network of research partners contributing to related microbiological and biochemical investigations. Winkler's publication record shows a consistent focus on molecular mechanisms within bacterial systems, particularly regarding pathogens relevant to human respiratory diseases and antibiotic resistance.

Best Publications

  • Genome of the bacterium Streptococcus pneumoniae strain R6.

    JoAnn Hoskins;William E. Alborn;Jeffrey Arnold;Larry C. Blaszczak

  • Phenotypic Landscape of a Bacterial Cell

    Robert J. Nichols;Saunak Sen;Yoe Jin Choo;Pedro Beltrao

  • Bacterial Pathogenesis : A Molecular Approach

    Brenda A. Wilson;Abigail A. Salyers;Dixie D Whitt;Malcolm E Winkler

  • Genome Sequence of Avery's Virulent Serotype 2 Strain D39 of Streptococcus pneumoniae and Comparison with That of Unencapsulated Laboratory Strain R6

    Joel A. Lanie;Wai-Leung Ng;Krystyna M. Kazmierczak;Tiffany M. Andrzejewski

  • Characterization of broadly pleiotropic phenotypes caused by an hfq insertion mutation in Escherichia coli K‐12

    Ho‐Ching Tiffany Tsui;Hon‐Chiu Eastwood Leung;Malcolm E. Winkler

  • Negative regulation of mutS and mutH repair gene expression by the Hfq and RpoS global regulators of Escherichia coli K-12.

    Ho-Ching Tiffany Tsui;Gang Feng;Malcolm E. Winkler

  • A novel alpha-ketoglutarate reductase activity of the serA-encoded 3-phosphoglycerate dehydrogenase of Escherichia coli K-12 and its possible implications for human 2-hydroxyglutaric aciduria.

    Genshi Zhao;M. E. Winkler

  • Biosynthesis of Histidine

    Malcolm E. Winkler;Smirla Ramos-Montañez

  • Depletion of the cellular amounts of the MutS and MutH methyl-directed mismatch repair proteins in stationary-phase Escherichia coli K-12 cells.

    Gang Feng;H.-C. T. Tsui;M. E. Winkler

  • Global Transcriptional Analysis of clpP Mutations of Type 2 Streptococcus pneumoniae and Their Effects on Physiology and Virulence

    Gregory T. Robertson;Wai-Leung Ng;Joseph Foley;Raymond Gilmour

  • Constitutive expression of PcsB suppresses the requirement for the essential VicR (YycF) response regulator in Streptococcus pneumoniae R6.

    Wai-Leung Ng;Gregory T. Robertson;Krystyna M. Kazmierczak;Krystyna M. Kazmierczak;Jingyong Zhao

  • Defective cell wall synthesis in Streptococcus pneumoniae R6 depleted for the essential PcsB putative murein hydrolase or the VicR (YycF) response regulator.

    Wai-Leung Ng;Krystyna M. Kazmierczak;Malcolm E. Winkler

  • Mismatch repair protein MutL becomes limiting during stationary-phase mutation

    Reuben S. Harris;Gang Feng;Kimberly J. Ross;Kimberly J. Ross;Roger Sidhu

  • Essential PcsB putative peptidoglycan hydrolase interacts with the essential FtsXSpn cell division protein in Streptococcus pneumoniae D39

    Lok-To Sham;Skye M. Barendt;Kimberly E. Kopecky;Malcolm E. Winkler

  • The Brucella abortus Cu,Zn Superoxide Dismutase Is Required for Optimal Resistance to Oxidative Killing by Murine Macrophages and Wild-Type Virulence in Experimentally Infected Mice

    Jason M. Gee;Jason M. Gee;Michelle Wright Valderas;Michael E. Kovach;Vanessa K. Grippe

  • Transcriptional Regulation and Signature Patterns Revealed by Microarray Analyses of Streptococcus pneumoniae R6 Challenged with Sublethal Concentrations of Translation Inhibitors

    Wai-Leung Ng;Krystyna M. Kazmierczak;Gregory T. Robertson;Raymond Gilmour

  • Kinetic limitation and cellular amount of pyridoxine (pyridoxamine) 5'-phosphate oxidase of Escherichia coli K-12.

    Genshi Zhao;Malcolm E. Winkler

  • Interplay between manganese and zinc homeostasis in the human pathogen Streptococcus pneumoniae

    Faith E. Jacobsen;Krystyna M. Kazmierczak;John P. Lisher;Malcolm E. Winkler

  • Identification and Function of the pdxY Gene, Which Encodes a Novel Pyridoxal Kinase Involved in the Salvage Pathway of Pyridoxal 5′-Phosphate Biosynthesis in Escherichia coli K-12

    Yong Yang;Ho-Ching Tiffany Tsui;Tsz-Kwong Man;Malcolm E. Winkler

  • Regulation of the pspA Virulence Factor and Essential pcsB Murein Biosynthetic Genes by the Phosphorylated VicR (YycF) Response Regulator in Streptococcus pneumoniae

    Wai-Leung Ng;Ho-Ching Tiffany Tsui;Malcolm E. Winkler

Frequent Co-Authors

David P. Giedroc
David P. Giedroc Indiana University
Reuben S. Harris
Reuben S. Harris The University of Texas Health Science Center at San Antonio
Susan M. Rosenberg
Susan M. Rosenberg Baylor College of Medicine
Daniel B. Kearns
Daniel B. Kearns Indiana University
Hon-Ming Lam
Hon-Ming Lam Chinese University of Hong Kong
Glenn R. Björk
Glenn R. Björk Umeå University
Donald A. Morrison
Donald A. Morrison University of Illinois at Chicago
Tadhg P. Begley
Tadhg P. Begley Texas A&M University
Richard J. Lewis
Richard J. Lewis University of Queensland
Cees Dekker
Cees Dekker Delft University of Technology

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