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Microbiology

D-Index
70
Citations
14883
World Ranking
1969
National Ranking
148

Overview

Regine Hakenbeck is affiliated with the Technical University of Kaiserslautern in Germany. Their research primarily spans the fields of Medicine with a strong focus on Epidemiology and Molecular Medicine.

The main topics of Regine Hakenbeck's work include:

  • Pneumonia and Respiratory Infections
  • Pneumocystis jirovecii pneumonia detection and treatment
  • Antibiotic Resistance in Bacteria
  • Respiratory viral infections research

Hakenbeck has published research in notable scientific venues such as:

  • Microorganisms
  • BMC Genomics

Two recent papers demonstrate their research approach and focus areas:

  • New Insights into Beta-Lactam Resistance of Streptococcus pneumoniae: Serine Protease HtrA Degrades Altered Penicillin-Binding Protein 2x, published in 2021 in Microorganisms
  • Correction: Evidence of antimicrobial resistance-conferring genetic elements among pneumococci isolated prior to 1974, published in 2023 in BMC Genomics

Their frequent coauthors reflect collaborative work across several projects and include:

  • Katharina Peters
  • Inga Schweizer
  • Dalia Denapaite
  • Kelly L. Wyres
  • Andries J. van Tonder

Hakenbeck's research contributions notably address mechanisms of antibiotic resistance in bacterial pathogens and methods for detection and treatment of respiratory infections. Their work spans molecular investigations and epidemiological studies, contributing to understanding pathogen behavior and resistance factors over time.

Best Publications

  • Bacterial cell wall

    Jean-Marie Ghuysen;CJ Knill;JF Kennedy;R Hakenbeck

  • Nomenclature of Major Antimicrobial-Resistant Clones of Streptococcus pneumoniae Defined by the Pneumococcal Molecular Epidemiology Network

    L. McGee;L. McDougal;J. Zhou;B. G. Spratt

  • Intercontinental Spread of a Multiresistant Clone of Serotype 23F Streptococcus pneumoniae

    Rosario Munoz;Tracey J. Coffey;Margaret Daniels;Christopher G. Dowson

  • A highly conserved repeated DNA element located in the chromosome of Streptococcus pneumoniae.

    Bernard Martin;Odile Humbert;Miguel Camara;Eric Guenzi

  • Enterococcus faecium strains with vanA-mediated high-level glycopeptide resistance isolated from animal foodstuffs and fecal samples of humans in the community.

    I. Klare;H. Heier;H. Claus;G. Böhme

  • Interspecies recombinational events during the evolution of altered PBP 2x genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae.

    G. Laible;B. G. Spratt;R. Hakenbeck

  • Natural competence in the genus Streptococcus: evidence that streptococci can change pherotype by interspecies recombinational exchanges.

    Leiv Sigve Håvarstein;Regine Hakenbeck;Peter Gaustad

  • Penicillin-binding proteins 2b and 2x of Streptococcus pneumoniae are primary resistance determinants for different classes of beta-lactam antibiotics.

    T Grebe;R Hakenbeck

  • A Functional dlt Operon, Encoding Proteins Required for Incorporation of d-Alanine in Teichoic Acids in Gram-Positive Bacteria, Confers Resistance to Cationic Antimicrobial Peptides in Streptococcus pneumoniae

    Márta Kovács;Alexander Halfmann;Iris Fedtke;Manuel Heintz

  • Mosaic genes and mosaic chromosomes: intra- and interspecies genomic variation of Streptococcus pneumoniae.

    Regine Hakenbeck;Nadège Balmelle;Beate Weber;Christophe Gardès

  • A two-component signal-transducing system is involved in competence and penicillin susceptibility in laboratory mutants of Streptococcus pneumoniae.

    Eric Guenzi;Anne-Marie Gasc;Michel A. Sicard;Regine Hakenbeck

  • Anthrax kills wild chimpanzees in a tropical rainforest

    Fabian H. Leendertz;Heinz Ellerbrok;Christophe Boesch;Emmanuel Couacy-Hymann

  • Acquisition of five high-Mr penicillin-binding protein variants during transfer of high-level beta-lactam resistance from Streptococcus mitis to Streptococcus pneumoniae.

    Regine Hakenbeck;Andrea König;Izabella Kern;Mark van der Linden

  • X-ray structure of Streptococcus pneumoniae PBP2x, a primary penicillin target enzyme

    S. Pares;N. Mouz;Y. Pétillot;R. Hakenbeck

  • Pneumolysin is the main inducer of cytotoxicity to brain microvascular endothelial cells caused by Streptococcus pneumoniae

    Gregor Zysk;Barbara Katharina Schneider-Wald;Jae Hyuk Hwang;Levente Bejo

  • Genetics of resistance to third-generation cephalosporins in clinical isolates of Streptococcus pneumoniae.

    Rosario Muñoz;Christopher G. Dowson;Maggie Daniels;Tracey J. Coffey

  • Identification of the genes directly controlled by the response regulator CiaR in Streptococcus pneumoniae: five out of 15 promoters drive expression of small non-coding RNAs

    Alexander Halfmann;Márta Kovács;Regine Hakenbeck;Reinhold Brückner

  • Multiple changes of penicillin-binding proteins in penicillin-resistant clinical isolates of Streptococcus pneumoniae

    Unknown

  • Pneumococcal Capsular Switching: A Historical Perspective

    Kelly L. Wyres;Lotte M. Lambertsen;Nicholas J. Croucher;Lesley McGee

  • beta-lactam resistance in Streptococcus pneumoniae: penicillin-binding proteins and non-penicillin-binding proteins.

    Regine Hakenbeck;Thorsten Grebe;Dorothea Zähner;Jeffry Benton Stock

  • A highly conserved repeated DNAelement located inthe chromosome ofStreptococcus pneumoniae

    Bernard Martin;Odile Humbert;Miguel Camara;Eric Guenzi

Frequent Co-Authors

Thomas Briese
Thomas Briese Columbia University
Waldemar Vollmer
Waldemar Vollmer Newcastle University
Thierry Vernet
Thierry Vernet French Alternative Energies and Atomic Energy Commission (CEA)
Fabian H. Leendertz
Fabian H. Leendertz Robert Koch Institute
Mark van der Linden
Mark van der Linden RWTH Aachen University
Heinz Ellerbrok
Heinz Ellerbrok Robert Koch Institute
Alexander Tomasz
Alexander Tomasz Rockefeller University
Josefina Liñares
Josefina Liñares University of Barcelona
Stephen D. Bentley
Stephen D. Bentley Wellcome Sanger Institute
Julian Parkhill
Julian Parkhill University of Cambridge

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