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Jürgen Harder

Jürgen Harder

D-Index & Metrics

Microbiology

D-Index
58
Citations
18167
World Ranking
3364
National Ranking
251

Overview

Jürgen Harder is affiliated with Kiel University in Germany and specializes in research across medicine with a strong emphasis on immunology and microbiology. Their work focuses primarily on dermatology and skin diseases, antimicrobial peptides and activities, allergic rhinitis and sensitization, immune response and inflammation, wound healing and treatments, periodontal regeneration and treatments, and the physiological responses related to exercise.

The scientist has contributed significantly to the understanding of interactions between antimicrobial peptides and the skin microbiota, along with investigating immune responses and treatments related to dermatological conditions. Their research often intersects with the molecular and immunological aspects of skin health and disease.

Frequent publication venues for this researcher include:

  • Journal of Investigative Dermatology
  • Scientific Reports
  • International Journal of Molecular Sciences
  • Experimental Dermatology
  • Nano Convergence

Key recent papers authored or co-authored by Jürgen Harder cover topics such as antioxidant-rich skin care products and their effects on atopic dermatitis, antimicrobial peptides interacting with skin microbiota, and the detailed molecular study of human beta defensin-3 activity against Gram-negative bacteria. Notable publications include:

  • Skin Care Product Rich in Antioxidants and Anti-Inflammatory Natural Compounds Reduces Itching and Inflammation in the Skin of Atopic Dermatitis Patients, 2022, Antioxidants
  • Antimicrobial peptides and proteins: Interaction with the skin microbiota, 2021, Experimental Dermatology
  • Influence of disulfide bonds in human beta defensin-3 on its strain specific activity against Gram-negative bacteria, 2020, Biochimica et Biophysica Acta (BBA) - Biomembranes
  • Skin microbiota analysis in human 3D skin models-"Free your mice", 2020, Experimental Dermatology
  • RNase 7 Promotes Sensing of Self-DNA by Human Keratinocytes and Activates an Antiviral Immune Response, 2020, Journal of Investigative Dermatology

Jürgen Harder collaborates frequently with a network of co-authors, including:

  • Franziska Rademacher
  • Regine Gläser
  • Stephan Weidinger
  • Nina Heinemann
  • Hila Emmert

The volumes of publications and collaboration reflect multidisciplinary contributions within dermatology, immunology, and microbiology, highlighting ongoing involvement in advancing research related to skin immunity and microbiota interactions.

Best Publications

  • Isolation and Characterization of Human μ-Defensin-3, a Novel Human Inducible Peptide Antibiotic

    Jurgen Harder;Joachin Bartels;Enno Christophers;Jens-Michael M Schröder

  • A peptide antibiotic from human skin

    J Harder;J Bartels;E Christophers;J M Schröder

  • NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression.

    J. Wehkamp;J. Harder;M. Weichenthal;M. Schwab

  • Antimicrobial psoriasin (S100A7) protects human skin from Escherichia coli infection

    Regine Gläser;Jürgen Harder;Hans Lange;Joachim Bartels

  • Human beta-defensin-2.

    Jens-M Schröder;Jürgen Harder

  • NF-κB- and AP-1-Mediated Induction of Human Beta Defensin-2 in Intestinal Epithelial Cells by Escherichia coli Nissle 1917: a Novel Effect of a Probiotic Bacterium

    Jan Wehkamp;Jürgen Harder;Kai Wehkamp;Birte Wehkamp-von Meissner

  • Mucoid Pseudomonas aeruginosa, TNF-alpha, and IL-1beta, but not IL-6, induce human beta-defensin-2 in respiratory epithelia

    Jürgen Harder;Ulf Meyer-Hoffert;Luis Manuel Teran;Lars Schwichtenberg

  • RNase 7, a Novel Innate Immune Defense Antimicrobial Protein of Healthy Human Skin *

    Jürgen Harder;Jens Michael Schröder

  • Cytosolic DNA Triggers Inflammasome Activation in Keratinocytes in Psoriatic Lesions

    Yvonne Dombrowski;Mark Peric;Sarah Koglin;Claudia Kammerbauer

  • Probiotic lactobacilli and VSL#3 induce enterocyte β-defensin 2

    M Schlee;J Harder;B Köten;E F Stange

  • NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2.

    Eske Voss;Jan Wehkamp;Kai Wehkamp;Eduard F. Stange

  • Antimicrobial skin peptides and proteins.

    J. M. Schröder;J. Harder

  • Psoriatic scales : a promising source for the isolation of human skin-derived antimicrobial proteins

    Jürgen Harder;Jens-Michael Schröder

  • Differential Gene Induction of Human β-Defensins (hBD-1, -2, -3, and -4) in Keratinocytes Is Inhibited by Retinoic Acid

    Jürgen Harder;Ulf Meyer-Hoffert;Kai Wehkamp;Lars Schwichtenberg

  • Enhanced expression and secretion of antimicrobial peptides in atopic dermatitis and after superficial skin injury.

    Jürgen Harder;Stefanie Dressel;Maike Wittersheim;Jesko Cordes

  • Activation of the Nlrp3 Inflammasome by Streptococcus pyogenes Requires Streptolysin O and NF-κB Activation but Proceeds Independently of TLR Signaling and P2X7 Receptor

    Jürgen Harder;Luigi Franchi;Raúl Muñoz-Planillo;Jong Hwan Park

  • Cutting Edge: Critical Role for Mesothelial Cells in Necrosis-Induced Inflammation through the Recognition of IL-1α Released from Dying Cells

    Tatjana Eigenbrod;Jong Hwan Park;Jürgen Harder;Yoichiro Iwakura

  • Antitumor Activity of the Antimicrobial Peptide Magainin II against Bladder Cancer Cell Lines

    Jan Lehmann;Margitta Retz;Sukhvinder S. Sidhu;Henrik Suttmann

  • Uncovering the evolutionary history of innate immunity: the simple metazoan Hydra uses epithelial cells for host defence.

    Thomas C.G. Bosch;René Augustin;Friederike Anton-Erxleben;Sebastian Fraune

  • Epidermal EGFR Controls Cutaneous Host Defense and Prevents Inflammation

    Beate M. Lichtenberger;Peter A. Gerber;Martin Holcmann;Bettina A. Buhren

Frequent Co-Authors

Jens-Michael Schröder
Jens-Michael Schröder Kiel University
Stephan Weidinger
Stephan Weidinger Kiel University
Enno Christophers
Enno Christophers Kiel University
Thomas Werfel
Thomas Werfel Hannover Medical School
Jan Wehkamp
Jan Wehkamp University of Tübingen
Thomas Schwarz
Thomas Schwarz Boston Children's Hospital
Eduard F. Stange
Eduard F. Stange Robert Bosch Hospital
Gabriel Núñez
Gabriel Núñez University of Michigan–Ann Arbor
Franz Rüschendorf
Franz Rüschendorf Max Delbrück Center for Molecular Medicine
Thomas Illig
Thomas Illig Hannover Medical School

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