World's Best Scientists 2026 revealed!

D-Index & Metrics

Immunology

D-Index
58
Citations
10243
World Ranking
3553
National Ranking
91

Overview

Wangxue Chen is affiliated with the National Research Council Canada. Their research spans multiple interconnected fields, primarily focusing on Medicine, Biochemistry, Genetics and Molecular Biology, and Mathematics. The scientist's work also involves significant contributions to subfields including Statistics and Probability, Molecular Biology, Statistics, Probability and Uncertainty, Epidemiology, and Infectious Diseases.

The body of work produced by Chen includes a strong emphasis on topics such as Statistical Distribution Estimation and Applications, Probabilistic and Robust Engineering Design, Bacteriophages and microbial interactions, Antibiotic Resistance in Bacteria, Fuzzy Systems and Optimization, Immunotherapy and Immune Responses, and SARS-CoV-2 and COVID-19 Research.

Chen has published extensively in various scientific venues. Frequent publication venues include Emerging Microbes & Infections, Applied Mathematics journals (such as Applied Mathematics. A Journal of Chinese Universities and Gao-xiao yingyong shuxue xuebao), Frontiers in Immunology, Communications in Statistics - Simulation and Computation, and Acta Mathematicae Applicatae Sinica English Series.

The scientist's recurring collaboration network includes coauthors such as Simon Sauvé, Xuguang Li, Wanyue Zhang, Caroline Gravel, and Danielle L. Peters, indicating a consistent engagement with peers across related research domains.

Recent publications by Chen highlight their focus on infectious diseases and immunological responses. Notable papers include:

  • Host Innate Immune Responses to Acinetobacter baumannii Infection, 2020, Frontiers in Cellular and Infection Microbiology
  • Promise and challenges in the development of COVID-19 vaccines, 2020, Human Vaccines & Immunotherapeutics

Though some recent papers involving related topics and coauthors cover immunogenic vaccines and molecular adjuvants, Chen's direct involvement is confirmed in key works that explore immune responses and vaccine development strategies.

Overall, Wangxue Chen's research integrates mathematical and biological sciences with a focus on practical medical applications, including vaccine development, infectious disease modeling, and the statistical underpinnings necessary for advancing these fields.

Best Publications

  • Activation of the mucosal immune system in irritable bowel syndrome.

    Vinton S. Chadwick;Wangxue Chen;Dairu Shu;Barbara Paulus

  • Intestinal M cells: The fallible sentinels?

    Harvey Miller;Jianbing Zhang;Rhonda KuoLee;Girishchandra B Patel

  • Importance of endogenous tumor necrosis factor alpha and gamma interferon in host resistance against Pneumocystis carinii infection

    Wangxue Chen;E. A. Havell;A. G. Harmsen

  • Neutrophils Play an Important Role in Host Resistance to Respiratory Infection with Acinetobacter baumannii in Mice

    Henk van Faassen;Rhonda KuoLee;Greg Harris;Xigeng Zhao

  • Experimental tularemia in mice challenged by aerosol or intradermally with virulent strains of Francisella tularensis: bacteriologic and histopathologic studies.

    J.Wayne Conlan;Wangxue Chen;Hua Shen;Ann Webb

  • A Mutant of Francisella tularensis Strain SCHU S4 Lacking the Ability To Express a 58-Kilodalton Protein Is Attenuated for Virulence and Is an Effective Live Vaccine

    Susan Twine;Mona Byström;Wangxue Chen;Mats Forsman

  • Viral haemorrhagic disease in rabbits: a review.

    Z J Xu;W X Chen

  • Induction of mucosal immunity through systemic immunization: Phantom or reality?

    Fei Su;Girishchandra B. Patel;Songhua Hu;Wangxue Chen

  • Requirements for CD4+ cells and gamma interferon in resolution of established Cryptosporidium parvum infection in mice.

    Wangxue Chen;J. A. Harp;A. G. Harmsen

  • Aerosol-, but not intradermal-immunization with the live vaccine strain of Francisella tularensis protects mice against subsequent aerosol challenge with a highly virulent type A strain of the pathogen by an αβ T cell- and interferon gamma- dependent mechanism

    J. Wayne Conlan;Hua Shen;Rhonda KuoLee;Xigeng Zhao

  • Tularemia in BALB/c and C57BL/6 mice vaccinated with Francisella tularensis LVS and challenged intradermally, or by aerosol with virulent isolates of the pathogen: protection varies depending on pathogen virulence, route of exposure, and host genetic background

    Wangxue Chen;Hua Shen;Ann Webb;Rhonda KuoLee

  • A Mouse Model of Acinetobacter baumannii-Associated Pneumonia Using a Clinically Isolated Hypervirulent Strain

    Greg Harris;Rhonda Kuo Lee;Christopher K. Lam;Gregory Kanzaki

  • Role of Macrophages in Early Host Resistance to Respiratory Acinetobacter baumannii Infection

    Hongyu Qiu;Rhonda KuoLee;Greg Harris;Nico Van Rooijen

  • Role of Toll-like receptors in health and diseases of gastrointestinal tract.

    Greg Harris;Rhonda KuoLee;Wangxue Chen

  • Resistance of severe combined immunodeficient mice to infection with Cryptosporidium parvum: the importance of intestinal microflora.

    J A Harp;W Chen;A G Harmsen

  • Modulation of Toxin Production by the Flagellar Regulon in Clostridium difficile

    Annie Aubry;Greg Hussack;Wangxue Chen;Rhonda KuoLee

  • Interleukin 1: an important mediator of host resistance against Pneumocystis carinii.

    Wangxue Chen;E. A. Havell;L. L. Moldawer;K. W. Mcintyre

  • Gamma interferon functions in resistance to Cryptosporidium parvum infection in severe combined immunodeficient mice.

    Wangxue Chen;J. A. Harp;A. G. Harmsen;E. A. Havell

  • Latency is not an inevitable outcome of infection with Pneumocystis carinii.

    Wangxue Chen;F. Gigliotti;A. G. Harmsen

  • Development of a dendritic cell (DC)-based vaccine for patients with advanced colorectal cancer.

    Natalie Rains;Rebecca J. Cannan;Wangxue Chen;Richard S. Stubbs

Frequent Co-Authors

Anders Sjöstedt
Anders Sjöstedt Umeå University
Allen G. Harmsen
Allen G. Harmsen Montana State University
Susan M. Logan
Susan M. Logan National Research Council Canada
Jianjun Li
Jianjun Li Chinese Academy of Sciences
Amine Kamen
Amine Kamen McGill University
Francis Gigliotti
Francis Gigliotti University of Rochester
Evgeny Vinogradov
Evgeny Vinogradov National Research Council Canada
Gary Van Domselaar
Gary Van Domselaar Public Health Agency of Canada
John F. Kelly
John F. Kelly National Academies of Sciences, Engineering, and Medicine
Simon J. Foote
Simon J. Foote Australian National University

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