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D-Index & Metrics

Biology and Biochemistry

D-Index
80
Citations
21330
World Ranking
4120
National Ranking
2022

Overview

Edward H. Leiter is affiliated with The Jackson Laboratory in the United States. Their recent research contributions include work published in peer-reviewed journals with a focus on the molecular and cellular mechanisms underlying pancreatic function and metabolic diseases.

One notable paper authored with frequent collaborators was published in 2022 titled "Intergenomic and epistatic interactions control free radical mediated pancreatic β-cell damage" in Frontiers in Genetics. This publication addresses genetic factors influencing cellular damage in pancreatic β-cells, which are critical to understanding diabetes pathology.

Edward H. Leiter's work spans several fields of study, with primary contributions in Medicine and Biochemistry, Genetics and Molecular Biology. Their subfields of study include:

  • Surgery
  • Cell Biology
  • Endocrinology, Diabetes and Metabolism

The main topics of scientific investigation cover:

  • Pancreatic function and diabetes
  • Endoplasmic Reticulum Stress and Disease
  • Diet, Metabolism, and Disease

Frequent co-authors collaborating with Edward H. Leiter include Jing Chen, Renhua Li, Sarah Knapp, Guizhi Zhu, and Robert L. Whitener. These collaborators have appeared together in research investigating the genetic and metabolic processes involved in disease mechanisms.

Their work has been published predominantly in the journal Frontiers in Genetics, which serves as a venue for genetics-related research findings. This reflects a consistent focus on genetic interactions and molecular biology approaches within their scientific output.

Best Publications

  • Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity

    Jürgen K. Naggert;Lloyd D. Fricker;Oleg Varlamov;Patsy M. Nishina

  • The NOD mouse model of type 1 diabetes: As good as it gets?

    Mark A. Atkinson;Edward H. Leiter

  • B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice.

    D V Serreze;H D Chapman;D S Varnum;M S Hanson

  • Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice. Relative contributions of CD4+ and CD8+ T-cells from diabetic versus prediabetic NOD.NON-Thy-1a donors.

    Sherri W Christianson;Leonard D Shultz;Edward H Leiter

  • B Lymphocytes Are Critical Antigen-Presenting Cells for the Initiation of T Cell-Mediated Autoimmune Diabetes in Nonobese Diabetic Mice

    David V. Serreze;Sara A. Fleming;Harold D. Chapman;Scott D. Richard

  • Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis

    Michael Mähler;Ian J. Bristol;Edward H. Leiter;Aletha E. Workman

  • Major Histocompatibility Complex Class I-Deficient NOD-B2mnull Mice are Diabetes and Insulitis Resistant

    David V Serreze;Edward H Leiter;Gregory J Christianson;Dale Greiner

  • The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency.

    M Prochazka;H R Gaskins;L D Shultz;E H Leiter

  • NIT-1, a pancreatic beta-cell line established from a transgenic NOD/Lt mouse.

    K Hamaguchi;H R Gaskins;E H Leiter

  • Lipid metabolome-wide effects of the PPARγ agonist rosiglitazone

    Steven M. Watkins;Peter R. Reifsnyder;Huei Ju Pan;J. Bruce German

  • Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes.

    Linda S Wicker;Edward H Leiter;John A Todd;Robert J Renjilian

  • Defects in the differentiation and function of antigen presenting cells in NOD/Lt mice.

    D V Serreze;H R Gaskins;E H Leiter

  • Defective activation of T suppressor cell function in nonobese diabetic mice. Potential relation to cytokine deficiencies.

    D V Serreze;E H Leiter

  • Effect of genetic background on the therapeutic effects of dehydroepiandrosterone (DHEA) in diabetes-obesity mutants and in aged normal mice.

    D L Coleman;R W Schwizer;E H Leiter

  • Carboxypeptidase E activity is deficient in mice with the fat mutation. Effect on peptide processing.

    Lloyd D. Fricker;Yemiliya L. Berman;Edward H. Leiter;Lakshmi A. Devi

  • Maternal environment and genotype interact to establish diabesity in mice.

    Peter C. Reifsnyder;Gary Churchill;Edward H. Leiter

  • Immunostimulation circumvents diabetes in NOD/Lt mice.

    David V. Serreze;Kazuyuki Hamaguchi;Edward H. Leiter

  • Hematopoietic stem-cell defects underlying abnormal macrophage development and maturation in NOD/Lt mice: defective regulation of cytokine receptors and protein kinase C

    David V. Serreze;Jens W. Gaedeke;Edward H. Leiter

  • NOD/LtSz-Rag1null Mice: An Immunodeficient and Radioresistant Model for Engraftment of Human Hematolymphoid Cells, HIV Infection, and Adoptive Transfer of NOD Mouse Diabetogenic T Cells

    Leonard D. Shultz;Pamela A. Lang;Sherri W. Christianson;Bruce Gott

  • The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse.

    Gustavo Glowacki;Rickmer Braren;Kathrin Firner;Marion Nissen

Frequent Co-Authors

David V. Serreze
David V. Serreze The Jackson Laboratory
Leonard D. Shultz
Leonard D. Shultz Jackson Laboratory
Friedrich Koch-Nolte
Friedrich Koch-Nolte Universität Hamburg
Friedrich Haag
Friedrich Haag Universität Hamburg
Mark A. Atkinson
Mark A. Atkinson University of Florida
John P. Sundberg
John P. Sundberg Vanderbilt University
Charles O. Elson
Charles O. Elson University of Alabama at Birmingham
Gary A. Churchill
Gary A. Churchill The Jackson Laboratory
Dale L. Greiner
Dale L. Greiner University of Massachusetts Chan Medical School
Derry C. Roopenian
Derry C. Roopenian The Jackson Laboratory

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