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Immunology

D-Index
68
Citations
17922
World Ranking
2577
National Ranking
102

Overview

Thomas W. H. Kay is affiliated with the University of Melbourne in Australia. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focused engagement in Surgery, Genetics, Endocrinology, Diabetes and Metabolism, Immunology, and Pharmacology as subfields of study.

The scientific work of Thomas W. H. Kay concentrates heavily on topics related to pancreatic function and diabetes, diabetes and associated disorders, and diabetes management and research. Additional areas of interest include immune cell function and interaction, cannabis and cannabinoid research, T-cell and B-cell immunology, and renal transplantation outcomes and treatments.

Significant recent publications by Thomas W. H. Kay include:

  • "Baricitinib and β-Cell Function in Patients with New-Onset Type 1 Diabetes" (2023), published in New England Journal of Medicine
  • "Association between primary graft function and 5-year outcomes of islet allogeneic transplantation in type 1 diabetes: a retrospective, multicentre, observational cohort study in 1210 patients from the Collaborative Islet Transplant Registry" (2023), published in The Lancet Diabetes & Endocrinology
  • "The JAK1 Selective Inhibitor ABT 317 Blocks Signaling Through Interferon-γ and Common γ Chain Cytokine Receptors to Reverse Autoimmune Diabetes in NOD Mice" (2020), published in Frontiers in Immunology
  • "Inflammation versus regulation: how interferon-gamma contributes to type 1 diabetes pathogenesis" (2023), published in Frontiers in Cell and Developmental Biology
  • "A Worldwide Survey of Activities and Practices in Clinical Islet of Langerhans Transplantation" (2022), published in Transplant International

Thomas W. H. Kay frequently publishes in the following venues:

  • Transplantation
  • Diabetes
  • Frontiers in Immunology
  • Diabetes Care
  • The Lancet Diabetes & Endocrinology

Collaborations have been established extensively with colleagues including Helen E. Thomas, Balasubramanian Krishnamurthy, Thomas Loudovaris, Gaurang Jhala, and Prerak Trivedi, with co-authorships reaching up to 24 joint publications with these researchers.

Best Publications

  • Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity.

    Philippe Bouillet;Donald Metcalf;David C. S. Huang;David M. Tarlinton

  • SOCS1 Is a Critical Inhibitor of Interferon γ Signaling and Prevents the Potentially Fatal Neonatal Actions of this Cytokine

    Warren S Alexander;Robyn Starr;Robyn Starr;Jennifer E Fenner;Clare L Scott;Clare L Scott

  • Improvement in outcomes of clinical islet transplantation: 1999-2010.

    Franca B. Barton;Michael R. Rickels;Rodolfo Alejandro;Bernhard J. Hering

  • Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

    Ken T. Coppieters;Francesco Dotta;Natalie Amirian;Peter D. Campbell

  • Tumor necrosis factor α-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling

    Gregory r Steinberg;Belinda J Michell;Bryce J W Jw van Denderen;Matthew James Watt

  • Granulocyte Macrophage Colony-Stimulating Factor A New Putative Therapeutic Target in Multiple Sclerosis

    Jonathan Luke McQualter;Rima Darwiche;Christine Ewing;Manabu Onuki

  • Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice.

    I. L. Campbell;T. W. H. Kay;L. Oxbrow;L. C. Harrison

  • Transgenic Expression of Mouse Proinsulin II Prevents Diabetes in Nonobese Diabetic Mice

    Michelle B French;Janette Allison;David S Cram;Helen E Thomas

  • Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP

    Balasubramanian Krishnamurthy;Nadine L. Dudek;Mark D. McKenzie;Anthony W. Purcell

  • The insulin A-chain epitope recognized by human T cells is posttranslationally modified.

    Stuart I. Mannering;Leonard C. Harrison;Nicholas A. Williamson;Jessica S. Morris

  • Beta cell apoptosis in diabetes

    Helen E. Thomas;Helen E. Thomas;Mark D. McKenzie;Mark D. McKenzie;Eveline Angstetra;Eveline Angstetra;Peter D. Campbell;Peter D. Campbell

  • Interleukin-1 Plus γ-Interferon-Induced Pancreatic β-Cell Dysfunction Is Mediated by β-Cell Nitric Oxide Production

    Helen E. Thomas;Rima Darwiche;John A. Corbett;Thomas W.H. Kay

  • The diagnosis of insulitis in human type 1 diabetes

    M. L. Campbell-Thompson;M. A. Atkinson;A. E. Butler;N. M. Chapman

  • Abnormal neutrophil signature in the blood and pancreas of presymptomatic and symptomatic type 1 diabetes

    Federica Vecchio;Nicola Lo Buono;Angela Stabilini;Laura Nigi

  • Suppressor of Cytokine Signaling-1 Is a Critical Regulator of Interleukin-7-Dependent CD8+ T Cell Differentiation

    Mark M.W Chong;Ann L Cornish;Rima Darwiche;Edouard G Stanley

  • IL-1 Receptor Deficiency Slows Progression to Diabetes in the NOD Mouse

    Helen E. Thomas;Windy Irawaty;Rima Darwiche;Thomas C. Brodnicki

  • IL-1β Breaks Tolerance through Expansion of CD25+ Effector T Cells

    Brendan J. O’Sullivan;Helen E. Thomas;Saparna Pai;Pere Santamaria

  • Perinatal tolerance to proinsulin is sufficient to prevent autoimmune diabetes

    Gaurang Jhala;Jonathan Chee;Prerak M Trivedi;Claudia Selck

  • Proinsulin-Specific, HLA-DQ8, and HLA-DQ8-Transdimer–Restricted CD4+ T Cells Infiltrate Islets in Type 1 Diabetes

    Vimukthi Pathiraja;Janine P. Kuehlich;Peter D. Campbell;Balasubramanian Krishnamurthy;Balasubramanian Krishnamurthy

  • International Workshop on Lessons From Animal Models for Human Type 1 Diabetes: identification of insulin but not glutamic acid decarboxylase or IA-2 as specific autoantigens of humoral autoimmunity in nonobese diabetic mice.

    Ezio Bonifacio;Mark Atkinson;George Eisenbarth;David Serreze

Frequent Co-Authors

Leonard C. Harrison
Leonard C. Harrison University of Melbourne
Andrew M. Lew
Andrew M. Lew Walter and Eliza Hall Institute of Medical Research
Pere Santamaria
Pere Santamaria University of Calgary
Andreas Strasser
Andreas Strasser Walter and Eliza Hall Institute of Medical Research
Shane T. Grey
Shane T. Grey Garvan Institute of Medical Research
Gregory R. Steinberg
Gregory R. Steinberg McMaster University
Joseph A. Trapani
Joseph A. Trapani Peter MacCallum Cancer Centre
Mark Peakman
Mark Peakman King's College London
Yifan Zhan
Yifan Zhan Walter and Eliza Hall Institute of Medical Research
Bart O. Roep
Bart O. Roep Leiden University Medical Center

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