1997 - Fellow of the American Association for the Advancement of Science (AAAS)
The scientist’s investigation covers issues in Biochemistry, Molecular biology, Metallothionein, In vitro and Cancer research. John S. Lazo combines subjects such as Bleomycin hydrolase and In vivo with his study of Biochemistry. His work deals with themes such as Cell culture, Cell growth, Chelerythrine, Protein kinase A and Sanguinarine, which intersect with Molecular biology.
His research in Metallothionein intersects with topics in Lipid peroxidation, Antioxidant, Transfection, Intracellular and Drug resistance. The concepts of his In vitro study are interwoven with issues in Pharmacokinetics and Metabolism. John S. Lazo has researched Cancer research in several fields, including Cancer, Cell cycle, Cell cycle checkpoint, Diallyl trisulfide and Melphalan.
John S. Lazo focuses on Biochemistry, Molecular biology, Cell biology, In vitro and Phosphatase. Biochemistry is represented through his Enzyme, Kinase, Dual-specificity phosphatase, Protein tyrosine phosphatase and Cdc25 research. His Molecular biology research includes elements of Cell culture, Transfection, Bleomycin hydrolase, Bleomycin and Metallothionein.
John S. Lazo interconnects Apoptosis and Cell in the investigation of issues within Cell biology. His study looks at the intersection of In vitro and topics like In vivo with Cancer research. His Phosphatase study incorporates themes from CDC25A, Small molecule, Enzyme inhibitor and Protein kinase A.
Biochemistry, Drug discovery, Computational biology, Small molecule and Cancer are his primary areas of study. His research ties Pharmacokinetics and Biochemistry together. The various areas that he examines in his Drug discovery study include Carcinogenesis, RNA interference, Immunology and Drug.
His Drug research focuses on Cancer drug discovery and how it connects with Molecular biology. His Cancer research incorporates elements of Protein kinase C, Kinase, MAPK/ERK pathway and Pharmacology. His Kinase research is multidisciplinary, relying on both Cancer research, G protein-coupled receptor and Motility.
John S. Lazo mainly investigates Biochemistry, Drug discovery, Computational biology, Small molecule and Bioinformatics. His biological study spans a wide range of topics, including Antiparasitic and In vivo. Neglected Disease and Drug resistance is closely connected to Immunology in his research, which is encompassed under the umbrella topic of Drug discovery.
His studies in Computational biology integrate themes in fields like Parasitology, Chemical genetics, Drug development, Malaria and Cell based assays. His research integrates issues of Rottlerin, Cancer stem cell, Stem cell, Carcinoma and Pharmacology in his study of Small molecule. His Transfection research integrates issues from Cancer cell and Cancer.
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Overexpression of metallothionein confers resistance to anticancer drugs.
Susan L. Kelley;Alakananda Basu;Beverly A. Teicher;Miles P. Hacker.
Classification of Antineoplastic Agents by their Selective Toxicities toward Oxygenated and Hypoxic Tumor Cells
Beverly A. Teicher;John S. Lazo;Alan C. Sartorelli.
Cancer Research (1981)
Chemical genetics of Plasmodium falciparum.
W. Armand Guiguemde;Anang A. Shelat;David Bouck;Sandra Duffy.
Low molecular weight inhibitors of Myc-Max interaction and function.
Xiaoying Yin;Christine Giap;John S Lazo;Edward V Prochownik;Edward V Prochownik.
microRNA-21 Negatively Regulates Cdc25A and Cell Cycle Progression in Colon Cancer Cells
Peng Wang;Fangdong Zou;Xiaodong Zhang;Hua Li.
Cancer Research (2009)
Metallothionein protects against the cytotoxic and DNA-damaging effects of nitric oxide
MA Schwarz;JS Lazo;JC Yalowich;WP Allen.
Proceedings of the National Academy of Sciences of the United States of America (1995)
The Liver X Receptor Ligand T0901317 Decreases Amyloid β Production in Vitro and in a Mouse Model of Alzheimer's Disease
Radosveta P. Koldamova;Iliya M. Lefterov;Matthias Staufenbiel;Darren Wolfe.
Journal of Biological Chemistry (2005)
22R-Hydroxycholesterol and 9-cis-Retinoic Acid Induce ATP-binding Cassette Transporter A1 Expression and Cholesterol Efflux in Brain Cells and Decrease Amyloid β Secretion
Radosveta P. Koldamova;Iliya M. Lefterov;Milos D. Ikonomovic;John Skoko.
Journal of Biological Chemistry (2003)
Alterations in pulmonary mRNA encoding procollagens, fibronectin and transforming growth factor-beta precede bleomycin-induced pulmonary fibrosis in mice.
D G Hoyt;J S Lazo.
Journal of Pharmacology and Experimental Therapeutics (1988)
Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages
Gabriela Molina;Andreas Vogt;Ahmet Bakan;Weixiang Dai.
Nature Chemical Biology (2009)
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