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Biology and Biochemistry

D-Index
63
Citations
13131
World Ranking
10291
National Ranking
4483

Overview

Jonathan R. Brody is affiliated with Thomas Jefferson University in the United States. The research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions to subfields such as Oncology, Molecular Biology, Cancer Research, Pulmonary and Respiratory Medicine, and Surgery.

The scientist's work focuses extensively on several main topics, including:

  • Pancreatic and Hepatic Oncology Research
  • Cancer Genomics and Diagnostics
  • RNA modifications and cancer
  • Cancer, Hypoxia, and Metabolism
  • Cancer Cells and Metastasis
  • Epigenetics and DNA Methylation
  • PARP inhibition in cancer therapy

Jonathan R. Brody has published numerous papers, with some recent examples being:

  • "Overall survival in patients with pancreatic cancer receiving matched therapies following molecular profiling: a retrospective analysis of the Know Your Tumor registry trial" (2020), published in The Lancet Oncology
  • "Understanding and targeting the disease-related RNA binding protein human antigen R (HuR)" (2020), published in Wiley Interdisciplinary Reviews - RNA
  • "Limited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors" (2022), published in Nature Cancer
  • "Targeting the RNA-Binding Protein HuR in Cancer" (2023), published in Cancer Research
  • "A Phase I/II Study of Veliparib (ABT-888) in Combination with 5-Fluorouracil and Oxaliplatin in Patients with Metastatic Pancreatic Cancer" (2020), published in Clinical Cancer Research

Frequent co-authors include:

  • Rosalie C. Sears
  • Brett C. Sheppard
  • Jennifer M. Finan
  • Charles J. Yeo
  • Grace A. McCarthy

The common venues for Jonathan R. Brody's publications are:

  • Cancer Research
  • Journal of Clinical Oncology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Biology & Therapy
  • Molecular Cancer Research

Best Publications

  • Organoid profiling identifies common responders to chemotherapy in pancreatic cancer

    Hervé Tiriac;Pascal Belleau;Dannielle D Engle;Dennis Plenker

  • Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- And tissue-specific microRNAs

    Eric Londina;Phillipe Lohera;Aristeidis G. Telonis;Kevin Quann

  • Sodium boric acid: a Tris-free, cooler conductive medium for DNA electrophoresis

    Jonathan R. Brody;Scott E. Kern

  • Dual Roles of PARP-1 Promote Cancer Growth and Progression

    Matthew J. Schiewer;Jonathan F. Goodwin;Sumin Han;J. Chad Brenner

  • Overall survival in patients with pancreatic cancer receiving matched therapies following molecular profiling: a retrospective analysis of the Know Your Tumor registry trial.

    Michael J Pishvaian;Edik M Blais;Jonathan R Brody;Emily Lyons

  • Prevalence of homologous recombination-related gene mutations across multiple cancer types

    Arielle L. Heeke;Michael J. Pishvaian;Filipa Lynce;Joanne Xiu

  • An Absence of Stromal Caveolin-1 Expression Predicts Early Tumor Recurrence and Poor Clinical Outcome in Human Breast Cancers

    Agnieszka K. Witkiewicz;Abhijit Dasgupta;Federica Sotgia;Isabelle Mercier

  • Diagnostic, prognostic, and predictive biomarkers in pancreatic cancer

    Jordan M. Winter;Charles J. Yeo;Jonathan R. Brody

  • Expression of indoleamine 2,3-dioxygenase in metastatic malignant melanoma recruits regulatory T cells to avoid immune detection and affects survival

    Jonathan R. Brody;Christina L. Costantino;Adam C. Berger;Takami Sato

  • Molecular profiling of patients with pancreatic cancer: Initial results from the know your tumor initiative

    Michael J. Pishvaian;Robert J. Bender;David Halverson;Lola Rahib

  • The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR Up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase

    Christina L. Costantino;Agnieszka K. Witkiewicz;Yuki Kuwano;Joseph A. Cozzitorto

  • In vivo Therapeutic Responses Contingent on Fanconi Anemia/BRCA2 Status of the Tumor

    Michiel S. van der Heijden;Michiel S. van der Heijden;Jonathan R. Brody;David A. Dezentje;Eike Gallmeier

  • Expression of Indoleamine 2,3-Dioxygenase in Metastatic Pancreatic Ductal Adenocarcinoma Recruits Regulatory T Cells to Avoid Immune Detection

    Agnieszka Witkiewicz;Timothy K. Williams;Joseph Cozzitorto;Brandice Durkan

  • History and principles of conductive media for standard DNA electrophoresis.

    Jonathan R. Brody;Scott E. Kern

  • Genotyping and Expression Analysis of IDO2 in Human Pancreatic Cancer: A Novel, Active Target

    Agnieszka K. Witkiewicz;Christina L. Costantino;Richard Metz;Alexander J. Muller

  • Functional defects in the fanconi anemia pathway in pancreatic cancer cells.

    Michiel S. Van der Heijden;Jonathan R. Brody;Eike Gallmeier;Steven C. Cunningham

  • Understanding and targeting the disease‐related RNA binding protein human antigen R (HuR)

    Christopher W. Schultz;Ranjan Preet;Teena Dhir;Dan A. Dixon

  • Structural implications for selective targeting of PARPs

    Jamin D. Steffen;Jonathan R. Brody;Roger S. Armen;John Matteson Pascal

  • Loss of stromal caveolin-1 expression predicts poor clinical outcome in triple negative and basal-like breast cancers

    Agnieszka K. Witkiewicz;Abhijit Dasgupta;Abhijit Dasgupta;Sara Sammons;Ozlem Er

  • Epidermal growth factor receptor and insulinlike growth factor 1 receptor expression predict poor survival in pancreatic ductal adenocarcinoma

    Matias E. Valsecchi Md;Mph Mary McDonald Md;Jonathan R. Brody;Terry Hyslop

Frequent Co-Authors

Charles J. Yeo
Charles J. Yeo Thomas Jefferson University
Agnieszka K. Witkiewicz
Agnieszka K. Witkiewicz Roswell Park Cancer Institute
Emanuel F. Petricoin
Emanuel F. Petricoin George Mason University
Scott E. Kern
Scott E. Kern Johns Hopkins University
Isidore Rigoutsos
Isidore Rigoutsos Thomas Jefferson University
Wei Jiang
Wei Jiang Wuhan University
Myriam Gorospe
Myriam Gorospe National Institutes of Health
Michael P. Lisanti
Michael P. Lisanti University of Salford
Karen E. Knudsen
Karen E. Knudsen Thomas Jefferson University
George C. Prendergast
George C. Prendergast Lankenau Institute for Medical Research

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